PE20080130A1 - Benzoimidazol-2-il pirimidinas y pirazinas como moduladores del receptor h4 de histamina - Google Patents

Benzoimidazol-2-il pirimidinas y pirazinas como moduladores del receptor h4 de histamina

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Publication number
PE20080130A1
PE20080130A1 PE2007000389A PE2007000389A PE20080130A1 PE 20080130 A1 PE20080130 A1 PE 20080130A1 PE 2007000389 A PE2007000389 A PE 2007000389A PE 2007000389 A PE2007000389 A PE 2007000389A PE 20080130 A1 PE20080130 A1 PE 20080130A1
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PE
Peru
Prior art keywords
alkyl
methyl
receptor
pirazines
benzoimidazole
Prior art date
Application number
PE2007000389A
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English (en)
Inventor
James P Edwards
David E Kindrachuk
Original Assignee
Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20080130A1 publication Critical patent/PE20080130A1/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1A R4 SON CADA UNO H, ALQUILO C1-C4, ALQUENILO C2-C4, ENTRE OTROS; X1 y X2 SON N y C-Rc; Rc ES H, METILO, ETILO, CF3, ENTRE OTROS; n ES 1-2; Z ES N, CH, C(ALQUILO C1-C4); R6 ES H, ALQUILO C1-C6, CICLOALQUILO MONOCICLICO; R8 ES H, ALQUILO C1-C4; R9 y R10 SON H, ALQUILO C1-C4; R11 ES H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: [5-(5-FLUORO-4-METIL-1H-BENZOIMIDAZOL-2-IL)-4-METIL-PIRIMIDIN-2-IL]-[3-(1-METIL-PIPERIDIN-4-IL)-PROPIL]-AMINA; [5-(4,6-DIMETIL-1H-BENZOIMIDAZOL-2-IL)-4-METIL-PIRIMIDIN-2-IL]-[3-(1-METIL-PIPERIDIN-4-IL)-PROPIL]-AMINA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS ACTUAN A NIVEL DEL RECEPTOR H4 Y SON UTILES EN EL TRATAMIENTO DE ALERGIAS, ASMA, ENFERMEDADES AUTOINMUNES Y PRURITO
PE2007000389A 2006-03-31 2007-03-30 Benzoimidazol-2-il pirimidinas y pirazinas como moduladores del receptor h4 de histamina PE20080130A1 (es)

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US78819006P 2006-03-31 2006-03-31

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PE20080130A1 true PE20080130A1 (es) 2008-02-25

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US (6) US7507737B2 (es)
EP (1) EP2007752B1 (es)
JP (1) JP5066175B2 (es)
KR (1) KR101054325B1 (es)
CN (1) CN101460483B (es)
AR (1) AR059380A1 (es)
AT (1) ATE478067T1 (es)
AU (1) AU2007235576B2 (es)
BR (1) BRPI0710083A2 (es)
CA (1) CA2648036C (es)
CO (1) CO6160328A2 (es)
CR (1) CR10413A (es)
CY (1) CY1111169T1 (es)
DE (1) DE602007008545D1 (es)
DK (1) DK2007752T3 (es)
EA (1) EA016264B1 (es)
EC (1) ECSP088815A (es)
ES (1) ES2348829T3 (es)
IL (2) IL194453A0 (es)
ME (1) ME01143B (es)
MX (1) MX2008012655A (es)
NI (1) NI200800260A (es)
NO (1) NO341523B1 (es)
NZ (1) NZ571691A (es)
PE (1) PE20080130A1 (es)
PL (1) PL2007752T3 (es)
PT (1) PT2007752E (es)
RS (1) RS51423B (es)
SI (1) SI2007752T1 (es)
TW (1) TWI400234B (es)
UA (1) UA95949C2 (es)
UY (1) UY30253A1 (es)
WO (1) WO2007117399A2 (es)
ZA (1) ZA200809328B (es)

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