NO20075904L - Benzimidazolforbindelser - Google Patents

Benzimidazolforbindelser

Info

Publication number
NO20075904L
NO20075904L NO20075904A NO20075904A NO20075904L NO 20075904 L NO20075904 L NO 20075904L NO 20075904 A NO20075904 A NO 20075904A NO 20075904 A NO20075904 A NO 20075904A NO 20075904 L NO20075904 L NO 20075904L
Authority
NO
Norway
Prior art keywords
group
dioxan
dimethyl
secretion
hydrogen atom
Prior art date
Application number
NO20075904A
Other languages
English (en)
Other versions
NO339502B1 (no
Inventor
Tetsuya Kawahara
Shuhei Miyazawa
Hitoshi Harada
Hideaki Fujisaki
Atsuhiko Kubota
Junichi Nagakawa
Nobuhisa Watanabe
Masanobu Shinoda
Daisuke Iida
Hiroki Terauchi
Masato Ueda
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of NO20075904L publication Critical patent/NO20075904L/no
Publication of NO339502B1 publication Critical patent/NO339502B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det beskrives en ny kjemisk forbindelse som benyttes som terapeutisk eller profylaktisk middel for syrerelaterte sykdommer, med en utmerket inhibitorisk effekt mot sekresjon av gastrisk syre, en utmerket effekt mot å opprettholde den inhibitoriske effekt på sekresjon av gastrisk syre for derved å opprettholde en høy intragastrisk pH-verdi over lengre tid. Forbindelsen oppviser høy sikkerhet og en god fysikokjemisk stabilitet. Det beskrives således en forbindelse representert ved formel 1: der R1 og R3 kan være lik eller forskjellig og hver bety et hydrogenatom eller en C1- C6 alkylgruppe; R2 betyr en (5,5-dimetyl-1,3-dioksan-2-yl)metoksygruppe, 5,7-dioksaspiro[2.5]oct-6-ylmetoksygruppe, 1,5,9-trioksaspiro[5.5]undec-3-ylmetoksygruppe, eller (2,2-dimetyl-1,3-dioksan-5-yl)metoksygruppe; R4 , R5 , R6 og R7 er et hydrogenatom, halogenatom, C1-C6 alkylgruppe, C1-C6 haloalkylgruppe, C1-C6 alkoksygruppe eller C1-C6 haloalkoksygruppe; og W1 er en enkeltbinding, metylen- eller etylengruppe; eller et salt derav eller et solvat av disse.
NO20075904A 2005-04-15 2007-11-15 Benzimidazolforbindelser NO339502B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005117643 2005-04-15
US67584805P 2005-04-29 2005-04-29
PCT/JP2006/308069 WO2006112442A1 (ja) 2005-04-15 2006-04-17 ベンズイミダゾール化合物

Publications (2)

Publication Number Publication Date
NO20075904L true NO20075904L (no) 2007-11-15
NO339502B1 NO339502B1 (no) 2016-12-19

Family

ID=37115157

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075904A NO339502B1 (no) 2005-04-15 2007-11-15 Benzimidazolforbindelser

Country Status (23)

Country Link
US (3) US20070015782A1 (no)
EP (1) EP1870409B1 (no)
JP (1) JP4949246B2 (no)
KR (1) KR101285696B1 (no)
AU (1) AU2006237974B2 (no)
BR (1) BRPI0608400B8 (no)
CA (1) CA2602610C (no)
CY (1) CY1110074T1 (no)
DE (1) DE602006014261D1 (no)
DK (1) DK1870409T3 (no)
ES (1) ES2344467T3 (no)
HK (1) HK1117826A1 (no)
HR (1) HRP20100389T1 (no)
IL (1) IL186282A (no)
ME (1) ME01855B (no)
NO (1) NO339502B1 (no)
NZ (1) NZ561920A (no)
PL (1) PL1870409T3 (no)
PT (1) PT1870409E (no)
RS (1) RS51389B (no)
RU (1) RU2409573C2 (no)
SI (1) SI1870409T1 (no)
WO (1) WO2006112442A1 (no)

