PL1692098T3 - Pochodna alfa-ketomidu oraz sposób jej wytwarzania i zastosowanie - Google Patents
Pochodna alfa-ketomidu oraz sposób jej wytwarzania i zastosowanieInfo
- Publication number
- PL1692098T3 PL1692098T3 PL04807051T PL04807051T PL1692098T3 PL 1692098 T3 PL1692098 T3 PL 1692098T3 PL 04807051 T PL04807051 T PL 04807051T PL 04807051 T PL04807051 T PL 04807051T PL 1692098 T3 PL1692098 T3 PL 1692098T3
- Authority
- PL
- Poland
- Prior art keywords
- lower alkyl
- alpha
- production method
- phenyl
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
- Pens And Brushes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003415764 | 2003-12-12 | ||
| JP2004234164 | 2004-08-11 | ||
| PCT/JP2004/018692 WO2005056519A1 (en) | 2003-12-12 | 2004-12-08 | Alpha-ketoamide derivative, and production method and use thereof |
| EP04807051A EP1692098B1 (en) | 2003-12-12 | 2004-12-08 | Alpha-ketoamide derivative, and production method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1692098T3 true PL1692098T3 (pl) | 2010-03-31 |
Family
ID=34680644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04807051T PL1692098T3 (pl) | 2003-12-12 | 2004-12-08 | Pochodna alfa-ketomidu oraz sposób jej wytwarzania i zastosowanie |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7491705B2 (pl) |
| EP (1) | EP1692098B1 (pl) |
| KR (1) | KR101055236B1 (pl) |
| AT (1) | ATE446948T1 (pl) |
| DE (1) | DE602004023873D1 (pl) |
| ES (1) | ES2331841T3 (pl) |
| PL (1) | PL1692098T3 (pl) |
| WO (1) | WO2005056519A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009114151A1 (en) * | 2008-03-12 | 2009-09-17 | Nektar Therapeutics | Oligomer-amino acid and olgomer-atazanavir conjugates |
| WO2011105070A1 (ja) | 2010-02-25 | 2011-09-01 | パナソニック株式会社 | 需給制御装置、需給制御方法、およびプログラム |
| EP2593089B1 (en) | 2010-07-14 | 2018-04-04 | Senju Pharmaceutical Co., Ltd. | Solid dispersion of alfa-ketoamide derivative |
| US9539298B2 (en) | 2010-11-29 | 2017-01-10 | Osaka City University | Lissencephaly therapeutic agent |
| US9371359B2 (en) | 2010-11-29 | 2016-06-21 | Osaka City University | Lissencephaly therapeutic agent |
| JP6407257B2 (ja) | 2014-03-31 | 2018-10-17 | 千寿製薬株式会社 | アルキニルインダゾール誘導体及びその用途 |
| EA031266B1 (ru) | 2014-09-08 | 2018-12-28 | Ландштейнер Хенмед, С.Л. | Дипептидилкетоамидные соединения и их применение для лечения и/или предотвращения накопления жира |
| CN107018651A (zh) * | 2014-11-11 | 2017-08-04 | 健康科学西部大学 | 同种型特异性钙蛋白酶抑制剂及其识别方法和用途 |
| EP3452034B1 (en) | 2016-05-06 | 2024-05-15 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Calpain inhibitors in the prevention and/or treatment of ventricular remodelling |
| US11844776B2 (en) | 2016-05-23 | 2023-12-19 | Osaka City University | Composition for treatment and/or prevention of peripheral nerve disorder |
| EP3564211A1 (en) | 2018-05-03 | 2019-11-06 | Landsteiner Genmed, S.L. | Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992012140A1 (en) | 1990-12-28 | 1992-07-23 | Georgia Tech Research Corporation | Peptides ketoamides, ketoacids, and ketoesters |
| US5444042A (en) | 1990-12-28 | 1995-08-22 | Cortex Pharmaceuticals | Method of treatment of neurodegeneration with calpain inhibitors |
| US6235929B1 (en) | 1991-12-27 | 2001-05-22 | Georgia Tech Research Corporation | Tripeptide α-ketoamides |
| US5650508A (en) | 1991-12-27 | 1997-07-22 | Georgia Tech Research Corporation | Peptide ketoamides |
| CA2138124A1 (en) * | 1992-06-24 | 1994-01-06 | David D. Eveleth, Jr. | Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity |
| US5514694A (en) | 1992-09-21 | 1996-05-07 | Georgia Tech Research Corp | Peptidyl ketoamides |
| US5541290A (en) * | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
| JP2825198B2 (ja) * | 1995-09-01 | 1998-11-18 | 本田技研工業株式会社 | 車両用無段変速機構の油圧制御装置 |
| US5763576A (en) * | 1995-10-06 | 1998-06-09 | Georgia Tech Research Corp. | Tetrapeptide α-ketoamides |
| DE19718826A1 (de) * | 1997-05-05 | 1998-11-12 | Marion S Dr Eckmiller | Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung |
| US6150378A (en) | 1997-10-07 | 2000-11-21 | Cephalon, Inc. | Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors |
| US6686335B1 (en) * | 1998-09-22 | 2004-02-03 | Cephalon, Inc. | Hydroxamate-containing cysteine and serine protease inhibitors |
| EP1370240A4 (en) | 2001-03-02 | 2004-09-22 | Neuron Therapeutics Inc | NEUROPROTECTOR FORMULATIONS AND METHOD |
-
2004
- 2004-12-08 DE DE602004023873T patent/DE602004023873D1/de active Active
- 2004-12-08 AT AT04807051T patent/ATE446948T1/de active
- 2004-12-08 US US10/582,015 patent/US7491705B2/en active Active
- 2004-12-08 KR KR1020067009234A patent/KR101055236B1/ko not_active IP Right Cessation
- 2004-12-08 PL PL04807051T patent/PL1692098T3/pl unknown
- 2004-12-08 EP EP04807051A patent/EP1692098B1/en active Active
- 2004-12-08 ES ES04807051T patent/ES2331841T3/es active Active
- 2004-12-08 WO PCT/JP2004/018692 patent/WO2005056519A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| KR101055236B1 (ko) | 2011-08-08 |
| EP1692098A1 (en) | 2006-08-23 |
| ATE446948T1 (de) | 2009-11-15 |
| DE602004023873D1 (de) | 2009-12-10 |
| WO2005056519A1 (en) | 2005-06-23 |
| KR20060134929A (ko) | 2006-12-28 |
| EP1692098B1 (en) | 2009-10-28 |
| ES2331841T3 (es) | 2010-01-18 |
| US20070004643A1 (en) | 2007-01-04 |
| US7491705B2 (en) | 2009-02-17 |
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