JP2012519211A - サーチュイン調節化合物としての8−置換キノリンおよび関連類似体 - Google Patents
サーチュイン調節化合物としての8−置換キノリンおよび関連類似体 Download PDFInfo
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- JP2012519211A JP2012519211A JP2011553053A JP2011553053A JP2012519211A JP 2012519211 A JP2012519211 A JP 2012519211A JP 2011553053 A JP2011553053 A JP 2011553053A JP 2011553053 A JP2011553053 A JP 2011553053A JP 2012519211 A JP2012519211 A JP 2012519211A
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- Prior art keywords
- alkyl
- substituted
- fluoro
- heterocycle
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **C1=C(*)C(*)=C2C(*)=NC(*)=C(*)C2N1 Chemical compound **C1=C(*)C(*)=C2C(*)=NC(*)=C(*)C2N1 0.000 description 6
- SJYKVVNRRFYDSS-UHFFFAOYSA-N CC(C)(C)OC(Nc1cccnc1OC)=O Chemical compound CC(C)(C)OC(Nc1cccnc1OC)=O SJYKVVNRRFYDSS-UHFFFAOYSA-N 0.000 description 2
- OWLBQQTUOQLZST-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(CO)c[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(CO)c[s]1)=O OWLBQQTUOQLZST-UHFFFAOYSA-N 0.000 description 2
- YNJXVWIPWJKJJD-UHFFFAOYSA-N COc1ncccc1C(N)=O Chemical compound COc1ncccc1C(N)=O YNJXVWIPWJKJJD-UHFFFAOYSA-N 0.000 description 2
- CSMRUMJMLVOJQE-UHFFFAOYSA-N CC(C)(C)OC(Nc1c(C=O)ccnc1OC)=O Chemical compound CC(C)(C)OC(Nc1c(C=O)ccnc1OC)=O CSMRUMJMLVOJQE-UHFFFAOYSA-N 0.000 description 1
- DXRRTBRVTGOHIS-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(CN2CCOCC2)c[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(CN2CCOCC2)c[s]1)=O DXRRTBRVTGOHIS-UHFFFAOYSA-N 0.000 description 1
- XHFUVBWCMLLKOZ-UHFFFAOYSA-N CCOC(c1c[s]c(N)n1)=O Chemical compound CCOC(c1c[s]c(N)n1)=O XHFUVBWCMLLKOZ-UHFFFAOYSA-N 0.000 description 1
- JZDVYFVVAIFPKK-UHFFFAOYSA-N CN(C(c(ccc1ccc2)nc1c2-c1cccc(C(F)(F)F)c1)=O)c1ccc(CN2CCCC2)cc1 Chemical compound CN(C(c(ccc1ccc2)nc1c2-c1cccc(C(F)(F)F)c1)=O)c1ccc(CN2CCCC2)cc1 JZDVYFVVAIFPKK-UHFFFAOYSA-N 0.000 description 1
- GZCMOHQWMCGDBS-UHFFFAOYSA-N COC(c(ccc1ccc2)nc1c2Br)=O Chemical compound COC(c(ccc1ccc2)nc1c2Br)=O GZCMOHQWMCGDBS-UHFFFAOYSA-N 0.000 description 1
- UVZKCTBUWCIEKV-UHFFFAOYSA-N COC(c1nc2c(B(O)O)cccc2cc1)=O Chemical compound COC(c1nc2c(B(O)O)cccc2cc1)=O UVZKCTBUWCIEKV-UHFFFAOYSA-N 0.000 description 1
- ZSGZCTUJZWMBKJ-UHFFFAOYSA-N COc(ccc1ncc2)nc1c2-c1cc(C(F)(F)F)ccc1 Chemical compound COc(ccc1ncc2)nc1c2-c1cc(C(F)(F)F)ccc1 ZSGZCTUJZWMBKJ-UHFFFAOYSA-N 0.000 description 1
- HPQMRRPAOIGXFW-UHFFFAOYSA-N COc(ccc1ncc2)nc1c2Br Chemical compound COc(ccc1ncc2)nc1c2Br HPQMRRPAOIGXFW-UHFFFAOYSA-N 0.000 description 1
- FTEZJSXSARPZHJ-UHFFFAOYSA-N COc1ncccc1C(O)=O Chemical compound COc1ncccc1C(O)=O FTEZJSXSARPZHJ-UHFFFAOYSA-N 0.000 description 1
- GSAMTLRIAXVZHZ-UHFFFAOYSA-N Nc1nc(CN2CCOCC2)c[s]1 Chemical compound Nc1nc(CN2CCOCC2)c[s]1 GSAMTLRIAXVZHZ-UHFFFAOYSA-N 0.000 description 1
- FOYYLFBZULYQLC-UHFFFAOYSA-N O=C(c(ccc1ccc2)nc1c2-c1ncc(CN2CCCC2)[s]1)Nc1ncc[s]1 Chemical compound O=C(c(ccc1ccc2)nc1c2-c1ncc(CN2CCCC2)[s]1)Nc1ncc[s]1 FOYYLFBZULYQLC-UHFFFAOYSA-N 0.000 description 1
- HRCQPWXLIMWQJR-UHFFFAOYSA-N OC(c(ccc1ccc2)nc1c2-c1ncc(CN2CCCC2)[s]1)=O Chemical compound OC(c(ccc1ccc2)nc1c2-c1ncc(CN2CCCC2)[s]1)=O HRCQPWXLIMWQJR-UHFFFAOYSA-N 0.000 description 1
- RVPUQJZGLZPNAC-UHFFFAOYSA-N Oc(ccc1ncc2)nc1c2-c1cc(C(F)(F)F)ccc1 Chemical compound Oc(ccc1ncc2)nc1c2-c1cc(C(F)(F)F)ccc1 RVPUQJZGLZPNAC-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15674909P | 2009-03-02 | 2009-03-02 | |
US61/156,749 | 2009-03-02 | ||
PCT/US2010/025963 WO2010101949A1 (en) | 2009-03-02 | 2010-03-02 | 8-substituted quinolines and related analogs as sirtuin modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2012519211A true JP2012519211A (ja) | 2012-08-23 |