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WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
EP2065379A4 (en) * 2006-10-13 2011-01-19 Eisai R&D Man Co Ltd BENZIMIDAZOLE HAVING INHIBITORY ACTIVITY OF GASTRIC ACID SECRETION
JP2009196894A (ja) * 2006-10-13 2009-09-03 Eisai R & D Management Co Ltd スルフィニルベンズイミダゾール化合物またはその塩の製造方法
TWI460182B (zh) * 2007-04-11 2014-11-11 Daiichi Sankyo Co Ltd 原酸酯之製造方法
PL2071986T3 (pl) 2007-12-18 2012-07-31 Nestec Sa System do wytwarzania napoju ze składników podtrzymywanych przez zakodowaną wkładkę
AU2011272853A1 (en) 2010-07-01 2013-01-10 Amgen Inc. Heterocyclic compounds and their use as inhibitors of PI3K activity
CN103958480B (zh) 2012-09-04 2016-04-06 上海恒瑞医药有限公司 咪唑啉类衍生物、其制备方法及其在医药上的应用
EP2803666B1 (de) * 2013-05-17 2016-04-27 Symrise AG Cyclische Acetale und Ketale sowie deren Verwendung als Riechstoff
JP6377334B2 (ja) * 2013-10-25 2018-08-22 東洋鋼鈑株式会社 非線形光学色素、フォトリフラクティブ材料組成物、フォトリフラクティブ基材およびホログラム記録媒体
EP3239146A4 (en) 2014-12-26 2018-05-30 The University of Tokyo Method for producing proton pump inhibitor compound having optical activity
US10544113B2 (en) 2016-03-07 2020-01-28 National Health Research Institute Thiazolidinone compounds and use thereof
CN112457175B (zh) * 2020-11-03 2022-09-02 山东师范大学 一种制备1,3-二苄氧基-2-丙酮的方法

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Also Published As

Publication number Publication date
PL1870409T3 (pl) 2010-10-29
NZ561920A (en) 2010-01-29
BRPI0608400A2 (pt) 2010-11-16
IL186282A0 (en) 2008-01-20
ME01855B (me) 2011-02-28
JP4949246B2 (ja) 2012-06-06
EP1870409A4 (en) 2009-09-23
PT1870409E (pt) 2010-06-22
US20070010542A1 (en) 2007-01-11
ES2344467T3 (es) 2010-08-27
BRPI0608400B8 (pt) 2021-05-25
RU2007138053A (ru) 2009-05-20
IL186282A (en) 2014-05-28
RS51389B (en) 2011-02-28
JPWO2006112442A1 (ja) 2008-12-11
CY1110074T1 (el) 2015-01-14
CA2602610A1 (en) 2006-10-26
NO339502B1 (no) 2016-12-19
WO2006112442A1 (ja) 2006-10-26
DE602006014261D1 (en) 2010-06-24
US20090203911A1 (en) 2009-08-13
US7425634B2 (en) 2008-09-16
US8124780B2 (en) 2012-02-28
HRP20100389T1 (hr) 2010-08-31
HK1117826A1 (en) 2009-01-23
RU2409573C2 (ru) 2011-01-20
US20070015782A1 (en) 2007-01-18
AU2006237974A1 (en) 2006-10-26
EP1870409B1 (en) 2010-05-12
KR20070120531A (ko) 2007-12-24
KR101285696B1 (ko) 2013-07-12
CA2602610C (en) 2013-01-22
DK1870409T3 (da) 2010-08-09
SI1870409T1 (sl) 2010-08-31
AU2006237974B2 (en) 2011-07-07
EP1870409A1 (en) 2007-12-26
BRPI0608400B1 (pt) 2020-05-05

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