SG11201807012QA - Acid addition salts of piperazine derivatives - Google Patents

Acid addition salts of piperazine derivatives

Info

Publication number
SG11201807012QA
SG11201807012QA SG11201807012QA SG11201807012QA SG11201807012QA SG 11201807012Q A SG11201807012Q A SG 11201807012QA SG 11201807012Q A SG11201807012Q A SG 11201807012QA SG 11201807012Q A SG11201807012Q A SG 11201807012QA SG 11201807012Q A SG11201807012Q A SG 11201807012QA
Authority
SG
Singapore
Prior art keywords
international
co7d
acid addition
addition salts
pct
Prior art date
Application number
SG11201807012QA
Inventor
Anna Quattropani
Santosh Kulkarni
Awadut Gajendra Giri
Dawn Toronto
David Crowe
Original Assignee
Asceneuron S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asceneuron S A filed Critical Asceneuron S A
Publication of SG11201807012QA publication Critical patent/SG11201807012QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 1111101110101110M1011100 1111111110111011# 11 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date .......,,,i WO 2017/144637 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: ZEMAN, Steven; Grilnecker Patent- and Recht- CO7D 417/12 (2006.01) A61K 31/497 (2006.01) sanwalte PartG mbB, Leopoldstr. 4, 80802 Miinchen (DE). CO7D 405/12 (2006.01) A61K 31/506 (2006.01) C07D 417/14 (2006.01) A61K 31/5377 (2006.01) (81) Designated States (unless otherwise indicated, for every C07D 405/14 (2006.01) A61P 25/00 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 513/04 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, PCT/EP2017/054278 HN, KP, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 24 February 2017 (24.02.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, TH, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 201621006638 25 February 2016 (25.02.2016) IN kind of regional protection available): ARIPO (BW, GH, (71) Applicant: ASCENEURON S. A. [CH/CH]; EPFL Innov- GM, ation Park, Batiment B, 1015 Lausanne (CH). TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: QUATTROPANI, Anna; Grand'Rue 5, 1180 DK, Rolle (CH). KULKARNI, Santosh, S.; A206, Temple LV, Trees Apartment, J P Nagar 6th Phase, Bangalore 560078 SM, (IN). GIRI, Awadut Gajendra; Flat no. 408 MB4 Surya GW, KM, ML, MR, NE, SN, TD, TG). City, Chandapura, Bangalore 560099 (IN). TORONTO, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Dawn, V.; 45, rue du bourg, 39230 Saint-Lamain (FR). Published: CROWE, David, Malcolm; Pharmaterials LTD, 5 Boulton — with international search report (Art. 21(3)) Road, Reading Berkshire RG2 ONH (GB). 1-1 IN M iv iv 1-1 IN 1-1 0 \" (54) Title: ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES (57) : The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and in particular as glycosidase inhibitors.
SG11201807012QA 2016-02-25 2017-02-24 Acid addition salts of piperazine derivatives SG11201807012QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621006638 2016-02-25
PCT/EP2017/054278 WO2017144637A1 (en) 2016-02-25 2017-02-24 Acid addition salts of piperazine derivatives

Publications (1)

Publication Number Publication Date
SG11201807012QA true SG11201807012QA (en) 2018-09-27

Family

ID=58159076

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201807012QA SG11201807012QA (en) 2016-02-25 2017-02-24 Acid addition salts of piperazine derivatives

Country Status (14)

Country Link
US (3) US10696668B2 (en)
EP (1) EP3419976B1 (en)
JP (1) JP6971999B2 (en)
KR (1) KR20180132060A (en)
CN (1) CN109071526B (en)
AU (1) AU2017222962B2 (en)
BR (1) BR112018017225A2 (en)
CA (1) CA3014572C (en)
EA (1) EA201891438A1 (en)
ES (1) ES2879351T3 (en)
MX (1) MX2018010301A (en)
SG (1) SG11201807012QA (en)
WO (1) WO2017144637A1 (en)
ZA (1) ZA201804870B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6563017B2 (en) 2014-08-28 2019-08-21 エースニューロン・ソシエテ・アノニム Glycosidase inhibitor
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
EA201891438A1 (en) * 2016-02-25 2019-01-31 Асенейрон С. А. ACID ADDITIVE SALTS DERIVATIVES OF PIPERAZINE
WO2017144633A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
CN108884078A (en) 2016-02-25 2018-11-23 阿森纽荣股份公司 Glycosidase inhibitor
AU2017378186A1 (en) 2016-12-16 2019-06-13 Janssen Pharmaceutica Nv Monocyclic OGA inhibitor compounds
AU2017400271B2 (en) * 2017-02-24 2020-09-24 Asceneuron S.A. Sulfoximine glycosidase inhibitors
US11213525B2 (en) 2017-08-24 2022-01-04 Asceneuron Sa Linear glycosidase inhibitors
EP3810586A1 (en) * 2018-06-21 2021-04-28 Janssen Pharmaceutica NV Oga inhibitor compounds
WO2020039030A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
US11795165B2 (en) 2018-08-22 2023-10-24 Asceneuron Sa Tetrahydro-benzoazepine glycosidase inhibitors
WO2021094312A1 (en) 2019-11-11 2021-05-20 Janssen Pharmaceutica Nv Pyrrolidine and bicycloheteroaryl containing oga inhibitor compounds
WO2021110656A1 (en) 2019-12-02 2021-06-10 Janssen Pharmaceutica Nv Oga inhibitor compounds
KR20220118483A (en) 2019-12-18 2022-08-25 얀센 파마슈티카 엔.브이. OGA inhibitor compounds
WO2021123291A1 (en) 2019-12-18 2021-06-24 Janssen Pharmaceutica Nv Oga inhibitor compounds
JP2023507180A (en) 2019-12-18 2023-02-21 ヤンセン ファーマシューティカ エヌ．ベー． OGA inhibitor compounds
GB202012969D0 (en) * 2020-08-19 2020-09-30 Univ Of Oxford Inhibitor compounds
AU2021455177A1 (en) * 2021-07-05 2024-01-18 Asceneuron Sa Medicaments comprising glycosidase inhibitors

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1311316A (en) 1961-04-12 1962-12-07 Science Union Et Compagnie Soc New piperazine derivatives and their preparations
NL127996C (en) 1963-11-19
US3485757A (en) 1964-11-23 1969-12-23 Atomic Energy Commission Thermoelectric composition comprising doped bismuth telluride,silicon and boron
DE1595923A1 (en) * 1965-02-20 1969-11-27 Merck Ag E 1-Aralkyl-4- (thiazolyl-2) -piperazines and processes for their preparation
GB1165283A (en) 1967-01-17 1969-09-24 Science Union & Cie New Purine Derivatives and processes for prepararing them
US4600025A (en) 1982-11-18 1986-07-15 Grigg Ronald E Smoking products comprising nicotine substitutes
WO1993021181A1 (en) 1992-04-15 1993-10-28 Merck Sharp & Dohme Limited Azacyclic compounds
IL118768A (en) 1995-07-12 2000-10-31 Akzo Nobel Nv Diphenylmethane piperidine derivatives pharmaceutical compositions containing them and a method for their preparation
TW504510B (en) 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6534496B1 (en) 1997-04-17 2003-03-18 Takeda Chemical Industries, Inc. Thermogenic composition and benzazepine thermogenics
WO1999021850A1 (en) 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
MXPA03010612A (en) * 2001-05-22 2004-04-02 Neurogen Corp Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues.
US6982259B2 (en) 2002-04-30 2006-01-03 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
EP1534703A2 (en) 2002-06-12 2005-06-01 Abbott Laboratories Antagonists of melanin concentrating hormone receptor
JP4881559B2 (en) 2002-06-27 2012-02-22 ノボ・ノルデイスク・エー／エス Arylcarbonyl derivatives as therapeutic agents
DE60330456D1 (en) 2002-07-05 2010-01-21 Targacept Inc N-ARYL DIAZASPIROCYCLIC COMPOUNDS, THEIR USE AND THE METHOD FOR THEIR PREPARATION
KR20050043935A (en) 2002-09-09 2005-05-11 얀센 파마슈티카 엔.브이. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
CN1777584A (en) 2003-04-18 2006-05-24 伊莱利利公司 (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht 1f agonists
JP4552854B2 (en) * 2003-05-21 2010-09-29 萬有製薬株式会社 2-Aminoquinoline derivative
DK1723128T3 (en) 2004-01-06 2013-02-18 Novo Nordisk As Heteroarlurines and their use as glucokinase activators
WO2005110982A2 (en) 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
HU227119B1 (en) 2004-07-29 2010-07-28 Richter Gedeon Nyrt Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them
HUP0401522A2 (en) 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
US20080287375A1 (en) 2005-03-01 2008-11-20 Simon Fraser University Selective Glycosidase Inhibitors, Methods of Making Inhibitors, and Uses Thereof
TW200724140A (en) 2005-05-27 2007-07-01 Eisai Co Ltd Hydantoin compounds
CA2614518A1 (en) 2005-07-08 2007-01-18 Novo-Nordisk A/S Dicycloalkyl urea glucokinase activators
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
JP2009532381A (en) 2006-03-31 2009-09-10 アストラゼネカ アクチボラグ Bicyclic benzimidazole compounds and use of the compounds as metabotropic glutamate receptor potentiators
US20090306126A1 (en) 2006-05-22 2009-12-10 Astrazeneca Ab Indole Derivatives
US20080051387A1 (en) 2006-06-09 2008-02-28 Yuelian Xu Tetrahydropyrido[3,4-d]pyrimidines and related analogues
WO2008012623A1 (en) 2006-07-25 2008-01-31 Pfizer Products Inc. Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor
AU2007291870B2 (en) 2006-08-31 2012-12-06 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US20100022517A1 (en) 2006-12-18 2010-01-28 Richards Lori A Ophthalmic formulation of rho kinase inhibitor compound
WO2008138842A1 (en) 2007-05-10 2008-11-20 Galapagos N.V. Imidazopyrazines and triazolopyrazine for the treatment of joint degenerative and inflammatory diseases
WO2009011904A1 (en) 2007-07-19 2009-01-22 Renovis, Inc. Compounds useful as faah modulators and uses thereof
EP2215075B1 (en) 2007-10-26 2013-12-11 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp inhibitors
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009127948A1 (en) 2008-04-17 2009-10-22 Pfizer Inc. 4- [3- (aryloxy) benzylidene] -3-methyl piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors
EP2276738A1 (en) 2008-04-17 2011-01-26 Pfizer Inc. Ether benzylidene piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
EP2301936A1 (en) 2008-06-19 2011-03-30 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diarylketoxime derivative
JP2010065024A (en) 2008-08-14 2010-03-25 Ishihara Sangyo Kaisha Ltd Pest control agent containing triazolopyrimidine derivative or salt thereof
WO2010021381A1 (en) 2008-08-22 2010-02-25 武田薬品工業株式会社 Fused heterocyclic derivative and use thereof
CA2735269C (en) 2008-08-29 2018-10-16 Saint Mary's University Use of gluconacetobacter with reduced use of nitrogen fertilizer to improve beet crop production
CN102137841B (en) 2008-09-02 2014-05-14 日产化学工业株式会社 Ortho-substituted haloalkylsulfonanilide derivative and herbicide
TW201030007A (en) 2009-02-06 2010-08-16 Gruenenthal Gmbh Substituted spiro-amides as b1r modulators
EA201171098A1 (en) 2009-03-02 2012-04-30 Сертрис Фармасьютикалз, Инк. 8-SUBSTITUTE QUINOLINES AND RELATED ANALOGUES AS SIRTUIN MODULATORS
WO2010108115A1 (en) 2009-03-20 2010-09-23 Sanford-Burnham Medical Research Institute Allosteric jnk inhibitors
US20120010186A1 (en) 2009-03-23 2012-01-12 Merck Frosst Canada Ltd. Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
JP2010270034A (en) 2009-05-20 2010-12-02 Sumitomo Chemical Co Ltd Amide compound, and use therefor in controlling plant disease
WO2010151318A1 (en) 2009-06-22 2010-12-29 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
DE102009049679A1 (en) * 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
US9120781B2 (en) 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US20130196971A1 (en) 2010-09-17 2013-08-01 Christopher Joseph Aquino Fatty acid synthase inhibitors
JP5852666B2 (en) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
US8933040B2 (en) 2010-11-08 2015-01-13 Craig A. Coburn Selective glycosidase inhibitors and uses thereof
WO2012061972A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2655388B1 (en) 2010-12-23 2016-06-08 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
GB201103526D0 (en) 2011-03-02 2011-04-13 Summit Corp Plc Selective glycosidase inhibitors and uses thereof
TW201300358A (en) 2011-03-14 2013-01-01 大正製藥股份有限公司 Nitrogen-containing condensed heterocyclic compound
DK2748171T3 (en) 2011-08-25 2016-05-09 Merck Patent Gmbh PYRANO [3,2-D] [1,3] THIAZOL AS GLYCOSIDASE INHIBITORS
WO2013066729A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
AR092031A1 (en) 2012-07-26 2015-03-18 Merck Sharp & Dohme INHIBITORS OF THE EXTERNAL RENAL MEDULAR POTASSIUM CHANNEL
EP2882733B1 (en) 2012-08-08 2017-04-26 Novartis Tiergesundheit AG Substituted azines as pesticides
WO2014032187A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
CN105143222B (en) * 2013-03-14 2018-02-02 默克专利有限公司 Glycosidase inhibitor
CN103435606A (en) 2013-08-22 2013-12-11 中国药科大学 CDK2 and CSK3beta dual inhibitor and application thereof
SI3318565T1 (en) 2013-12-05 2021-07-30 Pfizer Inc. Pyrrolo(2,3-d)pyrimidinyl, pyrrolo(2,3-b)pyrazinyl and pyrrolo(2,3-d)pyridinyl acrylamides
EP2913330A1 (en) 2014-02-27 2015-09-02 Laboratoire Biodim Condensed derivatives of imidazole useful as pharmaceuticals
PT3597649T (en) 2014-04-23 2022-01-21 Dart Neuroscience Llc Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors
JP6563017B2 (en) 2014-08-28 2019-08-21 エースニューロン・ソシエテ・アノニム Glycosidase inhibitor
MA42293A (en) 2015-07-02 2018-05-09 Janssen Sciences Ireland Uc ANTIBACTERIAL COMPOUNDS
MX2018005342A (en) 2015-11-02 2018-08-15 Janseen Pharmaceutica Nv [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-7-YL COMPOUND.
WO2017087863A1 (en) 2015-11-20 2017-05-26 Abide Therapeutics, Inc. Pyrazole compounds and methods of making and using same
WO2017087858A1 (en) 2015-11-20 2017-05-26 Abide Therapeutics, Inc. Pyrazole compounds and methods of making and using same
ES2893613T3 (en) 2015-11-25 2022-02-09 Lieber Inst Inc Dba Lieber Inst For Brain Development Tetrahydro-8H-pyrido[1,2-a]pyrazin-8-ones as COMT inhibitors for the treatment of neurodegenerative disorders
EP3389658B1 (en) 2015-12-18 2020-11-25 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
WO2017144633A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
EA201891438A1 (en) * 2016-02-25 2019-01-31 Асенейрон С. А. ACID ADDITIVE SALTS DERIVATIVES OF PIPERAZINE
CN108884078A (en) 2016-02-25 2018-11-23 阿森纽荣股份公司 Glycosidase inhibitor
CA3014376A1 (en) 2016-02-25 2017-08-31 Asceneuron S.A. Process for the separation of enantiomers of piperazine derivatives
WO2017223243A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
US11186564B2 (en) 2016-08-04 2021-11-30 Sunovion Pharmaceuticals Inc. Dual NAV1.2/5HT2a inhibitors for treating CNS disorders
AU2017378186A1 (en) 2016-12-16 2019-06-13 Janssen Pharmaceutica Nv Monocyclic OGA inhibitor compounds
CN110312716A (en) 2016-12-16 2019-10-08 詹森药业有限公司 Bicyclic OGA inhibitor compound
TWI654978B (en) 2017-01-27 2019-04-01 美商美國禮來大藥廠 5-methyl-1,2,4-oxadiazol-3-yl compounds
EP3577121A1 (en) 2017-02-06 2019-12-11 Janssen Pharmaceutica NV Oga inhibitor compounds
AU2017400271B2 (en) 2017-02-24 2020-09-24 Asceneuron S.A. Sulfoximine glycosidase inhibitors
JP2020509004A (en) 2017-02-27 2020-03-26 ヤンセン ファーマシューティカ エヌ．ベー． [1,2,4] -Triazolo [1,5-A] -pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as OGA inhibitors
TWI669302B (en) 2017-05-25 2019-08-21 美商美國禮來大藥廠 5-methyl-1,3,4-oxadiazol-2-yl compounds
US11213525B2 (en) 2017-08-24 2022-01-04 Asceneuron Sa Linear glycosidase inhibitors
WO2020039027A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Pyrrolidine glycosidase inhibitors
WO2020039030A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors

