ATE402185T1 - Verfahren für fluorcytidinderivate - Google Patents
Verfahren für fluorcytidinderivateInfo
- Publication number
- ATE402185T1 ATE402185T1 AT04803900T AT04803900T ATE402185T1 AT E402185 T1 ATE402185 T1 AT E402185T1 AT 04803900 T AT04803900 T AT 04803900T AT 04803900 T AT04803900 T AT 04803900T AT E402185 T1 ATE402185 T1 AT E402185T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- fluorcytidine
- derivatives
- deoxy
- aralkyl
- Prior art date
Links
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53226603P | 2003-12-22 | 2003-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402185T1 true ATE402185T1 (de) | 2008-08-15 |
Family
ID=34738779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04803900T ATE402185T1 (de) | 2003-12-22 | 2004-12-15 | Verfahren für fluorcytidinderivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7365188B2 (de) |
| EP (1) | EP1706414B1 (de) |
| JP (2) | JP5350591B2 (de) |
| KR (2) | KR100851272B1 (de) |
| CN (1) | CN101128472B (de) |
| AT (1) | ATE402185T1 (de) |
| CA (1) | CA2550299C (de) |
| DE (1) | DE602004015331D1 (de) |
| DK (1) | DK1706414T3 (de) |
| ES (1) | ES2310298T3 (de) |
| IL (1) | IL176075A (de) |
| TW (1) | TWI291962B (de) |
| WO (1) | WO2005063786A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1706414T3 (da) | 2003-12-22 | 2008-10-13 | Hoffmann La Roche | Fremgangsmåde til fluorcytidinderivater |
| KR100834711B1 (ko) * | 2006-12-21 | 2008-06-02 | 광동제약 주식회사 | 엔-아실-5'-데옥시-5-플루오로시티딘 유도체의 제조 방법 |
| ITMI20070435A1 (it) * | 2007-03-05 | 2008-09-06 | Innovate Biotechnology Srl | 2',3'-di-o-acil-5-fluoronucleosidi |
| MX2009011255A (es) * | 2007-04-20 | 2009-11-23 | Reddys Lab Ltd Dr | Proceso para preparar capecitabina. |
| WO2008145403A1 (en) * | 2007-06-01 | 2008-12-04 | Synthon B.V. | Processes related to making capecitabine |
| CA2724130C (en) | 2008-06-06 | 2016-04-26 | Harbor Biosciences, Inc. | Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds |
| WO2010017374A1 (en) * | 2008-08-06 | 2010-02-11 | Sicor Inc. | Process for preparing azacytidine intermediate |
| WO2010061402A2 (en) * | 2008-11-25 | 2010-06-03 | Vishwanath Kannan | An improved process for the preparation of capecitabine |
| EP2370414A4 (de) * | 2008-12-02 | 2012-11-14 | Reddys Lab Ltd Dr | Herstellung von capecitabin |
| GB0907551D0 (en) | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| WO2011067588A1 (en) | 2009-12-04 | 2011-06-09 | Generics [Uk] Limited | Cyclic sulphinyl esters of cytidine |
| WO2011104540A1 (en) | 2010-02-24 | 2011-09-01 | Generics [Uk] Limited | One step process for the preparation of capecitabine |
| CN103570781B (zh) * | 2012-07-02 | 2016-01-13 | 国药一心制药有限公司 | 一种卡培他滨的工业化制备方法 |
| CN103159813A (zh) * | 2013-04-02 | 2013-06-19 | 武汉邦伦医药科技有限公司 | 一种卡培他滨制备工艺中的中间体的制备方法 |
| CN103193842A (zh) * | 2013-04-23 | 2013-07-10 | 济宁高新技术开发区永丰化工厂 | 卡培他滨的合成方法 |
| EP3746134A1 (de) | 2018-02-02 | 2020-12-09 | Maverix Oncology, Inc. | Kleinmolekülige wirkstoffkonjugate von gemcitabinmonophosphat |
