MX364547B - Derivados de cromanil para tratar enfermedad mitocondrial. - Google Patents

Derivados de cromanil para tratar enfermedad mitocondrial.

Info

Publication number
MX364547B
MX364547B MX2015000488A MX2015000488A MX364547B MX 364547 B MX364547 B MX 364547B MX 2015000488 A MX2015000488 A MX 2015000488A MX 2015000488 A MX2015000488 A MX 2015000488A MX 364547 B MX364547 B MX 364547B
Authority
MX
Mexico
Prior art keywords
compounds
treating
relates
nitrogen atom
derivatives
Prior art date
Application number
MX2015000488A
Other languages
English (en)
Other versions
MX2015000488A (es
Inventor
Hendrik Blaauw Richard
Gerardus George Leenders Ruben
Jan Sterk Geert
Harold Han Hermkens Pedro
Original Assignee
Khondrion Ip B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Khondrion Ip B V filed Critical Khondrion Ip B V
Priority claimed from PCT/NL2013/050528 external-priority patent/WO2014011047A1/en
Publication of MX2015000488A publication Critical patent/MX2015000488A/es
Publication of MX364547B publication Critical patent/MX364547B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se relaciona a compuestos novedosos que son útiles para la modulación de morfología mitocondrial y/o de enzimas OXPHOS y/o ROS celular. Los compuestos son derivados de TroloxTM en donde la fracción de ácido carboxílico es reemplazada por una fracción amida y en donde el átomo de nitrógeno de la fracción amida está conectada por medio de un vinculador a un átomo de nitrógeno catiónico. Los compuestos de la invención están formulados en composiciones farmacéuticas o cosméticas. La invención además se relaciona a métodos en donde los compuestos de la invención son utilizados para tratar o prevenir trastornos mitocondriales, condiciones asociadas con disfunción mitocondrial, incluyendo efectos adversos al fármaco, y/o trastornos neoplásicos. La invención también se relaciona a métodos cosméticos para tratar o retrasar el envejecimiento de la piel y aplicaciones veterinarias.
MX2015000488A 2012-07-12 2013-07-12 Derivados de cromanil para tratar enfermedad mitocondrial. MX364547B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261670644P 2012-07-12 2012-07-12
EP12176128 2012-07-12
PCT/NL2013/050528 WO2014011047A1 (en) 2012-07-12 2013-07-12 Chromanyl derivatives for treating mitochondrial disease

Publications (2)

Publication Number Publication Date
MX2015000488A MX2015000488A (es) 2015-04-08
MX364547B true MX364547B (es) 2019-04-30

Family

ID=53577992

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000488A MX364547B (es) 2012-07-12 2013-07-12 Derivados de cromanil para tratar enfermedad mitocondrial.

Country Status (6)

Country Link
US (1) US9388156B2 (es)
CY (1) CY1119384T1 (es)
HK (1) HK1209425A1 (es)
HR (1) HRP20170532T4 (es)
IN (1) IN2015MN00114A (es)
MX (1) MX364547B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102660473B1 (ko) * 2017-04-05 2024-04-24 콘드리온 아이피 비.브이. 미토콘드리아 질환의 신규 치료
MX2020005238A (es) * 2017-11-22 2020-08-24 Khondrion Ip B V Compuestos novedosos como inhibidores mpges-1.
IL274822B2 (en) * 2017-11-22 2024-03-01 Khondrion Ip B V Substances for the treatment of depression and migraine
CA3127590A1 (en) 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Mitofusin activators and methods of use thereof
JP2022523702A (ja) 2019-01-28 2022-04-26 ミトコンドリア エモーション， インク． トランス－４－ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR019190A1 (es) 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
AU2001262200A1 (en) 2000-04-25 2001-11-07 Schering Aktiengesellschaft Benzoxazine derivatives and benzothiazine derivatives having nos-inhibitory and antioxidant properties
JP2002047272A (ja) 2000-07-26 2002-02-12 Dai Ichi Seiyaku Co Ltd ポリアミンアミド誘導体
EP3018122B1 (en) 2007-11-06 2018-10-10 BioElectron Technology Corporation 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases

Also Published As

Publication number Publication date
CY1119384T1 (el) 2018-02-14
HK1209425A1 (zh) 2016-04-01
HRP20170532T4 (hr) 2019-12-27
IN2015MN00114A (es) 2015-10-16
HRP20170532T1 (hr) 2017-06-16
US9388156B2 (en) 2016-07-12
US20150166501A1 (en) 2015-06-18
MX2015000488A (es) 2015-04-08

Similar Documents

Publication Publication Date Title
MX368504B (es) Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos.
PH12020550503A1 (en) Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors
EA201400161A1 (ru) Замещенные гетероароматические пиразолсодержащие карбоксамидные и мочевинные производные в качестве лигандов ваниллоидных рецепторов
MX2015003653A (es) Derivados de amida del acido benzoimidazol-carboxilico como moduladores del receptor apj.
MX343706B (es) Derivados heterocíclicos novedosos.
EA201490864A1 (ru) Производные (4-фенилимидазол-2-ил)этиламина в качестве модуляторов натриевых каналов
PH12014501967B1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
BR112017009583A2 (pt) 2-amino-6-(difluorometil)-5,5-difluoro-6-fenil-3,4,5,6-tetraidropiridinas como inibidoras da bace1
PH12017501095A1 (en) Piperidine derivatives as hdac1/2 inhibitors
NZ719169A (en) Heteroaryl butanoic acid derivatives as lta4h inhibitors
CY1119384T1 (el) Παραγωγα χρωμανυλιου για αντιμετωπιση μιτοχονδριακης νοσου
MX2020005879A (es) Composiciones administrables vía intravenosa que comprenden ácidos de grado farmacéutico y reguladores del ph, y el uso de las mismas para tratar enfermedades de disfunción mitocondrial, enfermedades metabólicas y de disfunción del modelado de huesos y tejidos.
PH12016501977A1 (en) 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
CY1121063T1 (el) Αναστολεις της συνθασης της αλδοστερονης
CY1121650T1 (el) Αναστολεις συνθασης αλδοστερονης
PH12017500351A1 (en) N-(2-(cyclic amine)ethyl)benzamide derivatives as p2x7 inhibitors
MX362059B (es) Derivados de carbamato/urea.
MX364400B (es) Compuestos de tetraciclina.
PH12014501943A1 (en) Novel compounds for the treatment of dyslipidemia and related diseases
MX2013003202A (es) Inhibidores de oxadiazol de la produccion de leucotrienos.
PL420169A1 (pl) N-Guanylowe pochodne 9-amino-5,11-dimetylo-5H-indolo[2,3-b]chinoliny, sposób ich otrzymywania i zawierające je środki farmaceutyczne
TN2013000327A1 (en) Novel heterocyclic derivatives
CA2905957C (en) Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders
MX2015012393A (es) Derivados oxindol con un sustituyente oxetano y uso de los mismos para tratar enfermedades relacionadas con la vasopresina.

Legal Events

Date Code Title Description
FG Grant or registration