EA200800374A1 - 1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции - Google Patents

1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции

Info

Publication number
EA200800374A1
EA200800374A1 EA200800374A EA200800374A EA200800374A1 EA 200800374 A1 EA200800374 A1 EA 200800374A1 EA 200800374 A EA200800374 A EA 200800374A EA 200800374 A EA200800374 A EA 200800374A EA 200800374 A1 EA200800374 A1 EA 200800374A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dihydropyridin
production
methods
containing compositions
condensed heterocycles
Prior art date
Application number
EA200800374A
Other languages
English (en)
Other versions
EA016815B1 (ru
Inventor
Жак Може
Анил Наир
Нина Ма
Кирстен Бьергард
Брюно Филош-Ромм
Одиль Ангуйан-Бонифас
Серж Миньяни
Жан-Кристоф Карри
Франсуа Клерк
Эрве Мину
Лоран Шио
Сесиль Комбо
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200800374A1 publication Critical patent/EA200800374A1/ru
Publication of EA016815B1 publication Critical patent/EA016815B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Изобретение относится к 1,4-дигидропиридин-конденсированным гетероциклам, способу их получения, применению и содержащим их композициям. Изобретение касается замещенных дигидропиридин-конденсированных гетероциклов, которые можно использовать для лечения ракового заболевания, в особенности для предотвращения деления раковых клеток. Данные соединения действуют как ингибиторы киназ Aurora А и/или В.
EA200800374A 2005-07-20 2006-07-18 1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции EA016815B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (en) 2005-07-20 2005-07-20 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
PCT/IB2006/002734 WO2007012972A2 (en) 2005-07-20 2006-07-18 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (2)

Publication Number Publication Date
EA200800374A1 true EA200800374A1 (ru) 2008-08-29
EA016815B1 EA016815B1 (ru) 2012-07-30

Family

ID=35510894

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800374A EA016815B1 (ru) 2005-07-20 2006-07-18 1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции

Country Status (37)

Country Link
US (1) US8163768B2 (ru)
EP (2) EP1746097B1 (ru)
JP (2) JP2009501778A (ru)
KR (1) KR101286796B1 (ru)
CN (1) CN101243087B (ru)
AR (1) AR054845A1 (ru)
AT (2) ATE455115T1 (ru)
AU (1) AU2006273692B8 (ru)
BR (1) BRPI0614002A2 (ru)
CA (1) CA2615700C (ru)
CR (1) CR9663A (ru)
CY (1) CY1109964T1 (ru)
DE (1) DE602005018911D1 (ru)
DK (1) DK1746097T3 (ru)
DO (1) DOP2006000175A (ru)
EA (1) EA016815B1 (ru)
EC (1) ECSP078062A (ru)
ES (1) ES2339676T3 (ru)
HN (1) HN2008000088A (ru)
HR (1) HRP20100195T1 (ru)
IL (1) IL188861A0 (ru)
MA (1) MA29634B1 (ru)
MX (1) MX2008000902A (ru)
MY (1) MY148617A (ru)
NO (1) NO20080831L (ru)
NZ (1) NZ592766A (ru)
PE (2) PE20070212A1 (ru)
PL (1) PL1746097T3 (ru)
PT (1) PT1746097E (ru)
RS (1) RS51351B (ru)
SI (1) SI1746097T1 (ru)
TN (1) TNSN08020A1 (ru)
TW (1) TWI386411B (ru)
UA (1) UA98928C2 (ru)
UY (1) UY29685A1 (ru)
WO (1) WO2007012972A2 (ru)
ZA (1) ZA200800542B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
AU2013261128B2 (en) 2012-05-15 2015-11-12 Novartis Ag Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
EP2861576B1 (en) 2012-05-15 2018-01-10 Novartis AG Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
WO2013171641A1 (en) 2012-05-15 2013-11-21 Novartis Ag Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1
MY169377A (en) 2012-05-15 2019-03-26 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
CA2887701C (en) 2012-10-12 2020-12-15 The Broad Institute, Inc. Gsk3 inhibitors and methods of use thereof
JP2017537940A (ja) * 2014-12-10 2017-12-21 マサチューセッツ インスティテュート オブ テクノロジー 増殖性疾患の処置に有用な融合１，３−アゾール誘導体
EP4212532A3 (en) 2015-04-30 2023-09-27 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
US11180492B2 (en) 2016-01-15 2021-11-23 University Of Central Florida Research Foundation, Inc. Anti-parasitic compounds and uses thereof
WO2017143059A1 (en) 2016-02-16 2017-08-24 Massachusetts Institute Of Technology Max binders as myc modulators and uses thereof
US11203601B2 (en) 2017-04-05 2021-12-21 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837282T2 (de) * 1997-12-13 2007-11-08 Bristol-Myers Squibb Co. VERWENDUNG VON PYRAZOLO Ä 3,4-bÜ PYRIDIN ALS CYCLIN-ABHÄNGIGE KINASE HEMMER
CA2391291A1 (en) 1999-11-19 2001-05-25 Abbott Laboratories Tricyclic dihydropyrimidine potassium channel openers
MXPA02008615A (es) 2000-03-03 2003-04-14 Abbott Lab Abridores de canales de potasio de dihidropirazolona triciclica y dihidroisoxazolona triciclica.
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
WO2002062795A2 (en) 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) * 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
KR20060070486A (ko) * 2003-06-13 2006-06-23 젠타리스 게엠베하 포스파티딜이노시톨 3-키나제의 억제 활성을 갖는 화합물및 이의 사용 방법

