DE602005021959D1 - Substituierte diazaspiroä4.5üdecanderivate und der - Google Patents

Substituierte diazaspiroä4.5üdecanderivate und der

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Publication number
DE602005021959D1
DE602005021959D1 DE602005021959T DE602005021959T DE602005021959D1 DE 602005021959 D1 DE602005021959 D1 DE 602005021959D1 DE 602005021959 T DE602005021959 T DE 602005021959T DE 602005021959 T DE602005021959 T DE 602005021959T DE 602005021959 D1 DE602005021959 D1 DE 602005021959D1
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DE
Germany
Prior art keywords
der
substituted
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021959T
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English (en)
Inventor
Frans Eduard Janssens
Bruno Schoentjes
Sophie Coupa
Alain Philippe Poncelet
Yvan Rene Simonnet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34957501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005021959(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005021959D1 publication Critical patent/DE602005021959D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Pregnancy & Childbirth (AREA)
DE602005021959T 2004-04-06 2005-04-04 Substituierte diazaspiroä4.5üdecanderivate und der Active DE602005021959D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004050458 2004-04-06
PCT/EP2005/051506 WO2005097794A1 (en) 2004-04-06 2005-04-04 Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

Publications (1)

Publication Number Publication Date
DE602005021959D1 true DE602005021959D1 (de) 2010-08-05

Family

ID=34957501

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021959T Active DE602005021959D1 (de) 2004-04-06 2005-04-04 Substituierte diazaspiroä4.5üdecanderivate und der

Country Status (13)

Country Link
US (1) US7612056B2 (de)
EP (1) EP1735313B1 (de)
JP (1) JP4884371B2 (de)
CN (1) CN100591682C (de)
AR (1) AR048521A1 (de)
AT (1) ATE471938T1 (de)
AU (1) AU2005231984B2 (de)
CA (1) CA2561975C (de)
DE (1) DE602005021959D1 (de)
ES (1) ES2346985T3 (de)
JO (1) JO2676B1 (de)
TW (1) TWI360548B (de)
WO (1) WO2005097794A1 (de)

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EP1781288A2 (de) * 2004-08-19 2007-05-09 Vertex Pharmaceuticals Incorporated Modulatoren von muskarinischen rezeptoren
ATE478075T1 (de) * 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
WO2007039123A2 (en) * 2005-09-22 2007-04-12 Smithkline Beecham Corporation Combination therapy comprising an nk-3 antagonist and an antipsychotic agent
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
CN101875658B (zh) * 2009-04-28 2013-01-09 上海药明康德新药开发有限公司 3-羰基-2,8-二氮杂螺[4.5] 癸烷-8-羧酸叔丁酯的制备方法
NZ599215A (en) * 2009-09-04 2014-11-28 United Paragon Associates Inc Compounds for treating disorders or diseases associated with neurokinin 2 receptor activity
CN102070634B (zh) * 2009-11-24 2013-04-10 上海药明康德新药开发有限公司 一种带保护基的1,7-二氮杂螺[4,5]葵烷的合成方法
JP2014530249A (ja) * 2011-10-18 2014-11-17 ヘルシン ヘルスケア ソシエテ アノニム ネツピタントおよびパロノセトロンの治療学的組合せ
MX2017012720A (es) 2015-05-18 2018-02-09 Nerre Therapeutics Ltd Antagonistas duales de receptores de neurocinina-1 (nk-1) / neurocinina-3 (nk-3) para el tratamiento de enfermedades dependientes de hormonas sexuales.
CA3011180A1 (en) 2016-01-13 2017-07-20 Grunenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
WO2017121650A1 (en) 2016-01-13 2017-07-20 Grünenthal GmbH 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
RS60223B1 (sr) 2016-01-13 2020-06-30 Gruenenthal Gmbh Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
EP3402784B1 (de) 2016-01-13 2020-03-11 Grünenthal GmbH 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivate
EA037598B1 (ru) 2016-01-13 2021-04-20 Грюненталь Гмбх Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диазаспиро[4,5]декана
KR20200139138A (ko) 2018-03-14 2020-12-11 칸디 테라퓨틱스 리미티드 이중 nk-1/nk-3 수용체 길항제를 포함하는 신규한 제약 제제
EP3983340B1 (de) * 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Verfahren zur isolierung von carbonsäure aus einem wässrigen seitenstrom

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TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
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CA2561975C (en) 2012-12-11
JP2007531786A (ja) 2007-11-08
AU2005231984A1 (en) 2005-10-20
CN1946723A (zh) 2007-04-11
JP4884371B2 (ja) 2012-02-29
JO2676B1 (en) 2012-06-17
AU2005231984B2 (en) 2011-03-03
ATE471938T1 (de) 2010-07-15
WO2005097794A1 (en) 2005-10-20
ES2346985T3 (es) 2010-10-22
US7612056B2 (en) 2009-11-03
TWI360548B (en) 2012-03-21
US20070254904A1 (en) 2007-11-01
TW200604198A (en) 2006-02-01
CN100591682C (zh) 2010-02-24
EP1735313A1 (de) 2006-12-27
EP1735313B1 (de) 2010-06-23
CA2561975A1 (en) 2005-10-20

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