HUP0301038A2 - Eljárás 4,6-dimetoxi-2-(metil-szulfonil)-1,3-pirimidin elõállítására - Google Patents
Eljárás 4,6-dimetoxi-2-(metil-szulfonil)-1,3-pirimidin elõállításáraInfo
- Publication number
- HUP0301038A2 HUP0301038A2 HU0301038A HUP0301038A HUP0301038A2 HU P0301038 A2 HUP0301038 A2 HU P0301038A2 HU 0301038 A HU0301038 A HU 0301038A HU P0301038 A HUP0301038 A HU P0301038A HU P0301038 A2 HUP0301038 A2 HU P0301038A2
- Authority
- HU
- Hungary
- Prior art keywords
- pyrimidine
- dimethoxy
- aqueous
- methylsulfonyl
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- RRKHIAYNPVQKEF-UHFFFAOYSA-N Pyriftalid Chemical compound COC1=CC(OC)=NC(SC=2C=3C(=O)OC(C)C=3C=CC=2)=N1 RRKHIAYNPVQKEF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal methoxide Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány egy eljárásra vonatkozik 4,6-dimetoxi-2-(metil-szulfonil)-1,3-pirimidin előállítására a 4,6-diklór-2-(metiltio)-1,3-pirimidinsemleges szerves oldószerben alkálifém metoxiddal történőreagáltatásával, a keletkezett 4,6-dimetoxi-2-(metiltio)-1,3-pirimidinátvitelével egy vizes-savas közegbe, ahol a továbbiakban ennek avegyületeknek az oxidációja történik meg, ha szükséges, akkorkatalizátor jelenlétében, amely eljárásban az oxidációt egy tisztításilépés követi, amelyben a vizes-savas reakcióelegy pH-ját vizesbázissal beállítják az 5-8 tartományba, és az elegyet szerves oldószerjelenlétében vagy anélkül keverik. A találmány ennek a vegyületnek azalkalmazására is vonatkozik gyomirtó szerek, például 7-[(4,6-dimetoxi-pirimidin-2-il)-tio]-3-metil-ftalid előállítására. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH14392000 | 2000-07-21 | ||
| PCT/EP2001/008373 WO2002008207A1 (en) | 2000-07-21 | 2001-07-19 | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0301038A2 true HUP0301038A2 (hu) | 2003-08-28 |
| HUP0301038A3 HUP0301038A3 (en) | 2004-06-28 |
Family
ID=4565478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301038A HUP0301038A3 (en) | 2000-07-21 | 2001-07-19 | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6693194B2 (hu) |
| EP (1) | EP1301491A1 (hu) |
| JP (1) | JP3507483B1 (hu) |
| KR (1) | KR100516535B1 (hu) |
| CN (1) | CN1285581C (hu) |
| AR (1) | AR033677A1 (hu) |
| AU (2) | AU2001289701B2 (hu) |
| BR (1) | BR0112712A (hu) |
| CA (1) | CA2411155C (hu) |
| HU (1) | HUP0301038A3 (hu) |
| IL (1) | IL153662A0 (hu) |
| MX (1) | MXPA03000431A (hu) |
| PL (1) | PL362686A1 (hu) |
| RU (1) | RU2276142C2 (hu) |
| TW (1) | TWI288132B (hu) |
| UA (1) | UA75888C2 (hu) |
| WO (1) | WO2002008207A1 (hu) |
| ZA (1) | ZA200300510B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1786430T3 (pl) | 2004-08-20 | 2013-09-30 | Buck Institute For Age Res | Małe cząsteczki, które zastępują lub działają agonistycznie do funkcji p53 |
| PE20080130A1 (es) | 2006-03-31 | 2008-02-25 | Janssen Pharmaceutica Nv | Benzoimidazol-2-il pirimidinas y pirazinas como moduladores del receptor h4 de histamina |