Also Published As

Publication number Publication date
CN101243087B (zh) 2013-07-24
ECSP078062A (es) 2008-01-23
AU2006273692B2 (en) 2012-11-22
PL1746097T3 (pl) 2010-06-30
AU2006273692A1 (en) 2007-02-01
CY1109964T1 (el) 2014-09-10
UY29685A1 (es) 2007-02-28
PT1746097E (pt) 2010-04-15
ATE521611T1 (de) 2011-09-15
ZA200800542B (en) 2010-02-24
TNSN08020A1 (en) 2009-07-14
CR9663A (es) 2008-02-21
JP2013063987A (ja) 2013-04-11
IL188861A0 (en) 2008-04-13
PE20070212A1 (es) 2007-03-21
JP2009501778A (ja) 2009-01-22
AR054845A1 (es) 2007-07-18
HN2008000088A (es) 2011-05-31
MA29634B1 (fr) 2008-07-01
PE20100718A1 (es) 2010-10-20
ATE455115T1 (de) 2010-01-15
ES2339676T3 (es) 2010-05-24
KR101286796B1 (ko) 2013-07-17
BRPI0614002A2 (pt) 2011-03-01
EP1746097A1 (en) 2007-01-24
DOP2006000175A (es) 2007-03-31
WO2007012972A2 (en) 2007-02-01
TW200740812A (en) 2007-11-01
WO2007012972A3 (en) 2007-04-05
NO20080831L (no) 2008-04-03
CA2615700C (en) 2013-06-18
DK1746097T3 (da) 2010-05-25
UA98928C2 (ru) 2012-07-10
SI1746097T1 (sl) 2010-05-31
TWI386411B (zh) 2013-02-21
AU2006273692B8 (en) 2012-12-13
EA016815B1 (ru) 2012-07-30
EP1746097B1 (en) 2010-01-13
DE602005018911D1 (de) 2010-03-04
EP1910366A2 (en) 2008-04-16
CN101243087A (zh) 2008-08-13
CA2615700A1 (en) 2007-02-01
HRP20100195T1 (hr) 2010-05-31
EP1910366B1 (en) 2011-08-24
NZ592766A (en) 2012-12-21
KR20080026658A (ko) 2008-03-25
AU2006273692A8 (en) 2012-12-13
US8163768B2 (en) 2012-04-24
MY148617A (en) 2013-05-15
US20080261969A1 (en) 2008-10-23
RS51351B (en) 2011-02-28
MX2008000902A (es) 2008-03-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU