ATE471938T1 - Substituierte diazaspiroä4.5üdecanderivate und deren verwendung als neurokininantagonisten - Google Patents

Substituierte diazaspiroä4.5üdecanderivate und deren verwendung als neurokininantagonisten

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Publication number
ATE471938T1
ATE471938T1 AT05729796T AT05729796T ATE471938T1 AT E471938 T1 ATE471938 T1 AT E471938T1 AT 05729796 T AT05729796 T AT 05729796T AT 05729796 T AT05729796 T AT 05729796T AT E471938 T1 ATE471938 T1 AT E471938T1
Authority
AT
Austria
Prior art keywords
derivatives
substituted
neurokin antagonists
neurokin
antagonists
Prior art date
Application number
AT05729796T
Other languages
English (en)
Inventor
Frans Janssens
Bruno Schoentjes
Sophie Coupa
Alain Poncelet
Yvan Simonnet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34957501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE471938(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE471938T1 publication Critical patent/ATE471938T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
AT05729796T 2004-04-06 2005-04-04 Substituierte diazaspiroä4.5üdecanderivate und deren verwendung als neurokininantagonisten ATE471938T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004050458 2004-04-06
PCT/EP2005/051506 WO2005097794A1 (en) 2004-04-06 2005-04-04 Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

Publications (1)

Publication Number Publication Date
ATE471938T1 true ATE471938T1 (de) 2010-07-15

Family

ID=34957501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05729796T ATE471938T1 (de) 2004-04-06 2005-04-04 Substituierte diazaspiroä4.5üdecanderivate und deren verwendung als neurokininantagonisten

Country Status (13)

Country Link
US (1) US7612056B2 (de)
EP (1) EP1735313B1 (de)
JP (1) JP4884371B2 (de)
CN (1) CN100591682C (de)
AR (1) AR048521A1 (de)
AT (1) ATE471938T1 (de)
AU (1) AU2005231984B2 (de)
CA (1) CA2561975C (de)
DE (1) DE602005021959D1 (de)
ES (1) ES2346985T3 (de)
JO (1) JO2676B1 (de)
TW (1) TWI360548B (de)
WO (1) WO2005097794A1 (de)

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WO2006094948A1 (en) * 2005-03-08 2006-09-14 Janssen Pharmaceutica N.V. Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists
WO2007039123A2 (en) * 2005-09-22 2007-04-12 Smithkline Beecham Corporation Combination therapy comprising an nk-3 antagonist and an antipsychotic agent
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
CN101875658B (zh) * 2009-04-28 2013-01-09 上海药明康德新药开发有限公司 3-羰基-2,8-二氮杂螺[4.5] 癸烷-8-羧酸叔丁酯的制备方法
CN102740693A (zh) * 2009-09-04 2012-10-17 统一帕拉贡联合有限公司 用于治疗与神经激肽2受体活性相关的病症或疾病的化合物
CN102070634B (zh) * 2009-11-24 2013-04-10 上海药明康德新药开发有限公司 一种带保护基的1,7-二氮杂螺[4,5]葵烷的合成方法
ES2579616T3 (es) * 2011-10-18 2016-08-12 Helsinn Healthcare Sa Combinaciones terapéuticas de netupitant y palonosetrón
JP6902682B2 (ja) 2015-05-18 2021-07-14 カンディー セラピューティクス リミテッド 性ホルモン依存性疾患を治療するためのｎｋ−１／ｎｋ−３受容体デュアルアンタゴニスト
PL3722284T3 (pl) 2016-01-13 2025-03-31 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
PL3402784T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-alkilo-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekanu
MX379201B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
LT3402782T (lt) 2016-01-13 2020-10-12 Grünenthal GmbH 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekano dariniai
MX378995B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
EA202092131A1 (ru) 2018-03-14 2020-11-27 Кэнди Терапьютикс Лимитед Новый фармацевтический препарат, содержащий двойные антагонисты рецептора nk-1/nk-3
WO2020249689A1 (en) 2019-06-12 2020-12-17 Nouryon Chemicals International B.V. Process for the production of peroxyesters
ES2963357T3 (es) 2019-06-12 2024-03-26 Nouryon Chemicals Int Bv Proceso para la producción de peróxidos de diacilo
US20220306490A1 (en) * 2019-06-12 2022-09-29 Nouryon Chemicals International B.V. Method for isolating carboxylic acid from an aqueous side stream
ES2963382T3 (es) 2019-06-12 2024-03-26 Nouryon Chemicals Int Bv Proceso para la producción de peróxidos de diacilo
ES2961184T3 (es) 2019-06-12 2024-03-08 Nouryon Chemicals Int Bv Proceso para la producción de peróxidos de diacilo
US12533358B1 (en) 2025-05-14 2026-01-27 Bayer Consumer Care Ag Methods of treatment with elinzanetant

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JO2676B1 (en) 2012-06-17
ES2346985T3 (es) 2010-10-22
EP1735313A1 (de) 2006-12-27
EP1735313B1 (de) 2010-06-23
US20070254904A1 (en) 2007-11-01
AR048521A1 (es) 2006-05-03
CA2561975A1 (en) 2005-10-20
DE602005021959D1 (de) 2010-08-05
WO2005097794A1 (en) 2005-10-20
AU2005231984A1 (en) 2005-10-20
CA2561975C (en) 2012-12-11
US7612056B2 (en) 2009-11-03
TW200604198A (en) 2006-02-01
CN1946723A (zh) 2007-04-11
AU2005231984B2 (en) 2011-03-03
TWI360548B (en) 2012-03-21
JP2007531786A (ja) 2007-11-08
CN100591682C (zh) 2010-02-24
JP4884371B2 (ja) 2012-02-29

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