MXPA03000431A - Proceso para preparar 4,6-dimetoxi-2-(metilsulfonil)-1,3-pirimidina. - Google Patents

Proceso para preparar 4,6-dimetoxi-2-(metilsulfonil)-1,3-pirimidina.

Info

Publication number
MXPA03000431A
MXPA03000431A MXPA03000431A MXPA03000431A MXPA03000431A MX PA03000431 A MXPA03000431 A MX PA03000431A MX PA03000431 A MXPA03000431 A MX PA03000431A MX PA03000431 A MXPA03000431 A MX PA03000431A MX PA03000431 A MXPA03000431 A MX PA03000431A
Authority
MX
Mexico
Prior art keywords
dimethoxy
pyrimidine
methylsulfonyl
aqueous
compound
Prior art date
Application number
MXPA03000431A
Other languages
English (en)
Inventor
Bernhard Urwyler
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of MXPA03000431A publication Critical patent/MXPA03000431A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Un proceso para preparar 4,6-dimetoxi-2- (metilsulfonil)-1,3-pirimidina al hacer reaccionar la 4,6-dicloro-2-(metiltio)-1,3-pirimidina en un solvente orgánico inerte con un metoxido de metal alcalino, transferir la 4,6-dimetoxi-2-(metiltio)-1,3-pirimidina resultante en un medio acuoso-ácido, y la subsiguiente oxidacion de este compuesto, si es adecuado en presencia de un catalizador, en donde la oxidacion es seguida por un paso de purificacion en el cual se ajusta el pH de la mezcla de reaccion acuosa-ácida mediante una base acuosa en un intervalo entre 5-8, y se agita en la presencia o en la ausencia de un solvente orgánico, y el uso de este compuesto para preparar herbicidas, por ejemplo la 7-[(4,6-dimetoxipirimidin-2-il)tio]-3-metilftalida.
MXPA03000431A 2000-07-21 2001-07-19 Proceso para preparar 4,6-dimetoxi-2-(metilsulfonil)-1,3-pirimidina. MXPA03000431A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH14392000 2000-07-21
PCT/EP2001/008373 WO2002008207A1 (en) 2000-07-21 2001-07-19 Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine

Publications (1)

Publication Number Publication Date
MXPA03000431A true MXPA03000431A (es) 2003-06-24

Family

ID=4565478

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000431A MXPA03000431A (es) 2000-07-21 2001-07-19 Proceso para preparar 4,6-dimetoxi-2-(metilsulfonil)-1,3-pirimidina.

Country Status (18)

Country Link
US (1) US6693194B2 (es)
EP (1) EP1301491A1 (es)
JP (1) JP3507483B1 (es)
KR (1) KR100516535B1 (es)
CN (1) CN1285581C (es)
AR (1) AR033677A1 (es)
AU (2) AU2001289701B2 (es)
BR (1) BR0112712A (es)
CA (1) CA2411155C (es)
HU (1) HUP0301038A3 (es)
IL (1) IL153662A0 (es)
MX (1) MXPA03000431A (es)
PL (1) PL362686A1 (es)
RU (1) RU2276142C2 (es)
TW (1) TWI288132B (es)
UA (1) UA75888C2 (es)
WO (1) WO2002008207A1 (es)
ZA (1) ZA200300510B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1786430T3 (pl) 2004-08-20 2013-09-30 Buck Institute For Age Res Małe cząsteczki, które zastępują lub działają agonistycznie do funkcji p53
DK2007752T3 (da) 2006-03-31 2010-11-15 Janssen Pharmaceutica Nv Benzimidazol-2-yl-pyrimidiner og -pyraziner som modulatorer af histamin H4-receptoren
EP2769721A3 (en) 2008-06-30 2015-04-01 Janssen Pharmaceutica N.V. Process for the preparation of substituted pyrimidine derivatives
CN102137857A (zh) 2008-06-30 2011-07-27 詹森药业有限公司 用于制备苯并咪唑-2-基嘧啶衍生物的方法
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
CN101747283B (zh) * 2008-12-11 2011-06-08 中国中化股份有限公司 一种制备4，6-二甲氧基-2-甲磺酰基嘧啶的方法
WO2014128719A2 (en) * 2013-02-18 2014-08-28 Gharda Chemicals Ltd Processes for the preparation of bispyribac sodium and intermediates thereof
ES2773543T3 (es) 2013-03-06 2020-07-13 Janssen Pharmaceutica Nv Benzoimidazol-2-ilpirimidinas moduladores del receptor de histamina H4
CN112552244A (zh) * 2020-12-22 2021-03-26 内蒙古科硕新材料科技有限公司 一种4,6-二甲氧基-2-甲磺酰基嘧啶的生产工艺
CN115215805B (zh) * 2022-08-11 2024-06-25 上海奥萝拉医药科技有限公司 一种2-氰基嘧啶的制备工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525977A1 (de) 1985-07-20 1987-01-29 Bayer Ag Verfahren zur herstellung von 2-cyanamino-pyrimidin-derivaten
JP2561480B2 (ja) 1987-08-06 1996-12-11 イハラケミカル工業株式会社 ４，６−ジアルコキシ−２−アルキルチオピリミジン類の製造方法
US5149357A (en) 1990-06-19 1992-09-22 Fmc Corporation Herbicidal substituted benzoylsulfonamides
TWI220428B (en) 1999-02-05 2004-08-21 Syngenta Participations Ag Method of producing thiobarbituric acid derivatives

Also Published As

Publication number Publication date
TWI288132B (en) 2007-10-11
CN1443175A (zh) 2003-09-17
WO2002008207A1 (en) 2002-01-31
JP2004504387A (ja) 2004-02-12
CA2411155C (en) 2009-12-08
AU2001289701B2 (en) 2004-06-24
ZA200300510B (en) 2004-04-20
IL153662A0 (en) 2003-07-06
JP3507483B1 (ja) 2004-03-15
AU8970101A (en) 2002-02-05
HUP0301038A3 (en) 2004-06-28
KR20030047992A (ko) 2003-06-18
HUP0301038A2 (hu) 2003-08-28
KR100516535B1 (ko) 2005-09-22
PL362686A1 (en) 2004-11-02
UA75888C2 (uk) 2006-06-15
CA2411155A1 (en) 2002-01-31
US20030135047A1 (en) 2003-07-17
RU2276142C2 (ru) 2006-05-10
CN1285581C (zh) 2006-11-22
US6693194B2 (en) 2004-02-17
AR033677A1 (es) 2004-01-07
EP1301491A1 (en) 2003-04-16
BR0112712A (pt) 2003-05-20

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