CU20080027A7 - Bencimidazoles sustituidos como inhibidores de cinasa - Google Patents

Bencimidazoles sustituidos como inhibidores de cinasa

Info

Publication number
CU20080027A7
CU20080027A7 CU20080027A CU20080027A CU20080027A7 CU 20080027 A7 CU20080027 A7 CU 20080027A7 CU 20080027 A CU20080027 A CU 20080027A CU 20080027 A CU20080027 A CU 20080027A CU 20080027 A7 CU20080027 A7 CU 20080027A7
Authority
CU
Cuba
Prior art keywords
compositions
kinase
bencimidazols
replaced
compounds
Prior art date
Application number
CU20080027A
Other languages
English (en)
Other versions
CU23784B7 (es
Inventor
Sharadha Subramanian
Darrin Stuart
Cynthia Shafer
Paul A Renhowe
Savithri Ramurthy
Daniel J Poon
Teresa E Pick
Christopher Mcbride
Barry Haskell Levine
Jeffrey H Dove
Payman Amiri
Mina E Aikawa
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20080027A7 publication Critical patent/CU20080027A7/es
Publication of CU23784B7 publication Critical patent/CU23784B7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan nuevos compuestos de bencimidazol sustituidos de la fórmula (I), composiciones, y métodos para la inhibición de la actividad de cinasa asociada con tumorigénesis en un sujeto humano o animal. En ciertas modalidades, los compuestos y las composiciones son efectivos para inhibir la actividad de cuando menos una cinasa de serina/treonina o una cinasa de tirosina receptora. Los nuevos compuestos y composiciones se pueden utilizar solos o bien en combinación con cuando menos un agente adicional para el tratamiento de un trastorno mediado por cinasa de serina/treonina o por cinasa de tirosina receptora, tal como cáncer.
CU20080027A 2005-08-30 2008-02-25 Bencimidazoles sustituidos como inhibidores de cinasa CU23784B7 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71253905P 2005-08-30 2005-08-30
US71310805P 2005-08-30 2005-08-30
US73159105P 2005-10-27 2005-10-27
US77468406P 2006-02-17 2006-02-17

Publications (2)

Publication Number Publication Date
CU20080027A7 true CU20080027A7 (es) 2010-12-08
CU23784B7 CU23784B7 (es) 2012-02-15

Family

ID=37434025

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20080027A CU23784B7 (es) 2005-08-30 2008-02-25 Bencimidazoles sustituidos como inhibidores de cinasa

Country Status (37)

Country Link
US (6) US20070049622A1 (es)
EP (2) EP1924577B1 (es)
JP (4) JP5210866B2 (es)
KR (2) KR20080039965A (es)
AR (2) AR057109A1 (es)
AT (2) ATE526325T1 (es)
AU (2) AU2006287688B2 (es)
BR (2) BRPI0615314A2 (es)
CA (2) CA2620472C (es)
CR (1) CR9716A (es)
CU (1) CU23784B7 (es)
CY (2) CY1111871T1 (es)
DE (1) DE602006021036D1 (es)
DK (2) DK1924577T3 (es)
EA (1) EA014230B1 (es)
EC (2) ECSP088210A (es)
ES (1) ES2374451T3 (es)
GE (1) GEP20105004B (es)
GT (1) GT200600394A (es)
HK (2) HK1117519A1 (es)
HN (1) HN2008000317A (es)
HR (2) HRP20110312T1 (es)
IL (2) IL189080A (es)
MA (2) MA29772B1 (es)
MY (2) MY163886A (es)
NI (1) NI200800060A (es)
NO (1) NO20081476L (es)
NZ (2) NZ565450A (es)
PE (2) PE20070427A1 (es)
PL (2) PL1926722T3 (es)
PT (2) PT1924577E (es)
RS (1) RS52099B (es)
SI (2) SI1924577T1 (es)
SM (1) SMAP200800022A (es)
TN (2) TNSN08088A1 (es)
TW (2) TW200804345A (es)
WO (2) WO2007030377A1 (es)

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