SG11201907774VA - Sulfoximine glycosidase inhibitors - Google Patents

Sulfoximine glycosidase inhibitors

Info

Publication number
SG11201907774VA
SG11201907774VA SG11201907774VA SG11201907774VA SG11201907774VA SG 11201907774V A SG11201907774V A SG 11201907774VA SG 11201907774V A SG11201907774V A SG 11201907774VA SG 11201907774V A SG11201907774V A SG 11201907774VA SG 11201907774V A SG11201907774V A SG 11201907774VA
Authority
SG
Singapore
Prior art keywords
international
pct
february
publication
date
Prior art date
Application number
SG11201907774VA
Inventor
Anna Quattropani
Santosh S Kulkarni
Awadut Gajendra Giri
Original Assignee
Asceneuron S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2017/054280 external-priority patent/WO2017144639A1/en
Priority claimed from PCT/EP2017/054268 external-priority patent/WO2017144633A1/en
Application filed by Asceneuron S A filed Critical Asceneuron S A
Publication of SG11201907774VA publication Critical patent/SG11201907774VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo °H0111 m ioo Imo 111E1111°111 (10) International Publication Number WO 2018/153508 A3 (51) International Patent Classification: C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 417/12 (2006.01) C07D 401/12 (2006.01) C07D 495/04 (2006.01) (21) International Application Number: PCT/EP2017/071385 (22) International Filing Date: 24 August 2017 (24.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2017/054280 24 February 2017 (24.02.2017) EP PCT/EP2017/054268 24 February 2017 (24.02.2017) EP (71) Applicant: ASCENEURON S.A. [CH/CH]; EPFL Inno- vation Park, Batiment B, 1015 Lausanne (CH). (72) Inventors: QUATTROPANI, Anna; Grand'rue 5, 1180 Rolle (CH). KULKARNI, Santosh S.; A206, Temple Trees Apartment, J P Nagar 6th Phase, Bangalore 560078 (IN). GIRI, Awadut Gajendra; Flat no. 408 MB4 Surya City, Chandapura, Bangalore 560099 (IN). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 21 February 2019 (21.02.2019) W O 20 18/ 15 35 08 A3 (74) Agent: ZEMAN, Steven; Griinecker Patent- and Rechtsan- walte PartG mbB, Leopoldstr. 4, 80802 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: SULFOXIMINE GLYCOSIDASE INHIBITORS (I) (57) : Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
SG11201907774VA 2017-02-24 2017-08-24 Sulfoximine glycosidase inhibitors SG11201907774VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2017/054280 WO2017144639A1 (en) 2016-02-25 2017-02-24 Glycosidase inhibitors
PCT/EP2017/054268 WO2017144633A1 (en) 2016-02-25 2017-02-24 Glycosidase inhibitors
PCT/EP2017/071385 WO2018153508A2 (en) 2017-02-24 2017-08-24 Sulfoximine glycosidase inhibitors

Publications (1)

Publication Number Publication Date
SG11201907774VA true SG11201907774VA (en) 2019-09-27

Family

ID=59686981

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201907774VA SG11201907774VA (en) 2017-02-24 2017-08-24 Sulfoximine glycosidase inhibitors

Country Status (5)

Country Link
EP (2) EP3585783A2 (en)
AU (1) AU2017400271B2 (en)
MX (1) MX2019010085A (en)
SG (1) SG11201907774VA (en)
WO (2) WO2018153508A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015308437C1 (en) 2014-08-28 2020-11-05 Asceneuron Sa Glycosidase inhibitors
MX2018010192A (en) 2016-02-25 2019-01-31 Asceneuron S A Glycosidase inhibitors.
EA201891438A1 (en) 2016-02-25 2019-01-31 Асенейрон С. А. ACID ADDITIVE SALTS DERIVATIVES OF PIPERAZINE
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
MA43680A (en) 2016-02-25 2018-11-28 Asceneuron Sa GLYCOSIDASE INHIBITORS
EP3672959A1 (en) 2017-08-24 2020-07-01 Asceneuron SA Linear glycosidase inhibitors
EP3841093B1 (en) * 2018-08-22 2023-06-21 Asceneuron SA Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors
US11795165B2 (en) 2018-08-22 2023-10-24 Asceneuron Sa Tetrahydro-benzoazepine glycosidase inhibitors
US11731972B2 (en) 2018-08-22 2023-08-22 Asceneuron Sa Spiro compounds as glycosidase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127996C (en) 1963-11-19
DE1595923A1 (en) 1965-02-20 1969-11-27 Merck Ag E 1-Aralkyl-4- (thiazolyl-2) -piperazines and processes for their preparation
WO1999021850A1 (en) 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
CA2448080A1 (en) * 2001-05-22 2002-11-28 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
US7253168B2 (en) 2004-04-07 2007-08-07 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
JP5380293B2 (en) 2006-08-31 2014-01-08 サイモン・フレーザー・ユニバーシティ Selective glycosidase inhibitors and uses thereof
ES2448870T3 (en) 2007-10-26 2014-03-17 Janssen Pharmaceutica, N.V. Quinoline derivatives as PARP inhibitors
WO2014032187A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
WO2014159234A1 (en) * 2013-03-14 2014-10-02 Merck Patent Gmbh Glycosidase inhibitors
AU2015308437C1 (en) * 2014-08-28 2020-11-05 Asceneuron Sa Glycosidase inhibitors
MX2018010192A (en) * 2016-02-25 2019-01-31 Asceneuron S A Glycosidase inhibitors.
MA43680A (en) * 2016-02-25 2018-11-28 Asceneuron Sa GLYCOSIDASE INHIBITORS
EA201891438A1 (en) * 2016-02-25 2019-01-31 Асенейрон С. А. ACID ADDITIVE SALTS DERIVATIVES OF PIPERAZINE

Also Published As

Publication number Publication date
WO2018153508A2 (en) 2018-08-30
WO2018153507A1 (en) 2018-08-30
MX2019010085A (en) 2019-11-21
WO2018153508A3 (en) 2019-02-21
EP3585779A1 (en) 2020-01-01
AU2017400271A1 (en) 2019-08-22
AU2017400271B2 (en) 2020-09-24
EP3585783A2 (en) 2020-01-01

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