EA201591532A1 - Ингибиторы carm1 и их применение - Google Patents

Ингибиторы carm1 и их применение

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Publication number
EA201591532A1
EA201591532A1 EA201591532A EA201591532A EA201591532A1 EA 201591532 A1 EA201591532 A1 EA 201591532A1 EA 201591532 A EA201591532 A EA 201591532A EA 201591532 A EA201591532 A EA 201591532A EA 201591532 A1 EA201591532 A1 EA 201591532A1
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EA
Eurasian Patent Office
Prior art keywords
carm1
compounds
application
formula
inhibitors
Prior art date
Application number
EA201591532A
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English (en)
Inventor
Ричард Чесуорт
Оскар Мигель Морадей
Гидеон Шапиро
Лей Дзин
Роберт И. Бабин
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Эпизим, Инк.
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Application filed by Эпизим, Инк. filed Critical Эпизим, Инк.
Publication of EA201591532A1 publication Critical patent/EA201591532A1/ru

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Abstract

В настоящем документе представлены соединения формулы (I)и их фармацевтически приемлемые соли, и фармацевтические композиции с ними; где X, R, R, R, R, R, Rопределены в настоящем документе, и кольцо НЕТ является 6-членной моноциклической гетероарильной кольцевой системой с формулойгде L, R, G, G, Gи Gопределены в настоящем документе. Соединения в соответствии с настоящим изобретением применимы для ингибирования активности CARM1. Также описываются способы применения соединений для лечения опосредованных CARM1 нарушений.
EA201591532A 2013-03-15 2014-03-14 Ингибиторы carm1 и их применение EA201591532A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794442P 2013-03-15 2013-03-15
US201461937333P 2014-02-07 2014-02-07
PCT/US2014/028463 WO2014144169A1 (en) 2013-03-15 2014-03-14 Carm1 inhibitors and uses thereof

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EA201591532A1 true EA201591532A1 (ru) 2016-03-31

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US (6) US9738651B2 (ru)
EP (1) EP2970219B1 (ru)
JP (2) JP2016519078A (ru)
KR (1) KR20160003647A (ru)
CN (1) CN105228997B (ru)
AU (2) AU2014227775B2 (ru)
BR (1) BR112015022787A2 (ru)
CA (1) CA2903813C (ru)
EA (1) EA201591532A1 (ru)
HK (1) HK1219947A1 (ru)
IL (1) IL241370A0 (ru)
MX (1) MX2015012803A (ru)
SG (1) SG11201507070XA (ru)
WO (1) WO2014144169A1 (ru)

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