Family
ID=42709991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011553053A Withdrawn JP2012519211A (ja) | 2009-03-02 | 2010-03-02 | サーチュイン調節化合物としての8−置換キノリンおよび関連類似体 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2403833A4 (ru) |
JP (1) | JP2012519211A (ru) |
KR (1) | KR20110128908A (ru) |
CN (1) | CN102414180A (ru) |
AU (1) | AU2010221417A1 (ru) |
BR (1) | BRPI1011477A2 (ru) |
CA (1) | CA2754058A1 (ru) |
EA (1) | EA201171098A1 (ru) |
IL (1) | IL214943A0 (ru) |
MX (1) | MX2011009213A (ru) |
WO (1) | WO2010101949A1 (ru) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2015086180A (ja) * | 2013-10-31 | 2015-05-07 | 日本化薬株式会社 | 1,5−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤 |
JP2016505534A (ja) * | 2012-11-20 | 2016-02-25 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 置換1,6−ナフチリジン |
JP2016536320A (ja) * | 2013-11-12 | 2016-11-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 神経変性疾患の処置用の神経新生薬としてのピリド[4,3−b]ピラジン−2−カルボキサミド |
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US8685970B2 (en) | 2008-05-01 | 2014-04-01 | GlaxoSmithKline, LLC | Quinolines and related analogs as sirtuin modulators |
WO2010003048A1 (en) | 2008-07-03 | 2010-01-07 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
WO2010037127A1 (en) | 2008-09-29 | 2010-04-01 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
CA2779303A1 (en) | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
EP2571357B1 (en) | 2010-05-21 | 2016-07-06 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
DK2686303T3 (en) | 2011-03-18 | 2016-03-29 | Bayer Ip Gmbh | N- (3-carbamoylphenyl) -1 H -pyrazole-5-carboxamide derivatives and their use for controlling animal pests |
CN102250151B (zh) * | 2011-05-17 | 2013-11-06 | 中国科学院化学研究所 | 2-芳亚胺-8-苯并咪唑喹啉过渡金属配合物及其制备方法与应用 |
SG11201400310WA (en) | 2011-08-29 | 2014-06-27 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
CA2852936A1 (en) | 2011-10-20 | 2013-04-25 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
KR20140077964A (ko) * | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
CA2865043A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
DK2970272T3 (en) * | 2013-03-14 | 2019-04-23 | Merck Patent Gmbh | glycosidase |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
WO2014195333A1 (de) | 2013-06-04 | 2014-12-11 | Bayer Pharma Aktiengesellschaft | 3-aryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung |
TWI529171B (zh) * | 2013-07-29 | 2016-04-11 | 赫孚孟拉羅股份公司 | 1,7-萘啶衍生物 |
WO2015036059A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
US20160221964A1 (en) | 2013-09-16 | 2016-08-04 | Basf Se | Fungicidal pyrimidine compounds |
US10172915B2 (en) | 2013-10-20 | 2019-01-08 | Duke University | Methods and compositions for activation of sirtuins with Annexin A1 peptides |
WO2015107133A1 (de) | 2014-01-20 | 2015-07-23 | Bayer Cropscience Ag | Chinolinderivate als insektizide und akarizide |
CA2939793A1 (en) | 2014-02-19 | 2015-08-27 | Bayer Pharma Aktiengesellschaft | 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines |
JP6580074B2 (ja) | 2014-05-23 | 2019-09-25 | アクティブ バイオテック エイビー | S100阻害薬として有用な新規化合物 |
CN106817900A (zh) * | 2014-07-17 | 2017-06-09 | 默克专利有限公司 | 新颖的萘啶和异喹啉及其作为cdk8/19抑制剂的用途 |
AU2015295405B2 (en) | 2014-08-01 | 2020-04-09 | Nuevolution A/S | Compounds active towards bromodomains |
MA40532A (fr) | 2014-08-28 | 2021-04-28 | Asceneuron Sa | Inhibiteurs de glycosidases |
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BR112017017032A2 (pt) * | 2015-02-11 | 2018-04-10 | Basilea Pharmaceutica International AG | derivados de mono e poliazanaftaleno substituídos e uso dos mesmos |
