ATE446948T1 - Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon - Google Patents

Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon

Info

Publication number
ATE446948T1
ATE446948T1 AT04807051T AT04807051T ATE446948T1 AT E446948 T1 ATE446948 T1 AT E446948T1 AT 04807051 T AT04807051 T AT 04807051T AT 04807051 T AT04807051 T AT 04807051T AT E446948 T1 ATE446948 T1 AT E446948T1
Authority
AT
Austria
Prior art keywords
lower alkyl
alpha
production method
phenyl
optionally substituted
Prior art date
Application number
AT04807051T
Other languages
English (en)
Inventor
Yoshihisa Shirasaki
Hiroyuki Miyashita
Masayuki Nakamura
Jun Inoue
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Application granted granted Critical
Publication of ATE446948T1 publication Critical patent/ATE446948T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Pens And Brushes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04807051T 2003-12-12 2004-12-08 Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon ATE446948T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003415764 2003-12-12
JP2004234164 2004-08-11
PCT/JP2004/018692 WO2005056519A1 (en) 2003-12-12 2004-12-08 Alpha-ketoamide derivative, and production method and use thereof

Publications (1)

Publication Number Publication Date
ATE446948T1 true ATE446948T1 (de) 2009-11-15

Family

ID=34680644

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04807051T ATE446948T1 (de) 2003-12-12 2004-12-08 Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon

Country Status (8)

Country Link
US (1) US7491705B2 (de)
EP (1) EP1692098B1 (de)
KR (1) KR101055236B1 (de)
AT (1) ATE446948T1 (de)
DE (1) DE602004023873D1 (de)
ES (1) ES2331841T3 (de)
PL (1) PL1692098T3 (de)
WO (1) WO2005056519A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009114151A1 (en) * 2008-03-12 2009-09-17 Nektar Therapeutics Oligomer-amino acid and olgomer-atazanavir conjugates
EP2541716A1 (de) 2010-02-25 2013-01-02 Panasonic Corporation Bedarfs- und ausgabesteuerungsvorrichtung, bedarfs- und ausgabesteuerungsverfahren sowie programm dafür
EP2593089B1 (de) * 2010-07-14 2018-04-04 Senju Pharmaceutical Co., Ltd. Feste dispersion eines alfa-ketoamid-derivats
US9539298B2 (en) 2010-11-29 2017-01-10 Osaka City University Lissencephaly therapeutic agent
US9371359B2 (en) 2010-11-29 2016-06-21 Osaka City University Lissencephaly therapeutic agent
EP3127900B1 (de) 2014-03-31 2017-10-18 Senju Pharmaceutical Co., Ltd. Alkynylindazolderivat und verwendung davon
CN107001240B (zh) * 2014-09-08 2019-11-05 兰德施泰纳根梅德公司 二肽基酮酰胺化合物及其用于治疗和/或预防脂肪积累的用途
WO2016077461A2 (en) * 2014-11-11 2016-05-19 Western University Of Health Sciences Isoform-specific calpain inhibitors, methods of identification, and uses thereof
EP3452034B1 (de) 2016-05-06 2024-05-15 Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca Calpain-inhibitoren in der vorbeugung und/oder behandlung von ventrikulärer neumodellierung
EP3466421B1 (de) 2016-05-23 2022-11-30 Osaka City University Zusammensetzung zur behandlung von peripheren nervenerkrankungen
EP3564211A1 (de) * 2018-05-03 2019-11-06 Landsteiner Genmed, S.L. Dipeptidyl ketoamid meta-methoxyphenyl derivate und deren verwendung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
EP0564561A4 (en) 1990-12-28 1994-08-10 Georgia Tech Res Inst Peptides ketoamides, ketoacids, and ketoesters
US5650508A (en) * 1991-12-27 1997-07-22 Georgia Tech Research Corporation Peptide ketoamides
US6235929B1 (en) 1991-12-27 2001-05-22 Georgia Tech Research Corporation Tripeptide α-ketoamides
AU4544993A (en) * 1992-06-24 1994-01-24 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity
US5514694A (en) 1992-09-21 1996-05-07 Georgia Tech Research Corp Peptidyl ketoamides
US5541290A (en) * 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds
JP2825198B2 (ja) * 1995-09-01 1998-11-18 本田技研工業株式会社 車両用無段変速機構の油圧制御装置
US5763576A (en) * 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
US6150378A (en) 1997-10-07 2000-11-21 Cephalon, Inc. Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors
US6686335B1 (en) * 1998-09-22 2004-02-03 Cephalon, Inc. Hydroxamate-containing cysteine and serine protease inhibitors
WO2002078670A1 (en) 2001-03-02 2002-10-10 Neuron Therapeutics, Inc. Neuroprotectants formulations and methods

Also Published As

Publication number Publication date
WO2005056519A1 (en) 2005-06-23
KR20060134929A (ko) 2006-12-28
EP1692098B1 (de) 2009-10-28
PL1692098T3 (pl) 2010-03-31
US20070004643A1 (en) 2007-01-04
EP1692098A1 (de) 2006-08-23
ES2331841T3 (es) 2010-01-18
KR101055236B1 (ko) 2011-08-08
US7491705B2 (en) 2009-02-17
DE602004023873D1 (de) 2009-12-10

Similar Documents

Publication Publication Date Title
EA200601852A1 (ru) Тетрагидрохинолиновые производные и способ их получения
DE60230266D1 (de) Phenylpyridincarbonyl piperazinderivate
NO20081464L (no) 1-heterocyklusulfonyl, 2-aminometyl, 5-(hetero-)aryl subsidiert 1-H-pyrrol-derivater som syresekresjonsinhibitorer
AR057914A1 (es) Compuestos organicos de azufre y su uso
NO20082243L (no) Fremgangsmater og forbindelser for fremstiliing av CC-1065 analoger
NO20033385D0 (no) Fuserte heterocykliske forbindelser
CO5690643A2 (es) Derivados de triaza-espiropiperidina para usarlos como inhibidores de glyt-1 en el tratamiento de desordenes neurologicos y neuropsiquiatricos
CO5640117A2 (es) Derivados de 2,4-diamonopirimidina
NO20071642L (no) N-Benzensulfonylsubstituerte anilino-pyrimidinanaloger
HUP0400326A2 (hu) Orexin receptor antagonistákként alkalmazható ciklikus N-(aril-karbonil)-amin-származékok és ezeket tartalmazó gyógyszerkészítmények
NO20062950L (no) 5,7-diaminopyrazolo `43-Dlpyrimidiner med PDE-5 inhiberende aktivitet
TW200602322A (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
ATE383338T1 (de) N-(phenyl(piperidin-2-yl)methyl)benzamid-deriva e,verfahren zu deren herstellung und ihre therapeutische verwendung
SE0100903D0 (sv) Compounds
WO2008136444A1 (ja) 縮合複素環誘導体
WO2009054439A1 (ja) Pai-1産生抑制剤
ATE446948T1 (de) Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon
NO20075904L (no) Benzimidazolforbindelser
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
EA200401470A1 (ru) Производные пиперазинилацилпиперидина, их получение и их терапевтическое применение
EA201071012A1 (ru) Производные азетидинов, способ их получения и применение их в терапии
NO20061832L (no) Karboksamidderivat av amidtype
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
ATE399168T1 (de) Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
ATE402185T1 (de) Verfahren für fluorcytidinderivate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1692098

Country of ref document: EP