| EA019361B1 (ru) | 2008-06-30 | 2014-03-31 | Янссен Фармацевтика Нв | Способ получения замещенных пиримидиновых производных |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| NZ590169A (en) | 2008-06-30 | 2012-05-25 | Janssen Pharmaceutica Nv | Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives |
| CN101747283B (zh) * | 2008-12-11 | 2011-06-08 | 中国中化股份有限公司 | 一种制备4，6-二甲氧基-2-甲磺酰基嘧啶的方法 |
| BR112015019795B1 (pt) * | 2013-02-18 | 2020-06-16 | Gharda Chemicals Ltd | Processo para a preparação de bispiribac de sódio e intermediários do mesmo |
| UY35370A (es) | 2013-03-06 | 2014-09-30 | Janssen Pharmaceutica Nv | Moduladores benzoimidazol-2-il pirimidina del receptor de histamina h4 |
| CN112552244A (zh) * | 2020-12-22 | 2021-03-26 | 内蒙古科硕新材料科技有限公司 | 一种4,6-二甲氧基-2-甲磺酰基嘧啶的生产工艺 |
| CN115215805B (zh) * | 2022-08-11 | 2024-06-25 | 上海奥萝拉医药科技有限公司 | 一种2-氰基嘧啶的制备工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3525977A1 (de) | 1985-07-20 | 1987-01-29 | Bayer Ag | Verfahren zur herstellung von 2-cyanamino-pyrimidin-derivaten |
| JP2561480B2 (ja) | 1987-08-06 | 1996-12-11 | イハラケミカル工業株式会社 | ４，６−ジアルコキシ−２−アルキルチオピリミジン類の製造方法 |
| US5149357A (en) * | 1990-06-19 | 1992-09-22 | Fmc Corporation | Herbicidal substituted benzoylsulfonamides |
| TWI220428B (en) * | 1999-02-05 | 2004-08-21 | Syngenta Participations Ag | Method of producing thiobarbituric acid derivatives |
-
2001
- 2001-07-19 RU RU2003104800/04A patent/RU2276142C2/ru not_active IP Right Cessation
- 2001-07-19 MX MXPA03000431A patent/MXPA03000431A/es active IP Right Grant
- 2001-07-19 UA UA2003021454A patent/UA75888C2/uk unknown
- 2001-07-19 IL IL15366201A patent/IL153662A0/xx unknown
- 2001-07-19 PL PL01362686A patent/PL362686A1/xx not_active Application Discontinuation
- 2001-07-19 AU AU2001289701A patent/AU2001289701B2/en not_active Ceased
- 2001-07-19 WO PCT/EP2001/008373 patent/WO2002008207A1/en active IP Right Grant
- 2001-07-19 CN CNB018131492A patent/CN1285581C/zh not_active Expired - Fee Related
- 2001-07-19 CA CA002411155A patent/CA2411155C/en not_active Expired - Fee Related
- 2001-07-19 BR BR0112712-8A patent/BR0112712A/pt not_active Application Discontinuation
- 2001-07-19 TW TW090117644A patent/TWI288132B/zh not_active IP Right Cessation
- 2001-07-19 EP EP01969442A patent/EP1301491A1/en not_active Ceased
- 2001-07-19 HU HU0301038A patent/HUP0301038A3/hu not_active Application Discontinuation
- 2001-07-19 AU AU8970101A patent/AU8970101A/xx active Pending
- 2001-07-19 JP JP2002514113A patent/JP3507483B1/ja not_active Expired - Fee Related
- 2001-07-19 US US10/332,248 patent/US6693194B2/en not_active Expired - Lifetime
- 2001-07-19 KR KR10-2003-7000881A patent/KR100516535B1/ko not_active IP Right Cessation
- 2001-07-20 AR ARP010103448A patent/AR033677A1/es not_active Application Discontinuation
-
2003
- 2003-01-20 ZA ZA200300510A patent/ZA200300510B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8970101A (en) | 2002-02-05 |
| MXPA03000431A (es) | 2003-06-24 |
| WO2002008207A1 (en) | 2002-01-31 |
| KR100516535B1 (ko) | 2005-09-22 |
| RU2276142C2 (ru) | 2006-05-10 |
| TWI288132B (en) | 2007-10-11 |
| PL362686A1 (en) | 2004-11-02 |
| IL153662A0 (en) | 2003-07-06 |
| KR20030047992A (ko) | 2003-06-18 |
| CN1443175A (zh) | 2003-09-17 |
| AU2001289701B2 (en) | 2004-06-24 |
| ZA200300510B (en) | 2004-04-20 |
| CN1285581C (zh) | 2006-11-22 |
| EP1301491A1 (en) | 2003-04-16 |
| JP2004504387A (ja) | 2004-02-12 |
| CA2411155C (en) | 2009-12-08 |
| US6693194B2 (en) | 2004-02-17 |
| JP3507483B1 (ja) | 2004-03-15 |
| AR033677A1 (es) | 2004-01-07 |
| US20030135047A1 (en) | 2003-07-17 |
| CA2411155A1 (en) | 2002-01-31 |
| BR0112712A (pt) | 2003-05-20 |
| HUP0301038A3 (en) | 2004-06-28 |
| UA75888C2 (uk) | 2006-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9915938A (pt) | Derivados de pirimidina substituìdos por arila e heterociclila como anticoagulantes | |
| ATE241625T1 (de) | Heterocyclische verbindungen, ihre herstellung und verwendung | |
| DK1040108T3 (da) | Orthoanthranilamidderivater som antikoagulanter | |
| AU1282495A (en) | Anthranilic acid derivative | |
| HUP0301038A2 (hu) | Eljárás 4,6-dimetoxi-2-(metil-szulfonil)-1,3-pirimidin elõállítására | |
| DK1295890T3 (da) | Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge | |
| PT718293E (pt) | Composto ciclodepsipeptidico | |
| ATE347555T1 (de) | 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung | |
| ATE280767T1 (de) | Antidiabetische thiazolidindione und ihre herstellung | |
| EA200600046A1 (ru) | Производные 6-[2-(фосфонометокси)алкокси]пиримидинов (варианты), способ их получения (варианты), фармацевтическая композиция на их основе и способ лечения вирусной инфекции | |
| DE60013994D1 (de) | 1,2-Disubstituierte 1,4-Dihydro-4-oxochinolin-Verbindungen | |
| WO2002079753A3 (en) | 2-aminobenzoxazole derivatives and combinatorial libraries thereof | |
| IL157216A0 (en) | Crystalline forms of pyrimidine nucleoside derivatives and pharmaceutical compositions containing the same | |
| HRP20010798B1 (en) | Processes for preparing pesticidal intermediates | |
| JP2004504387A5 (hu) | ||
| FR2803846B1 (fr) | 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation | |
| DK1178985T3 (da) | Substituerede thienocycloalk(en)ylamino-1,3,5-triaziner | |
| HUP0104213A2 (hu) | Vankoreszmicin, eljárás előállítására és gyógyszerként történő alkalmazása | |
| BR0008029B1 (pt) | método de produzir derivados de ácido tiobarbitúrico. | |
| NZ505406A (en) | Processes and intermediates useful to make antifolates | |
| DK0713702T3 (da) | Anxiolytisk middel | |
| EP1065202A4 (en) | 6- (ALPHA-FLUOROALKYL) -4-PYRIMIDONES AND THEIR PRODUCTION PROCESS | |
| TH51879B (th) | กระบวนการเตรียม 4, 6-ไดเมธอกซี-2-(เมธิลซัลโฟนิล)-1, 3-ไพริมิดีน | |
| PT1421064E (pt) | Processo para a preparacao de derivados de 3-espiro'ciclohexan-1,3'-'3h}indolin-2'-ona} | |
| AU2002360015A1 (en) | 2-substituted vitamin d derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC4A | Lapse of provisional application due to refusal |