FR2864536B1 - Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre - Google Patents

Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre

Info

Publication number
FR2864536B1
FR2864536B1 FR0315398A FR0315398A FR2864536B1 FR 2864536 B1 FR2864536 B1 FR 2864536B1 FR 0315398 A FR0315398 A FR 0315398A FR 0315398 A FR0315398 A FR 0315398A FR 2864536 B1 FR2864536 B1 FR 2864536B1
Authority
FR
France
Prior art keywords
benzofuranes
intermediates
benzoyl
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0315398A
Other languages
English (en)
Other versions
FR2864536A1 (fr
Inventor
Alain Schouteeten
Francois Bleger
Francoise Mordacq
Jerome Piron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clariant France SA
Original Assignee
Clariant France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0315398A priority Critical patent/FR2864536B1/fr
Application filed by Clariant France SA filed Critical Clariant France SA
Priority to US10/584,440 priority patent/US7544817B2/en
Priority to EP12003772A priority patent/EP2508517A1/fr
Priority to DK04801395.7T priority patent/DK1699772T3/da
Priority to KR1020067012489A priority patent/KR101150627B1/ko
Priority to ES04801395T priority patent/ES2400943T3/es
Priority to EP04801395A priority patent/EP1699772B1/fr
Priority to PCT/IB2004/004158 priority patent/WO2005066149A1/fr
Priority to JP2006546365A priority patent/JP4896735B2/ja
Priority to CN200910006741XA priority patent/CN101486698B/zh
Priority to CNB2004800382852A priority patent/CN100475801C/zh
Priority to TW093140136A priority patent/TWI365878B/zh
Publication of FR2864536A1 publication Critical patent/FR2864536A1/fr
Application granted granted Critical
Publication of FR2864536B1 publication Critical patent/FR2864536B1/fr
Priority to NO20062936A priority patent/NO20062936L/no
Priority to HK07104023.6A priority patent/HK1097835A1/xx
Priority to JP2011175599A priority patent/JP5400840B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0315398A 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre Expired - Fee Related FR2864536B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR0315398A FR2864536B1 (fr) 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
CNB2004800382852A CN100475801C (zh) 2003-12-24 2004-12-15 制备2-正烷基-3-(4-羟基苯甲酰基)苯并呋喃及其中间体的方法
DK04801395.7T DK1699772T3 (da) 2003-12-24 2004-12-15 Fremgangsmåde til fremstilling af 2-(n-alkyl)-3-(4-hydroxybenzoyl)benzofuraner samt mellemprodukter dertil
KR1020067012489A KR101150627B1 (ko) 2003-12-24 2004-12-15 N-알킬-2(하이드록시-4 벤조일)-3 벤조퓨란의 제조 방법및 이의 중간 생성물
ES04801395T ES2400943T3 (es) 2003-12-24 2004-12-15 Proceso para la preparación de N-alquil-2(hidroxi-4-benzoil)-3-benzofuranos y compuestos intermedios de los mismos
EP04801395A EP1699772B1 (fr) 2003-12-24 2004-12-15 Procede d'elaboration de n-alkyle-2(hydroxy-4 benzoyle)-3 benzofuranes, et intermediaires correspondants
PCT/IB2004/004158 WO2005066149A1 (fr) 2003-12-24 2004-12-15 Procede d'elaboration de n-alkyle-2(hydroxy-4 benzoyle)-3 benzofuranes, et intermediaires correspondants
JP2006546365A JP4896735B2 (ja) 2003-12-24 2004-12-15 N−アルキル−2(ヒドロキシ−4ベンゾイル)−3ベンゾフラン及びその中間体の調製方法
US10/584,440 US7544817B2 (en) 2003-12-24 2004-12-15 Process for the preparation of n-alkyl-2(hydroxy-4benzoyl)-3 benzofurans and intermediates thereof
EP12003772A EP2508517A1 (fr) 2003-12-24 2004-12-15 Procédé pour la préparation de N-alkyl-2(hydroxy-4 benzoyl)-3 benzofuranes et ses intermédiaires
CN200910006741XA CN101486698B (zh) 2003-12-24 2004-12-15 取代的苯并呋喃及其制备方法
TW093140136A TWI365878B (en) 2003-12-24 2004-12-22 Process for the preparation of 2-(n-alkyl)-3(4-hydroxybenzoyl) benzofurans and its intermediates thereof
NO20062936A NO20062936L (no) 2003-12-24 2006-06-23 Fremgangsmate for fremstilling av N-alkyl-2(hydroksy-4-benzoyl)-3-benzofuraner og dets mellomprodukter derav
HK07104023.6A HK1097835A1 (en) 2003-12-24 2007-04-17 Process for the preparation of 2-(n-alkyl)-3-(4-hydroxybenzoyl) benzofuran and its intermediates
JP2011175599A JP5400840B2 (ja) 2003-12-24 2011-08-11 N−アルキル−2(ヒドロキシ−4ベンゾイル)−3ベンゾフラン及びその中間体の調製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0315398A FR2864536B1 (fr) 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre

Publications (2)

Publication Number Publication Date
FR2864536A1 FR2864536A1 (fr) 2005-07-01
FR2864536B1 true FR2864536B1 (fr) 2006-03-17

Family

ID=34639607

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0315398A Expired - Fee Related FR2864536B1 (fr) 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre

Country Status (12)

Country Link
US (1) US7544817B2 (fr)
EP (2) EP2508517A1 (fr)
JP (2) JP4896735B2 (fr)
KR (1) KR101150627B1 (fr)
CN (2) CN100475801C (fr)
DK (1) DK1699772T3 (fr)
ES (1) ES2400943T3 (fr)
FR (1) FR2864536B1 (fr)
HK (1) HK1097835A1 (fr)
NO (1) NO20062936L (fr)
TW (1) TWI365878B (fr)
WO (1) WO2005066149A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
CN102065855A (zh) 2008-04-17 2011-05-18 赛诺菲-安万特 决奈达隆在制备用于预防因心血管疾病住院或死亡的药物中的用途
EP2246341A1 (fr) 2009-01-23 2010-11-03 Lonza Ltd. Processus de préparation de 2-Alkyl-3-aroyl-5-nitro-benzofuranes
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
EP2452938A1 (fr) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Procédé pour la préparation de dérivés de 3-aroyl-5-aminobenzofurane
FR2973027A1 (fr) * 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
CN103265513A (zh) * 2013-03-25 2013-08-28 德州学院 制备2-烷基-3-(4-羟基苯甲酰基)苯并呋喃的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382742A (en) * 1972-09-19 1975-02-05 Labaz Benzofuran derivatives and process for preparing the same
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
FR2653431B1 (fr) * 1989-10-23 1994-05-27 Sanofi Sa Procede de preparation de derives de benzoyl-3 benzofuranne.
JP2873599B2 (ja) * 1990-03-09 1999-03-24 寿製薬株式会社 新規ベンゾフラン誘導体、尿酸排泄剤及びその製法
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JPH06184132A (ja) * 1992-12-22 1994-07-05 Kotobuki Seiyaku Kk ベンゾフラン誘導体及びその製造方法並びに尿酸排泄剤
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
WO1999058519A1 (fr) * 1998-05-12 1999-11-18 American Home Products Corporation Acides phenyl-oxo-acetiques utiles dans le traitement de l'insulinoresistance et de l'hyperglycemie
FR2803846B1 (fr) 2000-01-17 2002-04-05 Clariant France Sa 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation

Also Published As

Publication number Publication date
JP2007517012A (ja) 2007-06-28
EP2508517A1 (fr) 2012-10-10
JP2012012400A (ja) 2012-01-19
FR2864536A1 (fr) 2005-07-01
ES2400943T3 (es) 2013-04-15
TWI365878B (en) 2012-06-11
EP1699772A1 (fr) 2006-09-13
DK1699772T3 (da) 2013-05-27
CN101486698B (zh) 2011-07-27
CN101486698A (zh) 2009-07-22
JP5400840B2 (ja) 2014-01-29
CN1898226A (zh) 2007-01-17
JP4896735B2 (ja) 2012-03-14
WO2005066149A1 (fr) 2005-07-21
KR101150627B1 (ko) 2012-06-01
NO20062936L (no) 2006-09-22
US20070155831A1 (en) 2007-07-05
HK1097835A1 (en) 2007-07-06
KR20060111608A (ko) 2006-10-27
TW200526616A (en) 2005-08-16
CN100475801C (zh) 2009-04-08
US7544817B2 (en) 2009-06-09
EP1699772B1 (fr) 2013-02-20

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Effective date: 20150831