ATE534649T1 - Imidazothiazole und imidazoxazolderivative als inhibitoren von p38 - Google Patents
Imidazothiazole und imidazoxazolderivative als inhibitoren von p38Info
- Publication number
- ATE534649T1 ATE534649T1 AT04752390T AT04752390T ATE534649T1 AT E534649 T1 ATE534649 T1 AT E534649T1 AT 04752390 T AT04752390 T AT 04752390T AT 04752390 T AT04752390 T AT 04752390T AT E534649 T1 ATE534649 T1 AT E534649T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazoxazole
- imidazothiazoles
- inhibitors
- derivatives
- inhibiting
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47073503P | 2003-05-15 | 2003-05-15 | |
US51229803P | 2003-10-17 | 2003-10-17 | |
PCT/US2004/015368 WO2004110990A2 (en) | 2003-05-15 | 2004-05-14 | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE534649T1 true ATE534649T1 (de) | 2011-12-15 |
Family
ID=33555294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04752390T ATE534649T1 (de) | 2003-05-15 | 2004-05-14 | Imidazothiazole und imidazoxazolderivative als inhibitoren von p38 |
Country Status (9)
Country | Link |
---|---|
US (2) | US7902192B2 (de) |
EP (2) | EP1633758B1 (de) |
JP (1) | JP4939220B2 (de) |
KR (1) | KR20060025141A (de) |
AT (1) | ATE534649T1 (de) |
AU (1) | AU2004247626B8 (de) |
CA (1) | CA2526285A1 (de) |
MX (1) | MXPA05012377A (de) |
WO (1) | WO2004110990A2 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
US7902192B2 (en) | 2003-05-15 | 2011-03-08 | Arqule, Inc. | Inhibitors of P38 and methods of using the same |
MY143245A (en) | 2004-04-28 | 2011-04-15 | Mitsubishi Tanabe Pharma Corp | 4- 2-(cycloalkylamino)pyrimidin-4-yl-(phenyl)-imidazolin-2-one derivatives as p38 map-kinase inhibitors for the treatment of inflammatory diseases |
EP1809636A1 (de) * | 2004-10-19 | 2007-07-25 | Arqule, Inc. | Synthese aus imidazooxazol- und imidazothiazol-hemmern der p38-map-kinase |
US7501430B2 (en) * | 2006-04-17 | 2009-03-10 | Arqule, Inc. | RAF inhibitors and their uses |
EP2018380B1 (de) * | 2006-05-19 | 2011-10-19 | Abbott Laboratories | CNS-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische Alkanderivate |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
CA2704282A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
US8188083B2 (en) | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
CA2700893A1 (en) | 2007-10-12 | 2009-04-16 | Arqule, Inc. | Substituted tetrazole compounds and uses thereof |
US8067409B2 (en) | 2007-11-27 | 2011-11-29 | Abbott Laboratories | Protein kinase inhibitors |
JP2012511021A (ja) | 2008-12-05 | 2012-05-17 | アークル インコーポレイテッド | Rafの阻害剤およびその使用 |
EP2432767B1 (en) * | 2009-05-19 | 2013-06-26 | Dow AgroSciences LLC | Compounds and methods for controlling fungi |
GB201321731D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
US11332479B2 (en) | 2016-07-05 | 2022-05-17 | Korea Institute Of Science And Technology | Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same |
KR101948805B1 (ko) * | 2016-07-05 | 2019-02-15 | 한국과학기술연구원 | 항종양 효과를 갖는 이미다조옥사졸 유도체 및 이를 포함하는 약학적 조성물 |
US10988477B2 (en) * | 2018-01-29 | 2021-04-27 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
CN113121564A (zh) * | 2019-12-31 | 2021-07-16 | 韩国科学技术研究院 | 具有抗肿瘤效果的咪唑并恶唑衍生物及包括其的药物组合物 |
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KR920702621A (ko) | 1989-06-13 | 1992-10-06 | 스튜어트 알. 슈터 | 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제 |
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EP1140840B1 (de) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
IL146309A0 (en) | 1999-05-21 | 2002-07-25 | Scios Inc | Indole-type derivatives as inhibitors of p38 kinase |
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-
2004
- 2004-05-14 US US10/556,161 patent/US7902192B2/en not_active Expired - Fee Related
- 2004-05-14 WO PCT/US2004/015368 patent/WO2004110990A2/en active Application Filing
- 2004-05-14 EP EP04752390A patent/EP1633758B1/de not_active Expired - Lifetime
- 2004-05-14 EP EP10175256A patent/EP2251343A1/de not_active Withdrawn
- 2004-05-14 CA CA002526285A patent/CA2526285A1/en not_active Abandoned
- 2004-05-14 JP JP2006533130A patent/JP4939220B2/ja not_active Expired - Lifetime
- 2004-05-14 MX MXPA05012377A patent/MXPA05012377A/es active IP Right Grant
- 2004-05-14 AT AT04752390T patent/ATE534649T1/de active
- 2004-05-14 KR KR1020057021750A patent/KR20060025141A/ko not_active Application Discontinuation
- 2004-05-14 AU AU2004247626A patent/AU2004247626B8/en not_active Ceased
-
2010
- 2010-12-03 US US12/960,079 patent/US20110301160A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006528983A (ja) | 2006-12-28 |
CA2526285A1 (en) | 2004-12-23 |
MXPA05012377A (es) | 2006-05-25 |
EP1633758A2 (de) | 2006-03-15 |
US20070270418A1 (en) | 2007-11-22 |
WO2004110990A2 (en) | 2004-12-23 |
WO2004110990A3 (en) | 2005-03-24 |
KR20060025141A (ko) | 2006-03-20 |
EP1633758B1 (de) | 2011-11-23 |
AU2004247626B2 (en) | 2011-01-20 |
JP4939220B2 (ja) | 2012-05-23 |
US20110301160A1 (en) | 2011-12-08 |
AU2004247626B8 (en) | 2011-05-19 |
AU2004247626A1 (en) | 2004-12-23 |
EP2251343A1 (de) | 2010-11-17 |
US7902192B2 (en) | 2011-03-08 |
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