DK1989200T3 - [4-(benzo[B]thiophen-2-YL)-pyrimidin-2-YL]-aminderivater som IKK-beta-inhibitorer til behandling af cancer og inflammatoriske sygdomme - Google Patents

[4-(benzo[B]thiophen-2-YL)-pyrimidin-2-YL]-aminderivater som IKK-beta-inhibitorer til behandling af cancer og inflammatoriske sygdomme

Info

Publication number
DK1989200T3
DK1989200T3 DK06850430T DK06850430T DK1989200T3 DK 1989200 T3 DK1989200 T3 DK 1989200T3 DK 06850430 T DK06850430 T DK 06850430T DK 06850430 T DK06850430 T DK 06850430T DK 1989200 T3 DK1989200 T3 DK 1989200T3
Authority
DK
Denmark
Prior art keywords
ikk
thiophen
pyrimidin
benzo
cancer
Prior art date
Application number
DK06850430T
Other languages
English (en)
Inventor
Karl Robert Dahnke
Ho-Shen Lin
Chuan Shih
Q May Wang
Bo Zhang
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1989200T3 publication Critical patent/DK1989200T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK06850430T 2005-11-18 2006-11-15 [4-(benzo[B]thiophen-2-YL)-pyrimidin-2-YL]-aminderivater som IKK-beta-inhibitorer til behandling af cancer og inflammatoriske sygdomme DK1989200T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18
PCT/US2006/060911 WO2007092095A2 (en) 2005-11-18 2006-11-15 [4-(benzo [b] thi0phen-2-yl) pyrimidin-2yl] -amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases.

Publications (1)

Publication Number Publication Date
DK1989200T3 true DK1989200T3 (da) 2009-11-09

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06850430T DK1989200T3 (da) 2005-11-18 2006-11-15 [4-(benzo[B]thiophen-2-YL)-pyrimidin-2-YL]-aminderivater som IKK-beta-inhibitorer til behandling af cancer og inflammatoriske sygdomme

Country Status (27)

Country Link
US (1) US7547691B2 (da)
EP (1) EP1989200B1 (da)
JP (1) JP2009516697A (da)
KR (1) KR100990771B1 (da)
CN (1) CN101309918B (da)
AR (1) AR057911A1 (da)
AT (1) ATE437873T1 (da)
AU (1) AU2006337626B2 (da)
BR (1) BRPI0618245A2 (da)
CA (1) CA2629336A1 (da)
CR (1) CR9947A (da)
DE (1) DE602006008187D1 (da)
DK (1) DK1989200T3 (da)
EA (1) EA014426B1 (da)
EC (1) ECSP088456A (da)
ES (1) ES2329085T3 (da)
IL (1) IL190489A0 (da)
MA (1) MA30053B1 (da)
NO (1) NO20082594L (da)
PE (1) PE20070833A1 (da)
PL (1) PL1989200T3 (da)
PT (1) PT1989200E (da)
SI (1) SI1989200T1 (da)
TN (1) TNSN08227A1 (da)
TW (1) TW200800201A (da)
WO (1) WO2007092095A2 (da)
ZA (1) ZA200803940B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101054325B1 (ko) 2006-03-31 2011-08-04 얀센 파마슈티카 엔.브이. 히스타민 ｈ４ 수용체 조절제로서의 벤조이미다졸―２―일 피리미딘 및 피라진
AU2007275221A1 (en) * 2006-07-20 2008-01-24 Allen J. Borchardt Benzothiophene inhibitors of RHO kinase
CN101563342B (zh) 2006-12-21 2012-09-05 伊莱利利公司 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物
CN101568539B (zh) * 2006-12-21 2012-04-25 伊莱利利公司 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物
TW200902012A (en) 2007-05-16 2009-01-16 Lilly Co Eli Triazolyl aminopyrimidine compounds
KR101131261B1 (ko) 2007-05-16 2012-04-24 일라이 릴리 앤드 캄파니 트리아졸릴 아미노피리미딘 화합물
NZ590170A (en) 2008-06-30 2012-04-27 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
US20130035326A1 (en) 2009-08-19 2013-02-07 Ambit Biosciences Corporation Biaryl compounds and methods of use thereof
KR20130069641A (ko) 2010-04-27 2013-06-26 허치슨 메디파르마 리미티드 피리미디닐 인돌 화합물
WO2013058824A1 (en) 2011-04-07 2013-04-25 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
CA3132120C (en) 2012-02-08 2023-10-24 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
WO2017076888A1 (en) * 2015-11-03 2017-05-11 Janssen Pharmaceutica Nv 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
MX2019000980A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
WO2018023070A1 (en) 2016-07-29 2018-02-01 Sunovion Pharmaceuticals, Inc. Compounds and compositions and uses thereof
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573964A1 (en) * 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
EP3630747A1 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Quinazoline derivatives as modulators of mutant kras, hras or nras
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. ISOCHROMAN COMPOUNDS AND USES THEREOF
JP2022525169A (ja) 2019-03-14 2022-05-11 サノビオン ファーマシューティカルズ インク イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3752589A (en) * 1988-05-16 1989-12-12 Georgia State University Research Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
JP4932735B2 (ja) * 2004-12-17 2012-05-16 アムジエン・インコーポレーテツド アミノピリミジン化合物および使用方法

Also Published As

Publication number Publication date
AU2006337626B2 (en) 2012-03-22
AU2006337626A8 (en) 2008-06-19
PT1989200E (pt) 2009-10-12
EP1989200A2 (en) 2008-11-12
EA014426B1 (ru) 2010-12-30
CN101309918B (zh) 2010-12-29
ES2329085T3 (es) 2009-11-20
TW200800201A (en) 2008-01-01
KR20080059451A (ko) 2008-06-27
DE602006008187D1 (de) 2009-09-10
EA200801362A1 (ru) 2009-02-27
ECSP088456A (es) 2008-06-30
US7547691B2 (en) 2009-06-16
NO20082594L (no) 2008-06-10
MA30053B1 (fr) 2008-12-01
CN101309918A (zh) 2008-11-19
IL190489A0 (en) 2008-11-03
WO2007092095A3 (en) 2007-11-08
SI1989200T1 (sl) 2009-12-31
EP1989200B1 (en) 2009-07-29
TNSN08227A1 (en) 2009-10-30
PL1989200T3 (pl) 2009-12-31
ZA200803940B (en) 2009-09-30
BRPI0618245A2 (pt) 2011-08-23
US20080306082A1 (en) 2008-12-11
JP2009516697A (ja) 2009-04-23
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (en) 2007-08-16
PE20070833A1 (es) 2007-08-27
WO2007092095A2 (en) 2007-08-16
CR9947A (es) 2008-11-28
KR100990771B1 (ko) 2010-10-29
ATE437873T1 (de) 2009-08-15
AR057911A1 (es) 2007-12-26

Similar Documents

Publication Publication Date Title
DK1989200T3 (da) [4-(benzo[B]thiophen-2-YL)-pyrimidin-2-YL]-aminderivater som IKK-beta-inhibitorer til behandling af cancer og inflammatoriske sygdomme
CY2022001I1 (el) Παραγωγα του uk-2a
DE602005025733D1 (de) Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase
DK3456707T3 (da) 4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme
ATE520671T1 (de) Pyrimidin-harnstoff-derivate als kinase-hemmer
ATE509011T1 (de) Pyrimidinderivate als 11beta-hsd1-inhibitoren
DK1945631T3 (da) 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer
DK1633726T3 (da) Pyrimidinderivater, der er egnede til behandling af CRTH2-formidlede sygdomme
NO20091423L (no) Pyrimidinderivater og deres anvendelse som kinaseinhibitorer
DE602006008945D1 (de) Isochinolinderivate als inhibitoren von rho-kinase
AP2007004004A0 (en) Pyrrolidyl derivatives of heteroaromatic compoundsas phosphodiesterase inhibitors
SMP200800048B (it) Derivati pirimidinici utilizzati come inibitori dip13-chinasi
CR10369A (es) Pyrimidine derivatives as pi3k inhibitors
ATE400271T1 (de) Aryl-pyridinderivate als 11-beta-hsd1-hemmer
ATE420076T1 (de) Indozolonderivate als 11b-hsd1-inhibitoren
ATE520672T1 (de) Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine
DK1802579T3 (da) Derivater af 3-arylaminopyridin
ATE501138T1 (de) Thiophenderivate als chk-1-inhibitoren
NO20082514L (no) Aminopyrimidiner anvendelige som kinaseinhibitorer
DK2426106T3 (da) Piperidin- og piperazinderivat til behandling af tumorer
DK1979326T3 (da) Pyridin- og pyrimidinderivater som inhibitorer af histondeacetylase
ATE512960T1 (de) Pyrimidinderivate
ATE449080T1 (de) 4-phenyl-6-substituierte pyrimidin-2- carbonitrilderivate
ATE487718T1 (de) Substituierte bizyklische pyrimidonderivate
DK1869020T3 (da) Heteroarylureaderivater egnet til inhibering af CHK1