MX338572B - Derivados de 4-(p-quinonil)-2-hidroxibutanamida para tratamiento de enfermedades mitocondriales. - Google Patents

Derivados de 4-(p-quinonil)-2-hidroxibutanamida para tratamiento de enfermedades mitocondriales.

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Publication number
MX338572B
MX338572B MX2013012276A MX2013012276A MX338572B MX 338572 B MX338572 B MX 338572B MX 2013012276 A MX2013012276 A MX 2013012276A MX 2013012276 A MX2013012276 A MX 2013012276A MX 338572 B MX338572 B MX 338572B
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MX
Mexico
Prior art keywords
methods
disclosed
treatment
compounds useful
mitochondrial diseases
Prior art date
Application number
MX2013012276A
Other languages
English (en)
Inventor
Orion D Jankowski
Kieron E Wesson
Paul Mollard
William D Shrader
Original Assignee
Edison Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Edison Pharmaceuticals Inc filed Critical Edison Pharmaceuticals Inc
Publication of MX338572B publication Critical patent/MX338572B/es

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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Se describen métodos de tratar o suprimir enfermedades mitocondriales, tales como ataxia de Friedreich (DRDA), Neuropatía Óptica Hereditaria de Leber (LHON), miopatía mitocondrial, encefalopatía, lactacidosis, y derrames cerebrales (MELAS) y Síndrome de Kearns-Sayre (KSS), así como compuestos útiles en métodos de la invención, tales como deriados de 4-(p-quinolil)-2-hidroxibutanamida. Tmbén se desriben métodos y compuestos útiles en tratar otros trastornos tales como Esclerosis de Lateral de Amiotrófica (ALS), enfermedad de Huntington y enfermedad de Parkinson, y trastornos pervasivos del desarrollo tales como autismo. Tambén se describen biomaracadores de energía útiles en la valoración del estado metabolico de un sujeto y la eficacia de tratamiento. Tambén se describen métodos de modular, normalizar o mejorar los biomaracadores de energía, así como compuestos útiles para tales métodos.
MX2013012276A 2007-11-06 2010-04-27 Derivados de 4-(p-quinonil)-2-hidroxibutanamida para tratamiento de enfermedades mitocondriales. MX338572B (es)

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