FR2803846B1 - 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation - Google Patents

3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation

Info

Publication number
FR2803846B1
FR2803846B1 FR0000523A FR0000523A FR2803846B1 FR 2803846 B1 FR2803846 B1 FR 2803846B1 FR 0000523 A FR0000523 A FR 0000523A FR 0000523 A FR0000523 A FR 0000523A FR 2803846 B1 FR2803846 B1 FR 2803846B1
Authority
FR
France
Prior art keywords
pentylidene
benzofuran
nitro
hydroxy
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0000523A
Other languages
English (en)
Other versions
FR2803846A1 (fr
Inventor
Alain Schouteeten
Francoise Mordacq
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clariant France SA
Original Assignee
Clariant France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant France SA filed Critical Clariant France SA
Priority to FR0000523A priority Critical patent/FR2803846B1/fr
Priority to TW090100495A priority patent/TW564246B/zh
Priority to ES01810033T priority patent/ES2238408T3/es
Priority to DE60109829T priority patent/DE60109829T2/de
Priority to AT01810033T priority patent/ATE292630T1/de
Priority to HU0100146A priority patent/HUP0100146A3/hu
Priority to EP01810033A priority patent/EP1116719B1/fr
Priority to DK01810033T priority patent/DK1116719T3/da
Priority to NO20010265A priority patent/NO327039B1/no
Priority to KR1020010002333A priority patent/KR100788529B1/ko
Priority to JP2001007465A priority patent/JP4408578B2/ja
Priority to CNB01101296XA priority patent/CN1204133C/zh
Priority to US09/761,452 priority patent/US6515147B2/en
Publication of FR2803846A1 publication Critical patent/FR2803846A1/fr
Application granted granted Critical
Publication of FR2803846B1 publication Critical patent/FR2803846B1/fr
Priority to US11/050,627 priority patent/USRE39755E1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
FR0000523A 2000-01-17 2000-01-17 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation Expired - Fee Related FR2803846B1 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR0000523A FR2803846B1 (fr) 2000-01-17 2000-01-17 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation
TW090100495A TW564246B (en) 2000-01-17 2001-01-10 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation thereof and the use thereof
DE60109829T DE60109829T2 (de) 2000-01-17 2001-01-15 3-(1-Hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-on, ein Verfahren zu seiner Herstellung und seine Verwendung
AT01810033T ATE292630T1 (de) 2000-01-17 2001-01-15 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran 2-on, ein verfahren zu seiner herstellung und seine verwendung
HU0100146A HUP0100146A3 (en) 2000-01-17 2001-01-15 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, process for its preparation and use thereof
EP01810033A EP1116719B1 (fr) 2000-01-17 2001-01-15 3-(1-Hydroxy-pentylidène)-5-nitro-3H-benzofuran-2-one, procédé de sa préparation et son utilisation
DK01810033T DK1116719T3 (da) 2000-01-17 2001-01-15 3-(1-hydroxy-pentyliden)-5-nitro-3H-benzofuran-2-on, fremgangsmåde til fremstilling deraf og anvendelse deraf
ES01810033T ES2238408T3 (es) 2000-01-17 2001-01-15 3-(1-hidroxi-pentiliden)-5-nitro-3h-benzofuran-2-ona, procedimiento para su preparacion y uso de la misma.
NO20010265A NO327039B1 (no) 2000-01-17 2001-01-16 3-(1-hydroksy-pentyliden)-5-nitro-3H-benzofuran-2-on, fremgangsmate for fremstilling og anvendelse derav
KR1020010002333A KR100788529B1 (ko) 2000-01-17 2001-01-16 3-(1-히드록시-펜틸리덴)-5-니트로-3ｈ-벤조푸란-2-온,그의 제조 방법 및 용도
JP2001007465A JP4408578B2 (ja) 2000-01-17 2001-01-16 ３−（１−ヒドロキシ−ペンチリデン）−５−ニトロ−３ｈ−ベンゾフラン−２−オン、その製造方法及びその用途
CNB01101296XA CN1204133C (zh) 2000-01-17 2001-01-17 3－(1－羟基－亚戊基)－5－硝基－3h－苯并呋喃－2－酮,其制备方法及用途
US09/761,452 US6515147B2 (en) 2000-01-17 2001-01-17 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof
US11/050,627 USRE39755E1 (en) 2000-01-17 2005-02-03 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0000523A FR2803846B1 (fr) 2000-01-17 2000-01-17 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation

Publications (2)

Publication Number Publication Date
FR2803846A1 FR2803846A1 (fr) 2001-07-20
FR2803846B1 true FR2803846B1 (fr) 2002-04-05

Family

ID=8845968

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0000523A Expired - Fee Related FR2803846B1 (fr) 2000-01-17 2000-01-17 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation

Country Status (13)

Country Link
US (2) US6515147B2 (fr)
EP (1) EP1116719B1 (fr)
JP (1) JP4408578B2 (fr)
KR (1) KR100788529B1 (fr)
CN (1) CN1204133C (fr)
AT (1) ATE292630T1 (fr)
DE (1) DE60109829T2 (fr)
DK (1) DK1116719T3 (fr)
ES (1) ES2238408T3 (fr)
FR (1) FR2803846B1 (fr)
HU (1) HUP0100146A3 (fr)
NO (1) NO327039B1 (fr)
TW (1) TW564246B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237819A1 (de) * 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
FR2864536B1 (fr) * 2003-12-24 2006-03-17 Clariant France Sa Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
TWI519298B (zh) 2008-04-17 2016-02-01 賽諾菲 安萬特公司 決奈達隆（ｄｒｏｎｅｄａｒｏｎｅ）於製備用於預防心血管疾病住院或死亡之藥劑之用途
FR2930149B1 (fr) * 2008-04-17 2011-02-18 Sanofi Aventis Association de dronedarone avec au moins un diuretique, son application en therapeutique
EP2116239A1 (fr) * 2008-04-29 2009-11-11 Sanofi-Aventis Procédé pour la gestion des risques associés à une augmentation de la créatinine sérique pendant un traitement à la dronédarone
EP2246341A1 (fr) 2009-01-23 2010-11-03 Lonza Ltd. Processus de préparation de 2-Alkyl-3-aroyl-5-nitro-benzofuranes
CN102276561A (zh) * 2010-06-09 2011-12-14 江苏恒瑞医药股份有限公司 决奈达隆及其盐的制备方法
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
US4252817A (en) * 1975-03-12 1981-02-24 Sandoz Ltd. Substituted-2,3-dihydrobenzofuran-2-ones
FR2642755B1 (fr) * 1989-02-07 1993-11-05 Sanofi
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands

Also Published As

Publication number Publication date
DK1116719T3 (da) 2005-07-18
NO327039B1 (no) 2009-04-06
US20010012900A1 (en) 2001-08-09
NO20010265D0 (no) 2001-01-16
FR2803846A1 (fr) 2001-07-20
US6515147B2 (en) 2003-02-04
NO20010265L (no) 2001-07-18
TW564246B (en) 2003-12-01
EP1116719A2 (fr) 2001-07-18
HU0100146D0 (en) 2001-03-28
ES2238408T3 (es) 2005-09-01
KR20010076278A (ko) 2001-08-11
JP4408578B2 (ja) 2010-02-03
ATE292630T1 (de) 2005-04-15
HUP0100146A2 (hu) 2002-01-28
EP1116719A3 (fr) 2001-10-24
CN1204133C (zh) 2005-06-01
KR100788529B1 (ko) 2007-12-24
CN1306000A (zh) 2001-08-01
JP2001233870A (ja) 2001-08-28
USRE39755E1 (en) 2007-07-31
EP1116719B1 (fr) 2005-04-06
DE60109829T2 (de) 2006-01-19
DE60109829D1 (de) 2005-05-12
HUP0100146A3 (en) 2003-07-28

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Effective date: 20110930