SI2782557T1 - Farmacevtske formulacije - Google Patents

Farmacevtske formulacije

Info

Publication number
SI2782557T1
SI2782557T1 SI201231455T SI201231455T SI2782557T1 SI 2782557 T1 SI2782557 T1 SI 2782557T1 SI 201231455 T SI201231455 T SI 201231455T SI 201231455 T SI201231455 T SI 201231455T SI 2782557 T1 SI2782557 T1 SI 2782557T1
Authority
SI
Slovenia
Prior art keywords
pharmaceutical formulations
formulations
pharmaceutical
Prior art date
Application number
SI201231455T
Other languages
English (en)
Inventor
Daya Verma
Yogita Krishnamachari
Xiaohong Shen
Hanchen Lee
Ping Li
Rajinder Singh
Laychoo Tan
Original Assignee
Array Biopharma, Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47501412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2782557(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma, Inc., filed Critical Array Biopharma, Inc.,
Publication of SI2782557T1 publication Critical patent/SI2782557T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/282Organic compounds, e.g. fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201231455T 2011-11-23 2012-11-21 Farmacevtske formulacije SI2782557T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563229P 2011-11-23 2011-11-23
PCT/US2012/066185 WO2013078264A1 (en) 2011-11-23 2012-11-21 Pharmaceutical formulations
EP12809882.9A EP2782557B1 (en) 2011-11-23 2012-11-21 Pharmaceutical formulations

Publications (1)

Publication Number Publication Date
SI2782557T1 true SI2782557T1 (sl) 2019-02-28

Family

ID=47501412

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231455T SI2782557T1 (sl) 2011-11-23 2012-11-21 Farmacevtske formulacije

Country Status (38)

Country Link
US (4) US9387208B2 (sl)
EP (2) EP2782557B1 (sl)
JP (2) JP6216325B2 (sl)
KR (1) KR102091295B1 (sl)
CN (2) CN105708819B (sl)
AR (1) AR088936A1 (sl)
AU (1) AU2012340759C1 (sl)
BR (1) BR112014011981B8 (sl)
CA (1) CA2856406C (sl)
CL (1) CL2014001337A1 (sl)
CO (1) CO6940426A2 (sl)
CY (1) CY1121421T1 (sl)
DK (1) DK2782557T3 (sl)
EA (1) EA025389B1 (sl)
EC (1) ECSP23034537A (sl)
ES (1) ES2695099T3 (sl)
GT (1) GT201400100A (sl)
HK (1) HK1197024A1 (sl)
HR (1) HRP20181896T1 (sl)
HU (1) HUE040370T2 (sl)
IL (1) IL232305B (sl)
JO (1) JO3493B1 (sl)
LT (1) LT2782557T (sl)
MA (1) MA35716B1 (sl)
MX (1) MX353446B (sl)
MY (1) MY172729A (sl)
PE (1) PE20141994A1 (sl)
PH (1) PH12014501157A1 (sl)
PL (1) PL2782557T3 (sl)
PT (1) PT2782557T (sl)
RS (1) RS58048B1 (sl)
SG (1) SG11201401260QA (sl)
SI (1) SI2782557T1 (sl)
TN (1) TN2014000145A1 (sl)
TW (1) TWI649098B (sl)
UA (1) UA115039C2 (sl)
WO (1) WO2013078264A1 (sl)
ZA (1) ZA201402418B (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
CN103917236A (zh) 2011-11-11 2014-07-09 诺华股份有限公司 治疗增生性疾病的方法
LT2782557T (lt) 2011-11-23 2018-12-27 Array Biopharma, Inc. Farmacinės kompozicijos
LT3302565T (lt) 2015-06-04 2019-12-27 Pfizer Inc. Kietos palbociklibo dozavimo formos
RU2615986C1 (ru) * 2016-02-25 2017-04-12 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") Замещенные метил (2-{ 4-[3-(3-метансульфониламино-2-фтор-5-хлор-фенил)-1Н-пиразол-4-ил]пиримидин-2-иламино} -этил)карбаматы, способ их получения и применения
US10449195B2 (en) 2016-03-29 2019-10-22 Shenzhen Pharmacin Co., Ltd. Pharmaceutical formulation of palbociclib and a preparation method thereof
HUE060653T2 (hu) 2016-06-03 2023-04-28 Array Biopharma Inc Gyógyászati kombinációk
CN106000220A (zh) * 2016-06-30 2016-10-12 东华大学 一种含化学试剂的有机溶剂崩解片的制备方法与应用
CN114306245A (zh) 2020-09-29 2022-04-12 深圳市药欣生物科技有限公司 无定形固体分散体的药物组合物及其制备方法
AU2021358394A1 (en) 2020-10-05 2023-04-13 Pierre Fabre Medicament Combination of encorafenib and binimetinib as adjuvant treatment for resected stage II melanoma
CN114557977A (zh) * 2022-02-16 2022-05-31 北京康立生医药技术开发有限公司 一种治疗肠癌的药物的制备方法、制剂及纯度分析方法
WO2023239337A1 (en) * 2022-06-08 2023-12-14 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A pharmaceutical composition comprising palbociclib

