DE60005545D1 - Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation - Google Patents

Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation

Info

Publication number
DE60005545D1
DE60005545D1 DE60005545T DE60005545T DE60005545D1 DE 60005545 D1 DE60005545 D1 DE 60005545D1 DE 60005545 T DE60005545 T DE 60005545T DE 60005545 T DE60005545 T DE 60005545T DE 60005545 D1 DE60005545 D1 DE 60005545D1
Authority
DE
Germany
Prior art keywords
fibrinogen
pyridyl
inhibitors
spirocyclic compounds
blood plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005545T
Other languages
English (en)
Inventor
M Scarborough
Mukund Mehrota
Anjali Pandey
Mark Smyth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60005545D1 publication Critical patent/DE60005545D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
DE60005545T 1999-10-27 2000-10-27 Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation Expired - Lifetime DE60005545D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16182599P 1999-10-27 1999-10-27
PCT/US2000/029804 WO2001030780A2 (en) 1999-10-27 2000-10-27 Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation

Publications (1)

Publication Number Publication Date
DE60005545D1 true DE60005545D1 (de) 2003-10-30

Family

ID=22582914

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60005545T Expired - Lifetime DE60005545D1 (de) 1999-10-27 2000-10-27 Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation

Country Status (8)

Country Link
US (1) US20030055244A1 (de)
EP (1) EP1224186B1 (de)
JP (1) JP2003514777A (de)
AT (1) ATE250604T1 (de)
AU (1) AU1244001A (de)
CA (1) CA2389034A1 (de)
DE (1) DE60005545D1 (de)
WO (1) WO2001030780A2 (de)

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WO2006000096A1 (en) * 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
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US8158825B2 (en) 2005-06-24 2012-04-17 Merck Sharp & Dohme Corp. Modified malonate derivatives
AR057579A1 (es) 2005-11-23 2007-12-05 Merck & Co Inc Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
AR057965A1 (es) 2005-12-05 2007-12-26 Incyte Corp Compuestos de lactama y metodos de uso de los mismos
CA2642813A1 (en) 2006-02-28 2007-09-07 Merck & Co., Inc. Inhibitors of histone deacetylase
WO2007127137A2 (en) 2006-04-26 2007-11-08 Merck & Co., Inc. Disubstituted aniline compounds
US8119652B2 (en) 2006-05-18 2012-02-21 Merck Sharp & Dohme Corp. Aryl-fused spirocyclic compounds
CA2657288A1 (en) 2006-07-20 2008-01-24 Merck & Co., Inc. Phosphorus derivatives as histone deacetylase inhibitors
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
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JP2010531358A (ja) 2007-06-27 2010-09-24 メルク・シャープ・エンド・ドーム・コーポレイション ヒストン脱アセチル化酵素阻害剤としてのピリジル及びピリミジニル誘導体
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
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US9708270B2 (en) 2012-10-11 2017-07-18 Merck Sharp & Dohme Corp. Substituted spiropiperidinyl compounds useful as GPR120 agonists
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UA118201C2 (uk) 2013-11-26 2018-12-10 Ф. Хоффманн-Ля Рош Аг НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
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CN104628625A (zh) * 2014-12-23 2015-05-20 安徽德信佳生物医药有限公司 一种N-boc-4-羟基哌啶合成方法
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RU2018114289A (ru) 2015-09-24 2019-10-24 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов аутотаксина (atx)
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
EP3353181B1 (de) 2015-09-24 2021-08-11 F. Hoffmann-La Roche AG Als atx-inhibitoren geeignete bicyclische verbindungen
MX2018001890A (es) 2015-09-24 2018-06-20 Hoffmann La Roche Compuestos biciclicos como inhibidores de autotaxina (atx).
CR20190423A (es) 2017-03-16 2019-11-01 Hoffmann La Roche Nuevos compuestos biciclícos como inhibidores dobles de atx/ca
EP3596060B1 (de) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG Neue bicyclische verbindungen als atx-inhibitoren

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ES2227612T3 (es) * 1995-09-29 2005-04-01 Eli Lilly And Company Compuestos espiro como inhibidores de agregacion plaquetaria dependiente del fibrinogeno.

Also Published As

Publication number Publication date
EP1224186B1 (de) 2003-09-24
WO2001030780A2 (en) 2001-05-03
AU1244001A (en) 2001-05-08
EP1224186A2 (de) 2002-07-24
WO2001030780A3 (en) 2001-11-29
US20030055244A1 (en) 2003-03-20
CA2389034A1 (en) 2001-05-03
ATE250604T1 (de) 2003-10-15
JP2003514777A (ja) 2003-04-22

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