ATE538130T1 - Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonisten - Google Patents
Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonistenInfo
- Publication number
- ATE538130T1 ATE538130T1 AT06728064T AT06728064T ATE538130T1 AT E538130 T1 ATE538130 T1 AT E538130T1 AT 06728064 T AT06728064 T AT 06728064T AT 06728064 T AT06728064 T AT 06728064T AT E538130 T1 ATE538130 T1 AT E538130T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- pyrimidine derivatives
- pyrimidine
- derivatives
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2005004578 | 2005-04-28 | ||
| IB2005053711 | 2005-11-10 | ||
| PCT/IB2006/051318 WO2006114774A2 (en) | 2005-04-28 | 2006-04-27 | Pyrimidine derivatives and their use as p2y12 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538130T1 true ATE538130T1 (de) | 2012-01-15 |
Family
ID=37075078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06728064T ATE538130T1 (de) | 2005-04-28 | 2006-04-27 | Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8048881B2 (de) |
| EP (1) | EP1893634B1 (de) |
| JP (1) | JP4955658B2 (de) |
| KR (1) | KR101310016B1 (de) |
| CN (1) | CN101166756A (de) |
| AR (1) | AR056992A1 (de) |
| AT (1) | ATE538130T1 (de) |
| AU (1) | AU2006241260A1 (de) |
| BR (1) | BRPI0608089A2 (de) |
| CA (1) | CA2604967C (de) |
| ES (1) | ES2377337T3 (de) |
| IL (1) | IL186939A0 (de) |
| MX (1) | MX2007013436A (de) |
| NO (1) | NO20076094L (de) |
| NZ (1) | NZ563584A (de) |
| RU (1) | RU2410393C2 (de) |
| TW (1) | TW200640877A (de) |
| WO (1) | WO2006114774A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100210635A1 (en) * | 2006-03-29 | 2010-08-19 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) * | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| MX2009011089A (es) | 2007-04-23 | 2009-10-30 | Sanofi Aventis | Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. |
| CN101868469B (zh) * | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| WO2009080226A2 (en) * | 2007-12-26 | 2009-07-02 | Sanofis-Aventis | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
| WO2009080227A2 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| MX2010009561A (es) | 2008-02-29 | 2010-09-24 | Renovis Inc | Compuestos amida, composiciones y usos de los mismos. |
| AR071652A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| BRPI0911393A2 (pt) * | 2008-04-22 | 2015-12-29 | Daiichi Sankyo Co Ltd | composto de 5-hidroxipirimidina-4-carboxamida |
| JP5608655B2 (ja) * | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | Ｐ２ｘ３受容体活性のモジュレーター |
| KR101114503B1 (ko) * | 2008-12-04 | 2012-02-15 | 지에스건설 주식회사 | 부유물 수거장치 |
| MA33260B1 (fr) * | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| SG175297A1 (en) * | 2009-04-22 | 2011-12-29 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
| EP2471792B1 (de) | 2009-08-28 | 2014-04-09 | Daiichi Sankyo Company, Limited | 3-(biaryloxy-)propionsäurederivat |
| WO2013033178A1 (en) | 2011-08-30 | 2013-03-07 | University Of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| JP5941546B2 (ja) | 2011-09-02 | 2016-06-29 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリミジン |
| PT3515924T (pt) | 2016-09-22 | 2022-03-11 | Idorsia Pharmaceuticals Ltd | Formas cristalinas |
