MX364547B - Derivados de cromanil para tratar enfermedad mitocondrial. - Google Patents
Derivados de cromanil para tratar enfermedad mitocondrial.Info
- Publication number
- MX364547B MX364547B MX2015000488A MX2015000488A MX364547B MX 364547 B MX364547 B MX 364547B MX 2015000488 A MX2015000488 A MX 2015000488A MX 2015000488 A MX2015000488 A MX 2015000488A MX 364547 B MX364547 B MX 364547B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- treating
- relates
- nitrogen atom
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención se relaciona a compuestos novedosos que son útiles para la modulación de morfología mitocondrial y/o de enzimas OXPHOS y/o ROS celular. Los compuestos son derivados de TroloxTM en donde la fracción de ácido carboxílico es reemplazada por una fracción amida y en donde el átomo de nitrógeno de la fracción amida está conectada por medio de un vinculador a un átomo de nitrógeno catiónico. Los compuestos de la invención están formulados en composiciones farmacéuticas o cosméticas. La invención además se relaciona a métodos en donde los compuestos de la invención son utilizados para tratar o prevenir trastornos mitocondriales, condiciones asociadas con disfunción mitocondrial, incluyendo efectos adversos al fármaco, y/o trastornos neoplásicos. La invención también se relaciona a métodos cosméticos para tratar o retrasar el envejecimiento de la piel y aplicaciones veterinarias.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261670644P | 2012-07-12 | 2012-07-12 | |
EP12176128 | 2012-07-12 | ||
PCT/NL2013/050528 WO2014011047A1 (en) | 2012-07-12 | 2013-07-12 | Chromanyl derivatives for treating mitochondrial disease |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015000488A MX2015000488A (es) | 2015-04-08 |
MX364547B true MX364547B (es) | 2019-04-30 |
Family
ID=53577992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015000488A MX364547B (es) | 2012-07-12 | 2013-07-12 | Derivados de cromanil para tratar enfermedad mitocondrial. |
Country Status (6)
Country | Link |
---|---|
US (1) | US9388156B2 (es) |
CY (1) | CY1119384T1 (es) |
HK (1) | HK1209425A1 (es) |
HR (1) | HRP20170532T4 (es) |
IN (1) | IN2015MN00114A (es) |
MX (1) | MX364547B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4241842A3 (en) * | 2017-04-05 | 2023-11-08 | Khondrion Ip B.V. | Novel treatment of mitochondrial diseases |
AU2018371153B2 (en) * | 2017-11-22 | 2023-07-13 | Khondrion Ip B.V. | Compounds as mPGES-1 inhibitors |
CN111372582A (zh) * | 2017-11-22 | 2020-07-03 | 康尊知识产权公司 | 用于治疗抑郁症和偏头痛的新化合物 |
JP2022523702A (ja) | 2019-01-28 | 2022-04-26 | ミトコンドリア エモーション, インク. | トランス-4-ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法 |
JP7473565B2 (ja) | 2019-01-28 | 2024-04-23 | ミトコンドリア エモーション, インク. | マイトフュージン活性化物質及びその使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR019190A1 (es) | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
AU2001262200A1 (en) | 2000-04-25 | 2001-11-07 | Schering Aktiengesellschaft | Benzoxazine derivatives and benzothiazine derivatives having nos-inhibitory and antioxidant properties |
JP2002047272A (ja) | 2000-07-26 | 2002-02-12 | Dai Ichi Seiyaku Co Ltd | ポリアミンアミド誘導体 |
CA2704473C (en) | 2007-11-06 | 2016-10-04 | Edison Pharmaceuticals, Inc. | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
-
2013
- 2013-07-12 US US14/414,055 patent/US9388156B2/en active Active
- 2013-07-12 IN IN114MUN2015 patent/IN2015MN00114A/en unknown
- 2013-07-12 MX MX2015000488A patent/MX364547B/es active IP Right Grant
-
2015
- 2015-10-16 HK HK15110180.2A patent/HK1209425A1/zh active IP Right Maintenance
-
2017
- 2017-04-03 HR HRP20170532TT patent/HRP20170532T4/hr unknown
- 2017-04-07 CY CY20171100415T patent/CY1119384T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20170532T1 (hr) | 2017-06-16 |
IN2015MN00114A (es) | 2015-10-16 |
CY1119384T1 (el) | 2018-02-14 |
HK1209425A1 (zh) | 2016-04-01 |
US20150166501A1 (en) | 2015-06-18 |
MX2015000488A (es) | 2015-04-08 |
US9388156B2 (en) | 2016-07-12 |
HRP20170532T4 (hr) | 2019-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |