ATE437875T1 - Heterozyklische antivirale verbindungen - Google Patents

Heterozyklische antivirale verbindungen

Info

Publication number
ATE437875T1
ATE437875T1 AT05777382T AT05777382T ATE437875T1 AT E437875 T1 ATE437875 T1 AT E437875T1 AT 05777382 T AT05777382 T AT 05777382T AT 05777382 T AT05777382 T AT 05777382T AT E437875 T1 ATE437875 T1 AT E437875T1
Authority
AT
Austria
Prior art keywords
antiviral compounds
heterocyclic antiviral
heterocyclic
compounds
antiviral
Prior art date
Application number
AT05777382T
Other languages
English (en)
Inventor
James Blake
Jay Fell
John Fischer
John Robinson
Stacey Spencer
Peter Stengel
Robert HENDRICKS
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE437875T1 publication Critical patent/ATE437875T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05777382T 2004-08-23 2005-08-16 Heterozyklische antivirale verbindungen ATE437875T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60377104P 2004-08-23 2004-08-23
US67771005P 2005-05-04 2005-05-04
PCT/EP2005/008855 WO2006021340A1 (en) 2004-08-23 2005-08-16 Heterocyclic antiviral compounds

Publications (1)

Publication Number Publication Date
ATE437875T1 true ATE437875T1 (de) 2009-08-15

Family

ID=35180855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05777382T ATE437875T1 (de) 2004-08-23 2005-08-16 Heterozyklische antivirale verbindungen

Country Status (19)

Country Link
US (1) US7479489B2 (de)
EP (1) EP1786807B1 (de)
JP (1) JP4624419B2 (de)
KR (1) KR100847181B1 (de)
CN (1) CN101048403B (de)
AR (1) AR050703A1 (de)
AT (1) ATE437875T1 (de)
AU (1) AU2005276648A1 (de)
BR (1) BRPI0514591A (de)
CA (1) CA2577528A1 (de)
DE (1) DE602005015732D1 (de)
ES (1) ES2327764T3 (de)
IL (1) IL181219A0 (de)
MX (1) MX2007002238A (de)
NO (1) NO20071162L (de)
RU (1) RU2007110531A (de)
SG (1) SG137868A1 (de)
TW (1) TWI296626B (de)
WO (1) WO2006021340A1 (de)

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US20080090814A1 (en) * 2006-06-22 2008-04-17 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
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HRP20110193T1 (hr) 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
CL2007003587A1 (es) 2006-12-12 2008-07-04 Anadys Pharmaceuticals Inc Compuestos derivados de pirimidinas sustituidas; composicion farmaceutica que comprende a dichos compuestos y otro agente activo; y su uso para tratar o prevenir la infeccion de la hepatitis c.
US20080214529A1 (en) * 2006-12-12 2008-09-04 Frank Ruebsam SATURATED FUSED [1,2-b]PYRIDAZINONE COMPOUNDS
US20080188466A1 (en) * 2006-12-21 2008-08-07 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
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TWI438206B (zh) 2008-06-10 2014-05-21 Anadys Pharmaceuticals Inc 〔１，２，４〕噻二１，１二氧化物化合物
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2334662A1 (de) * 2008-09-26 2011-06-22 F. Hoffmann-La Roche AG Pyrin- oder pyrazinderivate zur behandlung von hcv
TW201026675A (en) * 2008-10-09 2010-07-16 Anadys Pharmaceuticals Inc 5,6-dihydro-1H-pyridin-2-one compounds
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CN102203090A (zh) * 2008-10-29 2011-09-28 巴斯夫欧洲公司 具有除草作用的取代吡啶
BRPI0919973A2 (pt) * 2008-10-30 2015-12-08 Hoffmann La Roche derivados de arilpiridona antivirais heterocíclicos
JP2012513434A (ja) * 2008-12-22 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス化合物
CA2748057C (en) 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EP2376515A1 (de) * 2008-12-23 2011-10-19 Pharmasset, Inc. Synthese von purinnukleosiden
EP2403844A1 (de) 2009-03-06 2012-01-11 F. Hoffmann-La Roche AG Heterocyclische antivirale verbindungen
EP2421831A1 (de) 2009-04-25 2012-02-29 F. Hoffmann-La Roche AG Heterocyclische antivirale verbindungen
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
SG176976A1 (en) 2009-06-24 2012-02-28 Hoffmann La Roche Heterocyclic antiviral compound
BR112012005616A2 (pt) 2009-09-21 2016-06-21 Hoffmann La Roche compostos antivirais heterocíclicos
BR112012009796A2 (pt) 2009-10-28 2020-08-18 Anadys Pharmaceuticals, Inc. composto, métodos para tratar ou prevenir infecções por vírus da hepatite c em mamífero necessitado destes usos de composto e de composição farmacêutica.
TW201121968A (en) * 2009-11-09 2011-07-01 Intermune Inc Novel inhibitors of hepatitis C virus replication
BR112012012085A2 (pt) 2009-11-21 2016-05-17 Hoffmann La Roche compostos antivirais heterocíclicos
UY33312A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidato de nucleosido de purina
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
CL2011000718A1 (es) 2010-03-31 2012-04-09 Gilead Pharmasset Llc Proceso para la preparacion de compuestos fosforados enantiomericos.
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
AU2012308295B2 (en) 2011-09-16 2017-10-26 Gilead Sciences, Inc. Methods for treating HCV
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MY172166A (en) 2013-01-31 2019-11-15 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
EP3650014B1 (de) 2013-08-27 2021-10-06 Gilead Pharmasset LLC Kombinationsformulierung von zwei antiviralen verbindungen
RU2627499C1 (ru) * 2016-10-11 2017-08-08 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) 4-арил(гетарил)метил-замещенные 8-циклопентиламино-5,7-дифтор-3,4-дигидро-2н-бензо[1,4]тиазин-1,1-диоксиды, обладающие гипертензивным действием
RU2626239C1 (ru) * 2016-10-11 2017-07-25 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Фторированные 4-фурфурил-3,4-дигидро-2н-бензо[1,4]тиазин-1,1-диоксиды, обладающие высокой аритмической активностью
CN110724102B (zh) * 2019-10-25 2021-06-15 华南农业大学 一种含四氢罂粟碱-3-羧酸甲酯的多酚类化合物及其制备方法和应用
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Also Published As

Publication number Publication date
AR050703A1 (es) 2006-11-15
WO2006021340A1 (en) 2006-03-02
JP4624419B2 (ja) 2011-02-02
CN101048403B (zh) 2010-06-16
US7479489B2 (en) 2009-01-20
US20060040927A1 (en) 2006-02-23
KR100847181B1 (ko) 2008-07-17
DE602005015732D1 (de) 2009-09-10
MX2007002238A (es) 2007-04-20
EP1786807A1 (de) 2007-05-23
CN101048403A (zh) 2007-10-03
RU2007110531A (ru) 2008-09-27
TWI296626B (en) 2008-05-11
IL181219A0 (en) 2007-07-04
BRPI0514591A (pt) 2008-06-17
SG137868A1 (en) 2007-12-28
TW200621761A (en) 2006-07-01
KR20070034637A (ko) 2007-03-28
CA2577528A1 (en) 2006-03-02
JP2008510747A (ja) 2008-04-10
AU2005276648A1 (en) 2006-03-02
ES2327764T3 (es) 2009-11-03
EP1786807B1 (de) 2009-07-29
NO20071162L (no) 2007-04-17

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