ATE520672T1 - Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine - Google Patents
Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidineInfo
- Publication number
- ATE520672T1 ATE520672T1 AT05803358T AT05803358T ATE520672T1 AT E520672 T1 ATE520672 T1 AT E520672T1 AT 05803358 T AT05803358 T AT 05803358T AT 05803358 T AT05803358 T AT 05803358T AT E520672 T1 ATE520672 T1 AT E520672T1
- Authority
- AT
- Austria
- Prior art keywords
- carbo
- hiv
- inhibiting
- substituted pyrimidines
- heterocyclic substituted
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104814 | 2004-09-30 | ||
| PCT/EP2005/054931 WO2006035068A2 (en) | 2004-09-30 | 2005-09-29 | Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520672T1 true ATE520672T1 (de) | 2011-09-15 |
Family
ID=34929640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05803358T ATE520672T1 (de) | 2004-09-30 | 2005-09-29 | Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7531548B2 (de) |
| EP (1) | EP1797048B1 (de) |
| JP (1) | JP5162245B2 (de) |
| KR (1) | KR20070057798A (de) |
| CN (1) | CN101031550B (de) |
| AR (1) | AR050970A1 (de) |
| AT (1) | ATE520672T1 (de) |
| AU (1) | AU2005288865B2 (de) |
| BR (1) | BRPI0515935B8 (de) |
| CA (1) | CA2573976C (de) |
| ES (1) | ES2371924T3 (de) |
| IL (1) | IL180760A (de) |
| MX (1) | MX2007003798A (de) |
| RU (1) | RU2403244C2 (de) |
| TW (1) | TW200626560A (de) |
| WO (1) | WO2006035068A2 (de) |
| ZA (1) | ZA200702655B (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102358738A (zh) | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| RU2410379C2 (ru) * | 2004-09-30 | 2011-01-27 | Тиботек Фармасьютикалз Лтд. | 5-замещенные пиримидины, ингибирующие вич |
| CA2577467C (en) * | 2004-09-30 | 2013-05-28 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-heterocyclyl pyrimidines |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP1904457B1 (de) | 2005-06-08 | 2017-09-06 | Rigel Pharmaceuticals, Inc. | Zusammensetzungen und verfahren zur inhibierung des jak-pfades |
| CA2645959C (en) * | 2006-03-30 | 2016-05-17 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines |
| EP2004632B1 (de) | 2006-03-30 | 2014-03-12 | Janssen R&D Ireland | Hiv-inhibierende 5-amido-substituierte pyrimidine |
| MX2009005881A (es) | 2006-12-13 | 2009-06-12 | Hoffmann La Roche | Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. |
| CN106045965A (zh) * | 2006-12-29 | 2016-10-26 | 爱尔兰詹森科学公司 | 抑制hiv的5,6‑取代的嘧啶类化合物 |
| US9006243B2 (en) * | 2006-12-29 | 2015-04-14 | Janssen R&D Ireland | HIV inhibiting 6-substituted pyrimidines |
| US7834024B2 (en) | 2007-03-26 | 2010-11-16 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| NZ603525A (en) | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| AR074210A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina como inhibidores de ptk2-quinasa |
| JP5918693B2 (ja) | 2009-05-05 | 2016-05-18 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | Ｅｇｆｒ阻害剤及び疾患の治療方法 |
| CN105566229A (zh) | 2010-08-10 | 2016-05-11 | 西建阿维拉米斯研究公司 | Btk抑制剂的苯磺酸盐及其用途和制备方法 |
| US9238629B2 (en) | 2010-11-01 | 2016-01-19 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| SG10201508958WA (en) | 2010-11-01 | 2015-11-27 | Celgene Avilomics Res Inc | Heterocyclic Compounds And Uses Thereof |
| EP2637502B1 (de) | 2010-11-10 | 2018-01-10 | Celgene CAR LLC | Mutanten-selektive egfr-hemmer und verwendungen davon |
| JP2014532658A (ja) | 2011-10-28 | 2014-12-08 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | ブルトン型チロシンキナーゼ疾患または障害を治療する方法 |
| JP6317319B2 (ja) | 2012-03-15 | 2018-04-25 | セルジーン シーエーアール エルエルシー | 上皮成長因子受容体キナーゼ阻害剤の固体形態 |
| CA2866857C (en) | 2012-03-15 | 2021-03-09 | Celgene Avilomics Research, Inc. | Salts of an epidermal growth factor receptor kinase inhibitor |
| EP2935226A4 (de) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | Heteroarylverbindungen und verwendungen davon |
| US9561228B2 (en) | 2013-02-08 | 2017-02-07 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US10005760B2 (en) | 2014-08-13 | 2018-06-26 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
| EP4107156A1 (de) | 2020-02-19 | 2022-12-28 | Joint Stock Company "Pharmasyntez" | Bizyklen auf pyrimidinbasis als antivirale mittel zur behandlung und prävention von hiv-infektionen |
| WO2022013684A1 (en) | 2020-07-11 | 2022-01-20 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| KR102939283B1 (ko) * | 2022-05-03 | 2026-03-13 | 한국화학연구원 | 5-클로로-2,4-다이아미노피리미딘을 포함하는 키나아제 억제 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| WO2024103400A1 (zh) * | 2022-11-18 | 2024-05-23 | 水木未来(北京)科技有限公司 | 作为gpr75激活剂的多环化合物、包含其的药物组合物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| ES2361146T3 (es) * | 1998-03-27 | 2011-06-14 | Janssen Pharmaceutica Nv | Derivados de la piramidina inhibitatoria de vih. |
| AU751573C (en) * | 1998-03-27 | 2003-10-09 | Janssen Pharmaceutica N.V. | HIV inhibiting pyrimidine derivatives |
| EP0945447A1 (de) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| JP3635238B2 (ja) * | 1998-11-10 | 2005-04-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖの複製を阻害するピリミジン類 |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| US7276510B2 (en) * | 2000-05-08 | 2007-10-02 | Janssen Pharmaceutica, Inc. | HIV replication inhibitors |
| EP1345925B1 (de) | 2000-12-21 | 2006-05-17 | Vertex Pharmaceuticals Incorporated | Pyrazolverbindungen als proteinkinasehemmer |
| JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| KR20050084027A (ko) * | 2002-11-28 | 2005-08-26 | 쉐링 악티엔게젤샤프트 | Ｃｈｋ-, ｐｄｋ- 및 ａｋｔ-억제성 피리미딘, 그의제조방법 및 약제로서의 그의 용도 |
-
2005
- 2005-09-29 US US11/576,068 patent/US7531548B2/en not_active Expired - Lifetime
- 2005-09-29 JP JP2007534027A patent/JP5162245B2/ja not_active Expired - Fee Related
- 2005-09-29 AT AT05803358T patent/ATE520672T1/de not_active IP Right Cessation
- 2005-09-29 MX MX2007003798A patent/MX2007003798A/es active IP Right Grant
- 2005-09-29 CA CA2573976A patent/CA2573976C/en not_active Expired - Fee Related
- 2005-09-29 TW TW094134106A patent/TW200626560A/zh unknown
- 2005-09-29 WO PCT/EP2005/054931 patent/WO2006035068A2/en not_active Ceased
- 2005-09-29 CN CN200580033118.3A patent/CN101031550B/zh not_active Expired - Fee Related
- 2005-09-29 AU AU2005288865A patent/AU2005288865B2/en not_active Ceased
- 2005-09-29 RU RU2007116161/04A patent/RU2403244C2/ru active
- 2005-09-29 BR BRPI0515935A patent/BRPI0515935B8/pt not_active IP Right Cessation
- 2005-09-29 EP EP05803358A patent/EP1797048B1/de not_active Expired - Lifetime
- 2005-09-29 ES ES05803358T patent/ES2371924T3/es active Active
- 2005-09-29 KR KR1020077003634A patent/KR20070057798A/ko not_active Ceased
- 2005-09-30 AR ARP050104154A patent/AR050970A1/es not_active Application Discontinuation
-
2007
- 2007-01-17 IL IL180760A patent/IL180760A/en active IP Right Grant
- 2007-03-29 ZA ZA200702655A patent/ZA200702655B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0515935B8 (pt) | 2021-05-25 |
| IL180760A0 (en) | 2007-06-03 |
| US7531548B2 (en) | 2009-05-12 |
| JP2008514680A (ja) | 2008-05-08 |
| CN101031550B (zh) | 2015-05-27 |
| CA2573976C (en) | 2014-04-29 |
| CA2573976A1 (en) | 2006-04-06 |
| TW200626560A (en) | 2006-08-01 |
| BRPI0515935A (pt) | 2008-08-12 |
| ES2371924T3 (es) | 2012-01-11 |
| KR20070057798A (ko) | 2007-06-07 |
| AR050970A1 (es) | 2006-12-06 |
| WO2006035068A3 (en) | 2006-08-31 |
| EP1797048A2 (de) | 2007-06-20 |
| US20070208022A1 (en) | 2007-09-06 |
| CN101031550A (zh) | 2007-09-05 |
| RU2403244C2 (ru) | 2010-11-10 |
| JP5162245B2 (ja) | 2013-03-13 |
| MX2007003798A (es) | 2007-04-23 |
| RU2007116161A (ru) | 2008-11-10 |
| AU2005288865A1 (en) | 2006-04-06 |
| EP1797048B1 (de) | 2011-08-17 |
| WO2006035068A2 (en) | 2006-04-06 |
| IL180760A (en) | 2013-02-28 |
| AU2005288865B2 (en) | 2012-07-19 |
| BRPI0515935B1 (pt) | 2019-11-19 |
| ZA200702655B (en) | 2008-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |