BRPI0514509A - uso de composto n-aril diazaespiracìclicos no tratamento de dependência - Google Patents
uso de composto n-aril diazaespiracìclicos no tratamento de dependênciaInfo
- Publication number
- BRPI0514509A BRPI0514509A BRPI0514509-0A BRPI0514509A BRPI0514509A BR PI0514509 A BRPI0514509 A BR PI0514509A BR PI0514509 A BRPI0514509 A BR PI0514509A BR PI0514509 A BRPI0514509 A BR PI0514509A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- significant
- effective
- aryl
- effects
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
USO DE COMPOSTOS N-ARIL DIAZAESPIRACìCLICOS NO TRATAMENTO DE DEPENDêNCIA. A presente invenção refere-se a compostos, composições e métodos para tratamento de dependência de droga, dependência de nicotina e/ou obesidade. Os compostos são compostos N-arila diazaespirocílicos, análogos ligados por ponte de compostos N-heteroarila diazaespirocíclicos, ou pró-drogas ou metabolitos desses compostos. O grupo adia pode ser um anel heterocíclico (heteroarila) de cinco ou seis membros. Os compostos são eficazes na inibição da produção e/ou secreção de dopamina, e por conseguinte são eficazes na inibição do processo de recompensa fisiológica que está associado com a ingestão de nicotina e/ou drogas ilícitas. Os compostos e as composições podem ser administrados em quantidades eficazes para inibir a liberação de dopamina, sem resultar em efeitos colaterais adversos significativos (por exemplo, efeitos colaterais tais como aumentos significativos da pressão sangüínea e da freqüência cardíaca, efeitos negativos significativos sobre o trato gastrointestinal, e efeitos significativos sobre o músculo esquelético).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60347904P | 2004-08-20 | 2004-08-20 | |
PCT/US2005/029371 WO2006023630A2 (en) | 2004-08-20 | 2005-08-18 | The use of n-aryl diazaspiracyclic compounds in the treatment of addiction |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0514509A true BRPI0514509A (pt) | 2008-06-10 |
Family
ID=35447974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0514509-0A BRPI0514509A (pt) | 2004-08-20 | 2005-08-18 | uso de composto n-aril diazaespiracìclicos no tratamento de dependência |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060058328A1 (pt) |
EP (1) | EP1784184A2 (pt) |
JP (1) | JP2008510711A (pt) |
KR (1) | KR20070043008A (pt) |
CN (1) | CN101022801A (pt) |
AU (1) | AU2005277410B2 (pt) |
BR (1) | BRPI0514509A (pt) |
CA (1) | CA2575461A1 (pt) |
IL (1) | IL180929A0 (pt) |
MX (1) | MX2007002045A (pt) |
NO (1) | NO20070979L (pt) |
NZ (1) | NZ552792A (pt) |
RU (1) | RU2387647C9 (pt) |
UA (1) | UA92327C2 (pt) |
WO (1) | WO2006023630A2 (pt) |
ZA (1) | ZA200701193B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
PT1578422E (pt) | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
JP5694645B2 (ja) | 2006-03-16 | 2015-04-01 | ニコノヴァム エービーNiconovum Ab | 改善された嗅ぎたばこ組成物 |
US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
WO2008096746A1 (ja) * | 2007-02-06 | 2008-08-14 | Takeda Pharmaceutical Company Limited | スピロ化合物およびその用途 |
WO2009091561A1 (en) * | 2008-01-15 | 2009-07-23 | Targacept, Inc. | Preparation and enantiomeric separation of 7-(3-pyridinyl)-1,7-diazaspiro[4.4] nonane and novel salt forms of the racemate and enantiomers |
CN102070640A (zh) * | 2009-11-24 | 2011-05-25 | 上海药明康德新药开发有限公司 | 一种1,7-二氮杂螺[4,5]壬烷及其衍生物的合成方法 |
MX337106B (es) * | 2010-05-27 | 2016-02-12 | Targacept Inc | Antagonistas no competitivos de receptores nicotinicos. |
CN102267995A (zh) * | 2010-06-04 | 2011-12-07 | 艾琪康医药科技(上海)有限公司 | 一种制备二氮杂螺环化合物的方法 |
CN102516146B (zh) * | 2011-11-24 | 2013-10-02 | 爱斯特(成都)生物制药有限公司 | 5位为氮的四元氮杂螺环衍生物及其制备方法和用途 |
GB201416351D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Heterocyclic derivatives |
GB201416352D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
RU2635105C1 (ru) * | 2016-07-15 | 2017-11-09 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" | Способ получения 4-арил-2,7,9-триазаспиро[4.5]декан-6,8,10-трионов |
AU2017306152A1 (en) * | 2016-08-01 | 2019-01-31 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN116057045A (zh) | 2020-06-05 | 2023-05-02 | 金耐特生物制药公司 | 成纤维细胞生长因子受体激酶抑制剂 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3282947A (en) * | 1962-05-17 | 1966-11-01 | Geschickter Fund Med Res | Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds |
US4922901A (en) * | 1988-09-08 | 1990-05-08 | R. J. Reynolds Tobacco Company | Drug delivery articles utilizing electrical energy |
EP0687268B1 (en) * | 1993-03-04 | 1998-05-27 | Pfizer Inc. | Spiroazacyclic derivatives as substance p antagonists |
US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
EP0842172A1 (en) * | 1995-06-29 | 1998-05-20 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
US5616716A (en) * | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
US5663356A (en) * | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
DK0970957T3 (da) * | 1998-06-12 | 2001-12-03 | Hoffmann La Roche | Diaza-spiro[3.5]nonan-derivativer |
EP1224186B1 (en) * | 1999-10-27 | 2003-09-24 | Millennium Pharmaceuticals, Inc. | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
EA005409B1 (ru) * | 2000-04-10 | 2005-02-24 | Пфайзер Продактс Инк. | Производные бензамидопиперидина в качестве антагонистов рецепторов вещества p |
NZ551552A (en) * | 2002-07-05 | 2008-03-28 | Targacept Inc | N-Aryl diazaspirocyclic compounds capable of affecting nicotinic cholinergic receptors and methods of preparation and use thereof |
-
2005
- 2005-08-18 CN CNA200580031767XA patent/CN101022801A/zh active Pending
- 2005-08-18 WO PCT/US2005/029371 patent/WO2006023630A2/en active Application Filing
- 2005-08-18 RU RU2007110020/04A patent/RU2387647C9/ru not_active IP Right Cessation
- 2005-08-18 KR KR1020077003860A patent/KR20070043008A/ko not_active Application Discontinuation
- 2005-08-18 BR BRPI0514509-0A patent/BRPI0514509A/pt not_active IP Right Cessation
- 2005-08-18 NZ NZ552792A patent/NZ552792A/en not_active IP Right Cessation
- 2005-08-18 UA UAA200702904A patent/UA92327C2/ru unknown
- 2005-08-18 JP JP2007528005A patent/JP2008510711A/ja not_active Withdrawn
- 2005-08-18 CA CA002575461A patent/CA2575461A1/en not_active Abandoned
- 2005-08-18 AU AU2005277410A patent/AU2005277410B2/en not_active Ceased
- 2005-08-18 MX MX2007002045A patent/MX2007002045A/es active IP Right Grant
- 2005-08-18 EP EP05786530A patent/EP1784184A2/en not_active Withdrawn
- 2005-08-18 US US11/207,102 patent/US20060058328A1/en not_active Abandoned
-
2007
- 2007-01-24 IL IL180929A patent/IL180929A0/en unknown
- 2007-02-09 ZA ZA200701193A patent/ZA200701193B/xx unknown
- 2007-02-21 NO NO20070979A patent/NO20070979L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ552792A (en) | 2009-12-24 |
JP2008510711A (ja) | 2008-04-10 |
UA92327C2 (ru) | 2010-10-25 |
AU2005277410B2 (en) | 2010-06-24 |
EP1784184A2 (en) | 2007-05-16 |
AU2005277410A1 (en) | 2006-03-02 |
ZA200701193B (en) | 2009-09-30 |
NO20070979L (no) | 2007-03-19 |
RU2007110020A (ru) | 2008-09-27 |
WO2006023630A2 (en) | 2006-03-02 |
IL180929A0 (en) | 2007-07-24 |
CA2575461A1 (en) | 2006-03-02 |
WO2006023630A3 (en) | 2006-05-04 |
US20060058328A1 (en) | 2006-03-16 |
RU2387647C2 (ru) | 2010-04-27 |
CN101022801A (zh) | 2007-08-22 |
RU2387647C9 (ru) | 2011-05-27 |
KR20070043008A (ko) | 2007-04-24 |
MX2007002045A (es) | 2007-03-29 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |