NO20075904L - Benzimidazolforbindelser - Google Patents
BenzimidazolforbindelserInfo
- Publication number
- NO20075904L NO20075904L NO20075904A NO20075904A NO20075904L NO 20075904 L NO20075904 L NO 20075904L NO 20075904 A NO20075904 A NO 20075904A NO 20075904 A NO20075904 A NO 20075904A NO 20075904 L NO20075904 L NO 20075904L
- Authority
- NO
- Norway
- Prior art keywords
- group
- dioxan
- dimethyl
- secretion
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Det beskrives en ny kjemisk forbindelse som benyttes som terapeutisk eller profylaktisk middel for syrerelaterte sykdommer, med en utmerket inhibitorisk effekt mot sekresjon av gastrisk syre, en utmerket effekt mot å opprettholde den inhibitoriske effekt på sekresjon av gastrisk syre for derved å opprettholde en høy intragastrisk pH-verdi over lengre tid. Forbindelsen oppviser høy sikkerhet og en god fysikokjemisk stabilitet. Det beskrives således en forbindelse representert ved formel 1: der R1 og R3 kan være lik eller forskjellig og hver bety et hydrogenatom eller en C1- C6 alkylgruppe; R2 betyr en (5,5-dimetyl-1,3-dioksan-2-yl)metoksygruppe, 5,7-dioksaspiro[2.5]oct-6-ylmetoksygruppe, 1,5,9-trioksaspiro[5.5]undec-3-ylmetoksygruppe, eller (2,2-dimetyl-1,3-dioksan-5-yl)metoksygruppe; R4 , R5 , R6 og R7 er et hydrogenatom, halogenatom, C1-C6 alkylgruppe, C1-C6 haloalkylgruppe, C1-C6 alkoksygruppe eller C1-C6 haloalkoksygruppe; og W1 er en enkeltbinding, metylen- eller etylengruppe; eller et salt derav eller et solvat av disse.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005117643 | 2005-04-15 | ||
US67584805P | 2005-04-29 | 2005-04-29 | |
PCT/JP2006/308069 WO2006112442A1 (ja) | 2005-04-15 | 2006-04-17 | ベンズイミダゾール化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20075904L true NO20075904L (no) | 2007-11-15 |
NO339502B1 NO339502B1 (no) | 2016-12-19 |
Family
ID=37115157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075904A NO339502B1 (no) | 2005-04-15 | 2007-11-15 | Benzimidazolforbindelser |
Country Status (23)
Country | Link |
---|---|
US (3) | US20070015782A1 (no) |
EP (1) | EP1870409B1 (no) |
JP (1) | JP4949246B2 (no) |
KR (1) | KR101285696B1 (no) |
AU (1) | AU2006237974B2 (no) |
BR (1) | BRPI0608400B8 (no) |
CA (1) | CA2602610C (no) |
CY (1) | CY1110074T1 (no) |
DE (1) | DE602006014261D1 (no) |
DK (1) | DK1870409T3 (no) |
ES (1) | ES2344467T3 (no) |
HK (1) | HK1117826A1 (no) |
HR (1) | HRP20100389T1 (no) |
IL (1) | IL186282A (no) |
ME (1) | ME01855B (no) |
NO (1) | NO339502B1 (no) |
NZ (1) | NZ561920A (no) |
PL (1) | PL1870409T3 (no) |
PT (1) | PT1870409E (no) |
RS (1) | RS51389B (no) |
RU (1) | RU2409573C2 (no) |
SI (1) | SI1870409T1 (no) |
WO (1) | WO2006112442A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070015782A1 (en) * | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
WO2007122686A1 (ja) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | ベンズイミダゾール化合物 |
US20110009624A9 (en) * | 2006-10-13 | 2011-01-13 | Masato Ueda | Benzimidazole compounds having gastric acid secretion inhibitory action |
JP2009196894A (ja) * | 2006-10-13 | 2009-09-03 | Eisai R & D Management Co Ltd | スルフィニルベンズイミダゾール化合物またはその塩の製造方法 |
TWI546306B (zh) * | 2007-04-11 | 2016-08-21 | 第一三共股份有限公司 | 神經胺酸衍生物之製造方法 |
ES2381210T3 (es) | 2007-12-18 | 2012-05-24 | Nestec S.A. | Sistema para la preparación de una bebida a partir de ingredientes facilitados por un elemento postizo codificado |
AU2011272853A1 (en) | 2010-07-01 | 2013-01-10 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of PI3K activity |
JP6262733B2 (ja) | 2012-09-04 | 2018-01-17 | シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドShanghai Hengrui Pharmaceutical Co., Ltd. | イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 |
EP2803666B1 (de) * | 2013-05-17 | 2016-04-27 | Symrise AG | Cyclische Acetale und Ketale sowie deren Verwendung als Riechstoff |
JP6377334B2 (ja) * | 2013-10-25 | 2018-08-22 | 東洋鋼鈑株式会社 | 非線形光学色素、フォトリフラクティブ材料組成物、フォトリフラクティブ基材およびホログラム記録媒体 |
WO2016104668A1 (ja) * | 2014-12-26 | 2016-06-30 | 国立大学法人 東京大学 | 光学活性のプロトンポンプ阻害化合物の製造方法 |
US10544113B2 (en) | 2016-03-07 | 2020-01-28 | National Health Research Institute | Thiazolidinone compounds and use thereof |
CN112457175B (zh) * | 2020-11-03 | 2022-09-02 | 山东师范大学 | 一种制备1,3-二苄氧基-2-丙酮的方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
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SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
EP0187977B1 (en) | 1984-12-18 | 1990-08-29 | Otsuka Pharmaceutical Co., Ltd. | Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same |
JPS62277322A (ja) | 1986-02-13 | 1987-12-02 | Takeda Chem Ind Ltd | 安定化された腸溶性抗潰瘍固形組成物 |
JPS62207271A (ja) | 1986-03-06 | 1987-09-11 | Yamanouchi Pharmaceut Co Ltd | 2−ピリジルメチルチオ基または2−ピリジルメチルスルフイニル基で置換された縮合環化合物 |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
JPH0643426B2 (ja) | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
US5026560A (en) | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
JPH0222273A (ja) * | 1987-07-21 | 1990-01-25 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物およびその医薬用途 |
JPH0633261B2 (ja) | 1988-01-22 | 1994-05-02 | 東京田辺製薬株式会社 | 新規なイミダゾ[4,5−bピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
PL166209B1 (pl) | 1990-06-20 | 1995-04-28 | Astra Ab | Sposób wytwarzania nowych pochodnych benzimidazolu PL |
SE9002206D0 (sv) * | 1990-06-20 | 1990-06-20 | Haessle Ab | New compounds |
JP2820829B2 (ja) | 1991-03-07 | 1998-11-05 | 武田薬品工業株式会社 | 有核散剤およびその製造方法 |
JPH05117268A (ja) * | 1991-10-22 | 1993-05-14 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
JPH05177268A (ja) | 1992-01-09 | 1993-07-20 | Amada Co Ltd | 縦型パンチプレス |
CN1148171C (zh) | 1998-04-17 | 2004-05-05 | 大正制药株式会社 | 多单元缓释片剂 |
BR9912937A (pt) | 1998-08-10 | 2001-05-08 | Partnership Of Michael E Garst | Pró-drogas de inibidores de bomba de prótons |
TW404832B (en) | 1999-01-27 | 2000-09-11 | Nang Kuang Pharmaceutical Co L | The oral medicine with good stability cotaining the omeprazole or the analogues |
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
EP1154771A4 (en) | 1999-02-26 | 2005-04-20 | Nitromed Inc | INHIBITORS OF THE PROTON NITROSIS AND NITROSYL PUMP, COMPOSITIONS AND METHODS OF USE |
ES2168043B1 (es) | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
AU2001296908A1 (en) | 2000-09-29 | 2002-04-08 | Geneva Pharmaceuticals, Inc. | Proton pump inhibitor formulation |
CN100562317C (zh) | 2001-10-17 | 2009-11-25 | 武田药品工业株式会社 | 含大量酸不稳定药物的颗粒 |
JP4331930B2 (ja) | 2001-10-17 | 2009-09-16 | 武田薬品工業株式会社 | 酸に不安定な薬物の高含量顆粒 |
JP2003137771A (ja) | 2001-10-30 | 2003-05-14 | Nichiko Pharmaceutical Co Ltd | 難溶性薬物用医薬製剤 |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
US20040166162A1 (en) | 2003-01-24 | 2004-08-26 | Robert Niecestro | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
EP1602362B1 (en) | 2003-03-12 | 2016-09-28 | Takeda Pharmaceutical Company Limited | Drug composition having active ingredient adhered at high concentration to spherical core |
WO2005011637A1 (ja) | 2003-08-04 | 2005-02-10 | Eisai Co., Ltd. | 用時分散型製剤 |
US20070015782A1 (en) * | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
-
2006
- 2006-04-14 US US11/403,815 patent/US20070015782A1/en not_active Abandoned
- 2006-04-17 ME MEP-2010-346A patent/ME01855B/me unknown
- 2006-04-17 EP EP06731998A patent/EP1870409B1/en active Active
- 2006-04-17 JP JP2007528143A patent/JP4949246B2/ja active Active
- 2006-04-17 BR BRPI0608400A patent/BRPI0608400B8/pt active IP Right Grant
- 2006-04-17 DE DE602006014261T patent/DE602006014261D1/de active Active
- 2006-04-17 ES ES06731998T patent/ES2344467T3/es active Active
- 2006-04-17 RU RU2007138053/04A patent/RU2409573C2/ru active
- 2006-04-17 RS RSP-2010/0346A patent/RS51389B/en unknown
- 2006-04-17 AU AU2006237974A patent/AU2006237974B2/en active Active
- 2006-04-17 NZ NZ561920A patent/NZ561920A/en not_active IP Right Cessation
- 2006-04-17 KR KR1020077023561A patent/KR101285696B1/ko active IP Right Grant
- 2006-04-17 DK DK06731998.8T patent/DK1870409T3/da active
- 2006-04-17 SI SI200630712T patent/SI1870409T1/sl unknown
- 2006-04-17 WO PCT/JP2006/308069 patent/WO2006112442A1/ja active Application Filing
- 2006-04-17 PT PT06731998T patent/PT1870409E/pt unknown
- 2006-04-17 CA CA2602610A patent/CA2602610C/en active Active
- 2006-04-17 PL PL06731998T patent/PL1870409T3/pl unknown
- 2006-09-14 US US11/520,838 patent/US7425634B2/en active Active
-
2007
- 2007-09-25 IL IL186282A patent/IL186282A/en active IP Right Grant
- 2007-11-15 NO NO20075904A patent/NO339502B1/no not_active IP Right Cessation
-
2008
- 2008-07-17 HK HK08107942.6A patent/HK1117826A1/xx not_active IP Right Cessation
- 2008-08-11 US US12/189,590 patent/US8124780B2/en not_active Expired - Fee Related
-
2010
- 2010-06-11 CY CY20101100543T patent/CY1110074T1/el unknown
- 2010-07-15 HR HR20100389T patent/HRP20100389T1/hr unknown
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