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5475888A (en) 1977-11-29 1979-06-18 Jiyasuko Kk Surgical laser
US6358932B1 (en) 1994-05-31 2002-03-19 Isis Pharmaceticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US6391636B1 (en) 1994-05-31 2002-05-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US6037136A (en) 1994-10-24 2000-03-14 Cold Spring Harbor Laboratory Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
CA2231050A1 (en) * 1995-09-07 1997-03-13 Biovail International Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
US5717100A (en) 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
AR012634A1 (es) 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
BR9809147A (pt) 1997-05-22 2000-08-01 Searle & Co Composto pirazol substituìdo, composição farmacêutica, processos para tratar um distúrbio mediado por tnf, um distúrbio mediado por quinase p38, inflamação e artrite, e, para preparar pirazóis
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6204467B1 (en) 1998-03-24 2001-03-20 Ford Global Technologies, Inc. Method and apparatus for resistive welding
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US6316435B2 (en) 1999-02-24 2001-11-13 Supergen, Inc. Combination therapy for lymphoproliferative diseases
WO2001047492A1 (en) * 1999-12-23 2001-07-05 F H Faulding & Co Limited Improved pharmaceutical compositions for poorly soluble drugs
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
ATE374753T1 (de) 2001-12-21 2007-10-15 Vernalis Cambridge Ltd 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
AU2002350719A1 (en) * 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
CA2551948A1 (en) 2004-01-09 2005-07-28 Novartis Ag Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives as igf-ir inhibitors
CN1960988B (zh) 2004-06-10 2012-01-25 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
CA2618377A1 (en) 2005-08-12 2007-02-22 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate hsp90 activity
CA2619035A1 (en) 2005-08-22 2007-03-01 Novartis Ag Pharmaceutical compositions
EP1917258A2 (en) 2005-08-26 2008-05-07 SmithKline Beecham Corporation Pyrimidinyl-pyrazole inhibitors of aurora kinases
TW200804345A (en) 2005-08-30 2008-01-16 Novartis Ag Substituted benzimidazoles and methods of preparation
JP2009530261A (ja) 2006-03-16 2009-08-27 ファイザー・プロダクツ・インク ピラゾール化合物
EP2013218A2 (en) 2006-04-17 2009-01-14 Arqule, Inc. Raf inhibitors and their uses
AU2007305016B2 (en) 2006-10-02 2011-11-03 Novartis Ag Compounds and compositions as protein kinase inhibitors
KR20090063240A (ko) 2006-10-06 2009-06-17 아이알엠 엘엘씨 단백질 키나제 억제제 및 그의 사용 방법
US20090022789A1 (en) * 2007-07-18 2009-01-22 Supernus Pharmaceuticals, Inc. Enhanced formulations of lamotrigine
WO2009016460A2 (en) 2007-08-01 2009-02-05 Pfizer Inc. Pyrazole compounds and their use as raf inhibitors
RU2010119929A (ru) * 2007-10-19 2011-11-27 Эбботт Гмбх Унд Ко.Кг (De) Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины
EP2220083B1 (en) 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2274300A2 (en) 2008-03-21 2011-01-19 Novartis AG Novel heterocyclic compounds and uses therof
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
PL2324008T3 (pl) 2008-07-24 2012-09-28 Nerviano Medical Sciences Srl 3,4-diarylopirazole jako inhibitory kinazy białkowej
EP2326622A1 (en) 2008-07-28 2011-06-01 Gilead Sciences, Inc. Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
UY32146A (es) 2008-09-29 2010-04-30 Boehringer Ingelheim Int Derivados de las 5-[4-(1,5-dimetil-1h-pirazol-4-il)-1,2,3-triazol-1-il]-6-metil-nicotinamidas n-(sustituidas) y de las n-{5-[4-(1,5-dimetil-1h-pirazol-4-il)-1,2,3-triazol-1-il]-6-metil-piridin-3-il}-benzamidas sustituidas y composiciones conteniéndolos
HUE030800T2 (en) * 2008-10-07 2017-05-29 Astrazeneca Uk Ltd Pharmaceutical Form No. 514
WO2010056662A1 (en) 2008-11-11 2010-05-20 University Of Washington Activated wnt-beta-catenin signaling in melanoma
JP5490137B2 (ja) 2008-12-19 2014-05-14 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ プロテインキナーゼ阻害薬としての二環式ピラゾール
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
WO2010100127A1 (en) 2009-03-04 2010-09-10 Novartis Ag Disubstituted imidazole derivatives as modulators of raf kinase
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
WO2010145998A1 (en) 2009-06-15 2010-12-23 Nerviano Medical Sciences S.R.L. Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
KR101256018B1 (ko) 2009-08-20 2013-04-18 한국과학기술연구원 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
US8242260B2 (en) 2009-08-28 2012-08-14 Novartis Ag Compounds and compositions as protein kinase inhibitors
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
WO2011092088A1 (en) 2010-01-27 2011-08-04 Nerviano Medical Sciences S.R.L. Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors
EP2560966B1 (en) 2010-03-30 2021-01-06 Verseon International Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
US9114137B2 (en) 2010-08-03 2015-08-25 Nerviano Medical Sciences S.R.L. Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents
JP5999724B2 (ja) 2011-03-21 2016-09-28 ヴァルキュリア アクチアボラグValcuria AB Hdac阻害剤及びステロイドを含む医薬組成物及びその使用
KR20140056212A (ko) 2011-06-14 2014-05-09 노파르티스 아게 골수성증식 신생물과 같은 암 치료에서의 파노비노스타트와 룩소리티닙의 조합물
LT2782557T (lt) 2011-11-23 2018-12-27 Array Biopharma, Inc. Farmacinės kompozicijos
BR112015010477A2 (pt) 2012-11-08 2017-07-11 Novartis Ag combinação farmacêutica que compreende um inibidor b-raf e um inibidor de histona desacetilase e o uso dos mesmos no tratamento de doenças proliferativas

Also Published As

Publication number Publication date
MX2014006278A (es) 2014-07-09
MY172729A (en) 2019-12-11
PT2782557T (pt) 2018-11-26
AU2012340759A1 (en) 2014-05-29
CL2014001337A1 (es) 2014-10-24
BR112014011981B8 (pt) 2022-07-19
US9387208B2 (en) 2016-07-12
US10258622B2 (en) 2019-04-16
UA115039C2 (uk) 2017-09-11
EP3449911A1 (en) 2019-03-06
HUE040370T2 (hu) 2019-03-28
AU2012340759C1 (en) 2019-11-28
RS58048B1 (sr) 2019-02-28
CO6940426A2 (es) 2014-05-09
SG11201401260QA (en) 2014-07-30
TW201328722A (zh) 2013-07-16
KR20140095500A (ko) 2014-08-01
GT201400100A (es) 2017-09-28
BR112014011981A8 (pt) 2018-07-31
EP2782557A1 (en) 2014-10-01
US20170202837A1 (en) 2017-07-20
PH12014501157B1 (en) 2014-08-11
CN105708819A (zh) 2016-06-29
ZA201402418B (en) 2015-03-25
HK1197024A1 (en) 2015-01-02
HRP20181896T1 (hr) 2019-02-22
JP2015501808A (ja) 2015-01-19
ECSP23034537A (es) 2023-08-31
MX353446B (es) 2018-01-12
BR112014011981A2 (pt) 2017-05-30
CN103945831A (zh) 2014-07-23
CA2856406C (en) 2020-06-23
DK2782557T3 (en) 2018-12-10
TWI649098B (zh) 2019-02-01
JO3493B1 (ar) 2020-07-05
PL2782557T3 (pl) 2019-03-29
CY1121421T1 (el) 2020-05-29
TN2014000145A1 (en) 2015-09-30
US20160279129A1 (en) 2016-09-29
EP2782557B1 (en) 2018-09-12
AU2012340759B2 (en) 2016-04-28
CN105708819B (zh) 2020-12-29
AR088936A1 (es) 2014-07-16
PH12014501157A1 (en) 2014-08-11
EA025389B1 (ru) 2016-12-30
US20140309250A1 (en) 2014-10-16
US9763941B2 (en) 2017-09-19
NZ623628A (en) 2016-05-27
MA35716B1 (fr) 2014-12-01
JP6216325B2 (ja) 2017-10-18
CA2856406A1 (en) 2013-05-30
LT2782557T (lt) 2018-12-27
JP2018035171A (ja) 2018-03-08
US20190054086A1 (en) 2019-02-21
IL232305B (en) 2019-06-30
BR112014011981B1 (pt) 2020-11-17
US10561654B2 (en) 2020-02-18
EA201491007A1 (ru) 2014-08-29
ES2695099T3 (es) 2019-01-02
WO2013078264A1 (en) 2013-05-30
PE20141994A1 (es) 2014-12-24
KR102091295B1 (ko) 2020-03-19
IL232305A0 (en) 2014-06-30

Similar Documents

Publication Publication Date Title
HRP20181896T1 (hr) Farmaceutske formulacije
GB201113662D0 (en) Pharmaceutical compositions
ZA201308208B (en) Pharmaceutical compositions
HK1203812A1 (en) Novel pharmaceutical formulations
HK1199824A1 (en) Pharmaceutical compositions
SG10201604667YA (en) Pharmaceutical preparation
GB201105298D0 (en) Pharmaceutical preparation
EP2731610A4 (en) PHARMACEUTICAL COMBINATION
GB201118181D0 (en) Pharmaceutical compositions
PL2691119T3 (pl) Preparat farmaceutyczny
GB201110278D0 (en) Formulations
HK1209339A1 (en) Pharmaceutical formulations
EP2714715A4 (en) PHARMACEUTICAL COMPOSITIONS
GB201111577D0 (en) Pharmaceutical formulations
ZA201309537B (en) Pharmaceutical composition comprising fexofedine
GB201211403D0 (en) Pharmaceutical formulations
GB201211406D0 (en) Pharmaceutical formulations
GB201119796D0 (en) Pharmaceutical comopounds
GB201012046D0 (en) Pharmaceutical formulations
GB201012047D0 (en) Pharmaceutical formulations
GB201111578D0 (en) Pharmeutical formulations
GB201111013D0 (en) Formulations
GB201107627D0 (en) Formulations
GB201107626D0 (en) Formulations
GB201105410D0 (en) Formulations