BR0210030A - Derivado de fenilpiridinacarbonilpiperazina - Google Patents

Derivado de fenilpiridinacarbonilpiperazina

Info

Publication number
BR0210030A
BR0210030A BR0210030-4A BR0210030A BR0210030A BR 0210030 A BR0210030 A BR 0210030A BR 0210030 A BR0210030 A BR 0210030A BR 0210030 A BR0210030 A BR 0210030A
Authority
BR
Brazil
Prior art keywords
hydrogen
phenylpyridinecarbonylpiperazine
derivative
lower alkyl
halogen
Prior art date
Application number
BR0210030-4A
Other languages
English (en)
Inventor
Masahiro Iwata
Noriyuki Kawano
Hiroyuki Kaizawa
Tomofumi Takuwa
Issei Tsukamoto
Ryushi Seo
Kiyoshi Yahiro
Miki Kobayashi
Makoto Takeuchi
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of BR0210030A publication Critical patent/BR0210030A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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Abstract

"DERIVADO DE FENILPIRIDINACARBONILPIPERAZINA". Para fornecer um composto que pode ser utilizado para prevenção/tratamento de doenças respiratórias onde a fosfodiesterase do tipo 4 participa, especialmente, na asma brónquica ou doença pulmonar obstrutiva crónica, etc. Um derivado da piridina que possui um grupo fenila na posição 6, um grupo piperazinacarbonila na posição 2, etc., ou um seu sal.
BR0210030-4A 2001-06-15 2002-06-13 Derivado de fenilpiridinacarbonilpiperazina BR0210030A (pt)

Applications Claiming Priority (2)

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JP2001182296 2001-06-15
PCT/JP2002/005926 WO2002102778A1 (fr) 2001-06-15 2002-06-13 Derive de phenylpyridinecarbonylpiperazine

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EP (1) EP1396487B1 (pt)
KR (1) KR20040010713A (pt)
CN (1) CN1300114C (pt)
AT (1) ATE417038T1 (pt)
BR (1) BR0210030A (pt)
CA (1) CA2448298A1 (pt)
DE (1) DE60230266D1 (pt)
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DE60230266D1 (de) 2009-01-22
MXPA03011629A (es) 2004-07-01
CA2448298A1 (en) 2002-12-27
WO2002102778A1 (fr) 2002-12-27
ATE417038T1 (de) 2008-12-15
CN1516691A (zh) 2004-07-28
ES2316575T3 (es) 2009-04-16
RU2003136097A (ru) 2005-05-20
PL367205A1 (en) 2005-02-21
RU2285002C2 (ru) 2006-10-10
KR20040010713A (ko) 2004-01-31
CN1300114C (zh) 2007-02-14
EP1396487A4 (en) 2006-06-14
EP1396487A1 (en) 2004-03-10
US20040192701A1 (en) 2004-09-30
EP1396487B1 (en) 2008-12-10
US7196080B2 (en) 2007-03-27

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