SG11201807012QA (en) | 2016-02-25 | 2018-09-27 | Asceneuron S A | Acid addition salts of piperazine derivatives |
US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
AU2017222964B2 (en) | 2016-02-25 | 2020-01-02 | Asceneuron S. A. | Glycosidase inhibitors |
EP3419971B1 (en) | 2016-02-25 | 2022-04-20 | Asceneuron SA | Glycosidase inhibitors |
WO2019037860A1 (en) | 2017-08-24 | 2019-02-28 | Asceneuron S.A. | LINEAR INHIBITORS OF GLYCOSIDASE |
US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
BR112021017049A2 (pt) * | 2019-02-28 | 2022-02-08 | Kezar Life Sciences | Derivados de tiazol como inibidores de secreção de proteínas |
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US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
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Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999029318A1 (en) * | 1997-12-11 | 1999-06-17 | Biochem Pharma Inc. | Antiviral compounds |
FR2827599A1 (fr) * | 2001-07-20 | 2003-01-24 | Neuro3D | Composes derives de quinoleine et quinoxaline,preparation et utilisations |
SE0103649D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
EP1601357A4 (en) * | 2003-03-10 | 2007-10-03 | Schering Corp | HETEROCYCLIC KINASE INHIBITORS: METHOD OF USE AND SYNTHESIS |
EP1773834A2 (en) * | 2004-08-03 | 2007-04-18 | Serenex, Inc. | 2, 8-disubstituted naphthyridine derivatives |
WO2006094237A2 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Acridine and quinoline dervatives as sirtuin modulators |
EP2250152A1 (en) * | 2008-02-28 | 2010-11-17 | Novartis AG | Quinolines as inhibitors of farnesyl pyrophosphate synthase |
US8685970B2 (en) * | 2008-05-01 | 2014-04-01 | GlaxoSmithKline, LLC | Quinolines and related analogs as sirtuin modulators |
WO2010037127A1 (en) * | 2008-09-29 | 2010-04-01 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
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2010
- 2010-03-02 CN CN2010800194505A patent/CN102414180A/zh active Pending
- 2010-03-02 AU AU2010221417A patent/AU2010221417A1/en not_active Abandoned
- 2010-03-02 KR KR1020117023017A patent/KR20110128908A/ko not_active Application Discontinuation
- 2010-03-02 BR BRPI1011477A patent/BRPI1011477A2/pt not_active Application Discontinuation
- 2010-03-02 EP EP10749227A patent/EP2403833A4/en not_active Withdrawn
- 2010-03-02 JP JP2011553053A patent/JP2012519211A/ja not_active Withdrawn
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- 2010-03-02 MX MX2011009213A patent/MX2011009213A/es not_active Application Discontinuation
- 2010-03-02 CA CA2754058A patent/CA2754058A1/en not_active Abandoned
- 2010-03-02 WO PCT/US2010/025963 patent/WO2010101949A1/en active Application Filing
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2011
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016505534A (ja) * | 2012-11-20 | 2016-02-25 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 置換1,6−ナフチリジン |
JP2015086180A (ja) * | 2013-10-31 | 2015-05-07 | 日本化薬株式会社 | 1,5−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤 |
JP2016536320A (ja) * | 2013-11-12 | 2016-11-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 神経変性疾患の処置用の神経新生薬としてのピリド[4,3−b]ピラジン−2−カルボキサミド |
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IL214943A0 (en) | 2011-11-30 |
MX2011009213A (es) | 2011-12-14 |
KR20110128908A (ko) | 2011-11-30 |
EP2403833A4 (en) | 2012-08-29 |
BRPI1011477A2 (pt) | 2016-03-22 |
WO2010101949A1 (en) | 2010-09-10 |
CN102414180A (zh) | 2012-04-11 |
EP2403833A1 (en) | 2012-01-11 |
EA201171098A1 (ru) | 2012-04-30 |
CA2754058A1 (en) | 2010-09-10 |
AU2010221417A1 (en) | 2011-09-22 |
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