GB1062357A - Quinazolone derivatives - Google Patents
Quinazolone derivativesInfo
- Publication number
- GB1062357A GB1062357A GB32543/65A GB3254365A GB1062357A GB 1062357 A GB1062357 A GB 1062357A GB 32543/65 A GB32543/65 A GB 32543/65A GB 3254365 A GB3254365 A GB 3254365A GB 1062357 A GB1062357 A GB 1062357A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- amino
- alkenyl
- represent
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
Novel compounds of the general formula <FORM:1062357/C2/1> (wherein R1 and R2 each represent F, Cl, Br, CF3 or a C1- 4 alkyl, alkoxy or alkylthio group or one only of them may represent H, or R1 and R2 jointly represent a 6,7-methylenedioxy or ethylenedioxy radical, and R represents an amino, N-mono- or di-(alkyl, hydroxyalkyl or alkenyl)-amino, N-alkyl-N-(alkenyl, phenyl or p-tolyl)-amino, N-pyrryl, pyrrolidino, piperidino, homopiperidino, morpholino, piperazino, N1-(alkyl, hydroxyalkyl or phenyl)-piperazino or N-(1,2,3,4-tetrahydroisoquinolyl) group, each alkyl and alkenyl group in R containing not more than 5 carbon atoms), and their salts with pharmacologically acceptable acids and bases, are prepared by reacting a corresponding 2-halo-3,4 -dihydroquinazolin-4-one with an amino compound RH, and,if desired, converting the product into a salt by treatment with a nontoxic acid or base. R1,R2 - Substituted - 2 - halo - 3,4 - dihydroquinazolin-4-ones used as starting materials are prepared by treating the corresponding 2,4-dihaloquinazolines with a strong base in an aqueous or aqueous-organic reaction medium. Pharmaceutical preparations.-The quinazolones of the invention possess antihypertensive properties and may be administered orally or parenterally, e.g. in tablets, capsules, lozenges, troches, hard candies, powders, sprays, aqueous suspensions, injectable solutions, elixirs or syrups.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44220565A | 1965-03-23 | 1965-03-23 | |
US57654966A | 1966-09-01 | 1966-09-01 | |
US734770A | 1970-01-28 | 1970-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1062357A true GB1062357A (en) | 1967-03-22 |
Family
ID=27358345
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB32543/65A Expired GB1062357A (en) | 1965-03-23 | 1965-07-29 | Quinazolone derivatives |
GB09069/69A Expired GB1174273A (en) | 1965-03-23 | 1967-02-23 | Quinazoline Compounds |
GB8764/67A Expired GB1174272A (en) | 1965-03-23 | 1967-02-23 | Quinazoline Compounds |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB09069/69A Expired GB1174273A (en) | 1965-03-23 | 1967-02-23 | Quinazoline Compounds |
GB8764/67A Expired GB1174272A (en) | 1965-03-23 | 1967-02-23 | Quinazoline Compounds |
Country Status (5)
Country | Link |
---|---|
US (1) | US3609152A (en) |
BE (1) | BE678216A (en) |
DE (1) | DE1620127C3 (en) |
FR (1) | FR5267M (en) |
GB (3) | GB1062357A (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997042192A1 (en) * | 1996-05-07 | 1997-11-13 | Basf Aktiengesellschaft | Imidazoquinazolines, agents containing them and their use to combat fungi and animal pests |
WO2002053558A1 (en) * | 2001-01-02 | 2002-07-11 | F.Hoffman-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
WO2004031171A1 (en) | 2002-10-01 | 2004-04-15 | Mitsubishi Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
US6900220B2 (en) | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
WO2006003150A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Substituted 2-alkyl quinazolinone derivatives as parp inhibitors |
US7501412B2 (en) | 2002-11-22 | 2009-03-10 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
US8168644B2 (en) | 2008-03-27 | 2012-05-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
US8450486B2 (en) | 2003-11-20 | 2013-05-28 | Janssen Pharmaceutica, Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US8524714B2 (en) | 2003-11-20 | 2013-09-03 | Janssen Pharmaceutica, Nv | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US8623884B2 (en) | 2004-06-30 | 2014-01-07 | Janssen Pharmaceutica, Nv | Quinazolinedione derivatives as PARP inhibitors |
US8889866B2 (en) | 2008-03-27 | 2014-11-18 | Janssen Pharmaceutica, Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
US8946221B2 (en) | 2004-06-30 | 2015-02-03 | Janssen Pharmaceutica, Nv | Phthalazine derivatives as PARP inhibitors |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1383409A (en) * | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
DE2847693A1 (en) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | METHOD FOR PRODUCING PYRIMIDO- (6,1-A) -ISOCHINOLIN-2-ONES |
US4625026A (en) * | 1982-12-30 | 1986-11-25 | Biomeasure, Inc. | 2-amino-4-oxo-tricyclicpyrimidines having antiviral activities against herpes simplex virus type II infections |
US4814335A (en) * | 1982-12-30 | 1989-03-21 | Biomeasure, Incorporated | Antiviral compounds |
JPS6442472A (en) * | 1987-08-10 | 1989-02-14 | Kanebo Ltd | Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient |
US4877790A (en) * | 1987-12-15 | 1989-10-31 | Kanebo Limited | Quinazoline derivative, processes for its production, and cerebral dysfunction remedying agent comprising it as active ingredient |
TW334434B (en) * | 1995-05-16 | 1998-06-21 | Kanebo Ltd | Novel quinazoline compound and anti-tumor agent |
CN1209392C (en) * | 2001-05-14 | 2005-07-06 | 阿姆诺洼化学有限公司 | Polymeric surfactants derived from cyclic monomers having pendant fluorinated carbon groups |
EP1407774A1 (en) * | 2002-09-10 | 2004-04-14 | LION Bioscience AG | 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds |
EP1398032A1 (en) * | 2002-09-10 | 2004-03-17 | PheneX Pharmaceuticals AG | 4-Oxo-quinazolines as LXR nuclear receptor binding compounds |
NZ561489A (en) * | 2005-02-18 | 2010-10-29 | Mitsubishi Tanabe Pharma Corp | Salt of proline derivative, solvate thereof, and production method thereof |
BRPI0710083A2 (en) | 2006-03-31 | 2011-08-02 | Janssen Pharmaceutica Nv | benzoimidazol-2-yl pyrimidine and pyrazine chemical entity, pharmaceutical composition and use of these |
US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
AU2009267159B2 (en) * | 2008-06-30 | 2014-05-15 | Janssen Pharmaceutica Nv | Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives |
CA2746220A1 (en) | 2008-12-08 | 2010-07-08 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
US8987444B2 (en) * | 2010-01-18 | 2015-03-24 | Msn Laboratories Private Limited | Process for the preparation of amide intermediates and their use thereof |
EP2688884A1 (en) * | 2011-03-20 | 2014-01-29 | Cadila Healthcare Limited | Amorphous form of vilazodone hydrochloride and process for its preparation |
DE102011113749A1 (en) * | 2011-09-14 | 2013-03-14 | Aicuris Gmbh & Co. Kg | Sulfonic acid salts heterocyclylamide substituted imidazoles |
US8835417B2 (en) * | 2011-09-30 | 2014-09-16 | Janssen Pharmaceutica Nv | Crystalline hydrochloride salt of (1-(4-fluorophenyl)-1H-indol-5-yl)-(3-(4-(thiazole-2-carbonyl)piperazin-1-yl)azetidin-1-yl)methanone |
SG11201405692UA (en) | 2012-03-15 | 2014-10-30 | Celgene Avilomics Res Inc | Salts of an epidermal growth factor receptor kinase inhibitor |
SG11201405691WA (en) | 2012-03-15 | 2014-10-30 | Celgene Avilomics Res Inc | Solid forms of an epidermal growth factor receptor kinase inhibitor |
US20130261134A1 (en) * | 2012-03-30 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Mesylate salt forms of a potent hcv inhibitor |
TW201446745A (en) | 2013-02-08 | 2014-12-16 | Celgene Avilomics Res Inc | ERK inhibitors and uses thereof |
KR102230383B1 (en) | 2013-03-06 | 2021-03-23 | 얀센 파마슈티카 엔.브이. | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor |
US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
JP6634016B2 (en) * | 2013-12-03 | 2020-01-22 | アムジエン・インコーポレーテツド | Pharmaceutically acceptable N- (4-((3- (2-amino-4-pyrimidinyl) -2-pyridinyl) oxy) phenyl) -4- (4-methyl-2-thienyl) -1-phthalazineamine Forms of Salts Used and Their Use |
TW201613892A (en) | 2014-08-13 | 2016-04-16 | Celgene Avilomics Res Inc | Forms and compositions of an ERK inhibitor |
MA39286A (en) | 2014-09-17 | 2016-03-24 | Mundipharma International Corporation Ltd | CRYSTALLINE FORMS OF TYROSINE KINASE INHIBITORS AND THEIR SALTS |
CN112645932B (en) * | 2016-03-22 | 2022-01-14 | 江苏豪森药业集团有限公司 | Polymorphic forms of an EGFR inhibitor free base or an acid salt thereof, methods of making and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274194A (en) * | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
US3301855A (en) * | 1963-04-22 | 1967-01-31 | Ciba Geigy Corp | Derivatives of 4-nu-(2-nu, nu-dimethylaminolower alkyl)-amino quinazoline |
GB1053063A (en) * | 1963-05-18 | |||
US3257400A (en) * | 1964-06-10 | 1966-06-21 | Searle & Co | 2-amino-5, 6-dihydrobenzo[h]quinazolin-4(3h)-one and congeners |
-
1965
- 1965-07-29 GB GB32543/65A patent/GB1062357A/en not_active Expired
-
1966
- 1966-03-21 FR FR54286A patent/FR5267M/fr not_active Expired
- 1966-03-22 BE BE678216D patent/BE678216A/xx unknown
- 1966-03-22 DE DE1620127A patent/DE1620127C3/en not_active Expired
-
1967
- 1967-02-23 GB GB09069/69A patent/GB1174273A/en not_active Expired
- 1967-02-23 GB GB8764/67A patent/GB1174272A/en not_active Expired
-
1970
- 1970-01-28 US US7347A patent/US3609152A/en not_active Expired - Lifetime
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997042192A1 (en) * | 1996-05-07 | 1997-11-13 | Basf Aktiengesellschaft | Imidazoquinazolines, agents containing them and their use to combat fungi and animal pests |
WO2002053558A1 (en) * | 2001-01-02 | 2002-07-11 | F.Hoffman-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
US6900220B2 (en) | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
US7091200B2 (en) | 2001-01-02 | 2006-08-15 | Syntex U.S.A. Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
WO2004031171A1 (en) | 2002-10-01 | 2004-04-15 | Mitsubishi Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
US7220759B2 (en) | 2002-10-01 | 2007-05-22 | Mitsubishi Pharma Corporation | Isoquinoline compound and pharmaceutical use thereof |
US7459465B2 (en) | 2002-10-01 | 2008-12-02 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compound and pharmaceutical use thereof |
US7812178B2 (en) | 2002-10-01 | 2010-10-12 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compound and pharmaceutical use thereof |
US7501412B2 (en) | 2002-11-22 | 2009-03-10 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
US8524714B2 (en) | 2003-11-20 | 2013-09-03 | Janssen Pharmaceutica, Nv | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US8450486B2 (en) | 2003-11-20 | 2013-05-28 | Janssen Pharmaceutica, Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US10150757B2 (en) | 2004-06-30 | 2018-12-11 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as PARP inhibitors |
US9255080B2 (en) | 2004-06-30 | 2016-02-09 | Janssen Pharmaceutica Nv | Quinazolinedione derivatives as PARP inhibitors |
WO2006003150A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Substituted 2-alkyl quinazolinone derivatives as parp inhibitors |
US8623884B2 (en) | 2004-06-30 | 2014-01-07 | Janssen Pharmaceutica, Nv | Quinazolinedione derivatives as PARP inhibitors |
US8623872B2 (en) | 2004-06-30 | 2014-01-07 | Janssen Pharmaceutica, Nv | Quinazolinone derivatives as PARP inhibitors |
US9522905B2 (en) | 2004-06-30 | 2016-12-20 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as PARP inhibitors |
US8946221B2 (en) | 2004-06-30 | 2015-02-03 | Janssen Pharmaceutica, Nv | Phthalazine derivatives as PARP inhibitors |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
US8778966B2 (en) | 2007-03-08 | 2014-07-15 | Janssen Pharmaceutica, Nv | Quinolinone derivatives as PARP and tank inhibitors |
US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
US9150540B2 (en) | 2008-03-27 | 2015-10-06 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
US8889866B2 (en) | 2008-03-27 | 2014-11-18 | Janssen Pharmaceutica, Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
US9598396B2 (en) | 2008-03-27 | 2017-03-21 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
US8168644B2 (en) | 2008-03-27 | 2012-05-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
Also Published As
Publication number | Publication date |
---|---|
US3609152A (en) | 1971-09-28 |
GB1174272A (en) | 1969-12-17 |
GB1174273A (en) | 1969-12-17 |
DE1620127A1 (en) | 1970-03-12 |
DE1620127C3 (en) | 1974-10-10 |
DE1620127B2 (en) | 1974-01-17 |
FR5267M (en) | 1967-07-31 |
BE678216A (en) | 1966-09-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1062357A (en) | Quinazolone derivatives | |
HUT61289A (en) | Process for producing pyrimidine derivatives of sulfonamides and pharmaceutical compositions comprising same | |
GB1047935A (en) | Substituted piperazines and preparation thereof | |
CA2124680A1 (en) | Piperazine derivatives as 5-ht1a antagonists | |
CA2203274A1 (en) | Apolipoprotein-b synthesis inhibitors | |
GB1374366A (en) | Propanol derivatives and a process for their preparation | |
NO20001402L (en) | Substituted chrome derivatives | |
MY132062A (en) | Apolipoprotein-b synthesis inhibitors | |
IL26473A (en) | 1,4-bis(4-pyrimidylaminoalkyl)-piperazines and process for their manufacture | |
NZ223847A (en) | Substituted piperazine derivatives and pharmaceutical compositions | |
GB1077173A (en) | Substituted alkylene piperidines and methods of preparation thereof | |
GB1087875A (en) | Pyrazinoylguanidines | |
PT87277A (en) | PROCESS FOR THE PREPARATION OF NEW BICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | |
IE33862B1 (en) | Thiepin and oxepin derivatives,processes for their production and medicaments containing same | |
IE832581L (en) | Piperidinedione derivatives, possessing anti-arrythmic¹activity, for protecting the myocardium, process for their¹preparation and pharmaceutical compositions containing said¹derivatives | |
GB1106592A (en) | New asymmetrically di-n-substituted piperazines and process for their manufacture | |
GB1363195A (en) | Propenylamine derivatives and process for the production thereof | |
GB991589A (en) | Novel [1,2-ª‡]imidazopyridines and a process for the manufacture thereof | |
GB1495665A (en) | Pyrimidines | |
US3318895A (en) | Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines | |
US3410851A (en) | Derivatives of flavone | |
US3167556A (en) | Basic derivatives of anilides | |
GB1120186A (en) | Cyclohexene amino acid derivatives and process for their preparation | |
GB1093187A (en) | Dibenzothiadiazepine dioxide derivatives | |
ES8500923A1 (en) | Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them. |