Also Published As

Publication number Publication date
US20200385375A1 (en) 2020-12-10
MX2018010301A (en) 2019-05-20
US20230120169A1 (en) 2023-04-20
JP2019506429A (en) 2019-03-07
AU2017222962B2 (en) 2021-03-25
CA3014572C (en) 2023-10-03
WO2017144637A1 (en) 2017-08-31
AU2017222962A1 (en) 2018-08-23
EA201891438A1 (en) 2019-01-31
CN109071526A (en) 2018-12-21
CN109071526B (en) 2023-02-28
KR20180132060A (en) 2018-12-11
JP6971999B2 (en) 2021-11-24
EP3419976B1 (en) 2021-04-07
US10696668B2 (en) 2020-06-30
US20190055233A1 (en) 2019-02-21
ES2879351T3 (en) 2021-11-22
BR112018017225A2 (en) 2019-01-15
EP3419976A1 (en) 2019-01-02
CA3014572A1 (en) 2017-08-31
US11591327B2 (en) 2023-02-28
ZA201804870B (en) 2023-02-22

Similar Documents

Publication Publication Date Title
SG11201807012QA (en) Acid addition salts of piperazine derivatives
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201907774VA (en) Sulfoximine glycosidase inhibitors
SG11201906891RA (en) Methods for the administration of certain vmat2 inhibitors
SG11201804098TA (en) Purinones as ubiquitin-specific protease 1 inhibitors
SG11201807784SA (en) 3-desoxy derivative and pharmaceutical compositions thereof
SG11201901445TA (en) A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
SG11201805300QA (en) Heterocyclic compounds as immunomodulators
SG11201804934PA (en) Novel Compounds
SG11201900163PA (en) Macrocycle kinase inhibitors
SG11201807005VA (en) Process for the separation of enantiomers of piperazine derivatives
SG11201804774YA (en) Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
SG11201806267QA (en) Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose
SG11201809499UA (en) Processes for preparing phosphorodiamidate morpholino oligomers
SG11201901438VA (en) Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate
SG11201809497RA (en) Processes for preparing phosphorodiamidate morpholino oligomers
SG11201810143PA (en) Exon skipping oligomers for muscular dystrophy
SG11201903230QA (en) TCRa HOMING ENDONUCLEASE VARIANTS
SG11202000333UA (en) Bicyclic ketone compounds and methods of use thereof
SG11201909807TA (en) Methods of manufacturing of niraparib
SG11201805170XA (en) Cellular glycosaminoglycan compositions and methods of making and using
SG11201811686UA (en) 18f-labeled triazole containing psma inhibitors
SG11201908091QA (en) Aqueous anti-pd-l1 antibody formulation
SG11201901477PA (en) Compound for use in the treatment of neurogenic orthostatic hypotension
SG11201408171SA (en) Fbxo3 inhibitors