| CN113321693A (zh) * | 2021-05-25 | 2021-08-31 | 神隆医药（常熟）有限公司 | 一种适用于工业化生产的卡培他滨中间体的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6038395A (ja) | 1983-08-10 | 1985-02-27 | Daikin Ind Ltd | ５−フルオロシチジン類の製法 |
| JPS6038396A (ja) | 1983-08-10 | 1985-02-27 | Daikin Ind Ltd | ５−フルオロシチジン化合物の製法 |
| AU2789989A (en) * | 1987-10-28 | 1989-05-23 | Pro-Neuron, Inc. | Acylated uridine and cytidine and uses thereof |
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| TW254946B (de) | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
| US5476932A (en) * | 1994-08-26 | 1995-12-19 | Hoffmann-La Roche Inc. | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
| GB2372742A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses |
| WO2004044227A2 (en) * | 2002-11-07 | 2004-05-27 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (ec)-drug conjugates, compositions and methods for tissue specific disease imaging |
| DK1706414T3 (da) | 2003-12-22 | 2008-10-13 | Hoffmann La Roche | Fremgangsmåde til fluorcytidinderivater |
-
2004
- 2004-12-15 DK DK04803900T patent/DK1706414T3/da active
- 2004-12-15 KR KR1020067011255A patent/KR100851272B1/ko not_active Expired - Lifetime
- 2004-12-15 ES ES04803900T patent/ES2310298T3/es not_active Expired - Lifetime
- 2004-12-15 KR KR1020087011676A patent/KR20080046752A/ko not_active Ceased
- 2004-12-15 WO PCT/EP2004/014281 patent/WO2005063786A2/en not_active Ceased
- 2004-12-15 JP JP2006545995A patent/JP5350591B2/ja not_active Expired - Lifetime
- 2004-12-15 EP EP04803900A patent/EP1706414B1/de not_active Expired - Lifetime
- 2004-12-15 AT AT04803900T patent/ATE402185T1/de active
- 2004-12-15 DE DE602004015331T patent/DE602004015331D1/de not_active Expired - Lifetime
- 2004-12-15 CA CA2550299A patent/CA2550299C/en not_active Expired - Lifetime
- 2004-12-15 CN CN2004800383465A patent/CN101128472B/zh not_active Expired - Lifetime
- 2004-12-17 TW TW093139468A patent/TWI291962B/zh not_active IP Right Cessation
- 2004-12-22 US US11/021,703 patent/US7365188B2/en not_active Expired - Lifetime
-
2006
- 2006-05-31 IL IL176075A patent/IL176075A/en active IP Right Grant
-
2011
- 2011-12-07 JP JP2011268253A patent/JP2012097095A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080046752A (ko) | 2008-05-27 |
| CA2550299A1 (en) | 2005-07-14 |
| US20050137392A1 (en) | 2005-06-23 |
| IL176075A0 (en) | 2006-10-05 |
| EP1706414B1 (de) | 2008-07-23 |
| TW200528464A (en) | 2005-09-01 |
| IL176075A (en) | 2011-06-30 |
| WO2005063786A2 (en) | 2005-07-14 |
| KR100851272B1 (ko) | 2008-08-08 |
| KR20060107803A (ko) | 2006-10-16 |
| US7365188B2 (en) | 2008-04-29 |
| JP2007515440A (ja) | 2007-06-14 |
| JP5350591B2 (ja) | 2013-11-27 |
| EP1706414A2 (de) | 2006-10-04 |
| JP2012097095A (ja) | 2012-05-24 |
| CA2550299C (en) | 2010-03-30 |
| CN101128472B (zh) | 2012-03-14 |
| WO2005063786A3 (en) | 2006-12-14 |
| CN101128472A (zh) | 2008-02-20 |
| DE602004015331D1 (de) | 2008-09-04 |
| ES2310298T3 (es) | 2009-01-01 |
| DK1706414T3 (da) | 2008-10-13 |
| TWI291962B (en) | 2008-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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