| US11179390B2 (en) | 2017-03-15 | 2021-11-23 | Idorsia Pharmaceuticals Ltd | Subcutaneous administration of a P2Y12 receptor antagonist |
| CN112500354A (zh) * | 2020-12-08 | 2021-03-16 | 烟台凯博医药科技有限公司 | 一种4-氯-6-环丙基嘧啶-5-胺的合成方法 |
| WO2025133948A1 (en) | 2023-12-21 | 2025-06-26 | Pfizer Inc. | Acetyl coa-carboxylase (acc) inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
| US6861424B2 (en) * | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| RU2213744C1 (ru) * | 2002-06-27 | 2003-10-10 | Институт органической химии им. Н.Д. Зелинского РАН | ПРОИЗВОДНЫЕ АНТРА[2,1-d]ИЗОТИАЗОЛ-3,6,11-ТРИОНА |
| ES2348942T3 (es) | 2002-12-11 | 2010-12-17 | Bayer Schering Pharma Aktiengesellschaft | Compuestos de 2-aminocarbonil-quinolina como antagonistas del receptor plaquetario de adenosin difosfato. |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| CN101868469B (zh) | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| MA33260B1 (fr) | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| SG175297A1 (en) | 2009-04-22 | 2011-12-29 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
-
2006
- 2006-04-25 TW TW095114722A patent/TW200640877A/zh unknown
- 2006-04-26 AR ARP060101670A patent/AR056992A1/es not_active Application Discontinuation
- 2006-04-27 EP EP06728064A patent/EP1893634B1/de active Active
- 2006-04-27 KR KR1020077026652A patent/KR101310016B1/ko not_active Expired - Fee Related
- 2006-04-27 CN CNA2006800143742A patent/CN101166756A/zh active Pending
- 2006-04-27 US US11/912,545 patent/US8048881B2/en active Active
- 2006-04-27 ES ES06728064T patent/ES2377337T3/es active Active
- 2006-04-27 NZ NZ563584A patent/NZ563584A/en unknown
- 2006-04-27 JP JP2008508400A patent/JP4955658B2/ja not_active Expired - Fee Related
- 2006-04-27 AU AU2006241260A patent/AU2006241260A1/en not_active Withdrawn
- 2006-04-27 AT AT06728064T patent/ATE538130T1/de active
- 2006-04-27 RU RU2007143880/04A patent/RU2410393C2/ru not_active IP Right Cessation
- 2006-04-27 WO PCT/IB2006/051318 patent/WO2006114774A2/en not_active Ceased
- 2006-04-27 CA CA2604967A patent/CA2604967C/en active Active
- 2006-04-27 MX MX2007013436A patent/MX2007013436A/es active IP Right Grant
- 2006-04-27 BR BRPI0608089-8A patent/BRPI0608089A2/pt not_active IP Right Cessation
-
2007
- 2007-10-25 IL IL186939A patent/IL186939A0/en unknown
- 2007-11-27 NO NO20076094A patent/NO20076094L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008539224A (ja) | 2008-11-13 |
| CA2604967A1 (en) | 2006-11-02 |
| JP4955658B2 (ja) | 2012-06-20 |
| NZ563584A (en) | 2011-03-31 |
| RU2007143880A (ru) | 2009-06-10 |
| NO20076094L (no) | 2008-01-25 |
| KR101310016B1 (ko) | 2013-09-30 |
| US20080194576A1 (en) | 2008-08-14 |
| BRPI0608089A2 (pt) | 2009-11-10 |
| RU2410393C2 (ru) | 2011-01-27 |
| KR20080004608A (ko) | 2008-01-09 |
| IL186939A0 (en) | 2008-02-09 |
| MX2007013436A (es) | 2008-01-16 |
| EP1893634B1 (de) | 2011-12-21 |
| ES2377337T3 (es) | 2012-03-26 |
| US8048881B2 (en) | 2011-11-01 |
| CN101166756A (zh) | 2008-04-23 |
| EP1893634A2 (de) | 2008-03-05 |
| AU2006241260A1 (en) | 2006-11-02 |
| CA2604967C (en) | 2014-04-01 |
| AR056992A1 (es) | 2007-11-07 |
| WO2006114774A2 (en) | 2006-11-02 |
| WO2006114774A3 (en) | 2007-02-08 |
| TW200640877A (en) | 2006-12-01 |
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