ATE402185T1 - Verfahren für fluorcytidinderivate - Google Patents

Verfahren für fluorcytidinderivate

Info

Publication number
ATE402185T1
ATE402185T1 AT04803900T AT04803900T ATE402185T1 AT E402185 T1 ATE402185 T1 AT E402185T1 AT 04803900 T AT04803900 T AT 04803900T AT 04803900 T AT04803900 T AT 04803900T AT E402185 T1 ATE402185 T1 AT E402185T1
Authority
AT
Austria
Prior art keywords
sup
fluorcytidine
derivatives
deoxy
aralkyl
Prior art date
Application number
AT04803900T
Other languages
English (en)
Inventor
Christopher Roberts
Jim-Wah Wong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE402185T1 publication Critical patent/ATE402185T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT04803900T 2003-12-22 2004-12-15 Verfahren für fluorcytidinderivate ATE402185T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53226603P 2003-12-22 2003-12-22

Publications (1)

Publication Number Publication Date
ATE402185T1 true ATE402185T1 (de) 2008-08-15

Family

ID=34738779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04803900T ATE402185T1 (de) 2003-12-22 2004-12-15 Verfahren für fluorcytidinderivate

Country Status (13)

Country Link
US (1) US7365188B2 (de)
EP (1) EP1706414B1 (de)
JP (2) JP5350591B2 (de)
KR (2) KR100851272B1 (de)
CN (1) CN101128472B (de)
AT (1) ATE402185T1 (de)
CA (1) CA2550299C (de)
DE (1) DE602004015331D1 (de)
DK (1) DK1706414T3 (de)
ES (1) ES2310298T3 (de)
IL (1) IL176075A (de)
TW (1) TWI291962B (de)
WO (1) WO2005063786A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1706414T3 (da) 2003-12-22 2008-10-13 Hoffmann La Roche Fremgangsmåde til fluorcytidinderivater
KR100834711B1 (ko) * 2006-12-21 2008-06-02 광동제약 주식회사 엔-아실-5'-데옥시-5-플루오로시티딘 유도체의 제조 방법
ITMI20070435A1 (it) * 2007-03-05 2008-09-06 Innovate Biotechnology Srl 2',3'-di-o-acil-5-fluoronucleosidi
US20100130734A1 (en) * 2007-04-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Process for preparing capecitabine
WO2008145403A1 (en) * 2007-06-01 2008-12-04 Synthon B.V. Processes related to making capecitabine
DK2300489T3 (en) * 2008-06-06 2016-02-15 Neurmedix Inc PROCESSES FOR PREPARING 17-alkynyl-7-HYDROXY STEROIDS AND RELATED COMPOUNDS
WO2010017374A1 (en) * 2008-08-06 2010-02-11 Sicor Inc. Process for preparing azacytidine intermediate
WO2010061402A2 (en) * 2008-11-25 2010-06-03 Vishwanath Kannan An improved process for the preparation of capecitabine
WO2010065586A2 (en) * 2008-12-02 2010-06-10 Dr. Reddy's Laboratories Ltd. Preparation of capecitabine
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
WO2011067588A1 (en) 2009-12-04 2011-06-09 Generics [Uk] Limited Cyclic sulphinyl esters of cytidine
WO2011104540A1 (en) 2010-02-24 2011-09-01 Generics [Uk] Limited One step process for the preparation of capecitabine
CN103570781B (zh) * 2012-07-02 2016-01-13 国药一心制药有限公司 一种卡培他滨的工业化制备方法
CN103159813A (zh) * 2013-04-02 2013-06-19 武汉邦伦医药科技有限公司 一种卡培他滨制备工艺中的中间体的制备方法
CN103193842A (zh) * 2013-04-23 2013-07-10 济宁高新技术开发区永丰化工厂 卡培他滨的合成方法
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
CN113321693A (zh) * 2021-05-25 2021-08-31 神隆医药（常熟）有限公司 一种适用于工业化生产的卡培他滨中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038396A (ja) 1983-08-10 1985-02-27 Daikin Ind Ltd ５−フルオロシチジン化合物の製法
JPS6038395A (ja) 1983-08-10 1985-02-27 Daikin Ind Ltd ５−フルオロシチジン類の製法
EP0339075B1 (de) * 1987-10-28 1993-08-18 Pro-Neuron, Inc. Acylatiertes uridin und cytidin und deren verwendungen
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (de) * 1992-12-18 1995-08-21 Hoffmann La Roche
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
GB2372742A (en) * 2001-03-03 2002-09-04 Univ Leiden C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses
AU2003297261B2 (en) * 2002-11-07 2008-10-23 Board Of Regents, The University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
DK1706414T3 (da) 2003-12-22 2008-10-13 Hoffmann La Roche Fremgangsmåde til fluorcytidinderivater

Also Published As

Publication number Publication date
WO2005063786A3 (en) 2006-12-14
IL176075A (en) 2011-06-30
TWI291962B (en) 2008-01-01
DK1706414T3 (da) 2008-10-13
EP1706414A2 (de) 2006-10-04
JP5350591B2 (ja) 2013-11-27
EP1706414B1 (de) 2008-07-23
TW200528464A (en) 2005-09-01
ES2310298T3 (es) 2009-01-01
CN101128472B (zh) 2012-03-14
JP2007515440A (ja) 2007-06-14
KR20080046752A (ko) 2008-05-27
IL176075A0 (en) 2006-10-05
CN101128472A (zh) 2008-02-20
CA2550299A1 (en) 2005-07-14
KR100851272B1 (ko) 2008-08-08
WO2005063786A2 (en) 2005-07-14
DE602004015331D1 (de) 2008-09-04
JP2012097095A (ja) 2012-05-24
KR20060107803A (ko) 2006-10-16
US20050137392A1 (en) 2005-06-23
CA2550299C (en) 2010-03-30
US7365188B2 (en) 2008-04-29

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