NO20080831L - 1,4-dihydropyridin-fuserte heterosykler, fremgangsmate for fremstilling av det samme, anvendelse og sammensetninger inneholdende dem - Google Patents

1,4-dihydropyridin-fuserte heterosykler, fremgangsmate for fremstilling av det samme, anvendelse og sammensetninger inneholdende dem

Info

Publication number
NO20080831L
NO20080831L NO20080831A NO20080831A NO20080831L NO 20080831 L NO20080831 L NO 20080831L NO 20080831 A NO20080831 A NO 20080831A NO 20080831 A NO20080831 A NO 20080831A NO 20080831 L NO20080831 L NO 20080831L
Authority
NO
Norway
Prior art keywords
dihydropyridine
preparing
same
compositions containing
fused heterocycles
Prior art date
Application number
NO20080831A
Other languages
English (en)
Inventor
Jacques Mauger
Serge Mignani
Odile Angouillant-Boniface
Anil Nair
Bruno Filoche-Romme
Kirsten Bjergarde
Nina Ma
Jean-Christophe Carry
Francois Clerc
Herve Minoux
Laurent Schio
Cecile Combeau
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20080831L publication Critical patent/NO20080831L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1,4-dihydropyridinsammensmeltede heterosykler med formel I, fremgangsmåte for fremstilling av samme, anvendelse og sammensetninger som inneholder dem. Oppfinnelsen angår substituerte dihydropyridin-sammensmeltede heterosykler anvendelige for behandling av kreftsykdom, særlig for å hindre kreftceller fra å dele seg. Disse forbindelsene virker som inhibitorer av Aurora A- og/eller B-kinaser.
NO20080831A 2005-07-20 2008-02-15 1,4-dihydropyridin-fuserte heterosykler, fremgangsmate for fremstilling av det samme, anvendelse og sammensetninger inneholdende dem NO20080831L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (en) 2005-07-20 2005-07-20 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
PCT/IB2006/002734 WO2007012972A2 (en) 2005-07-20 2006-07-18 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number Publication Date
NO20080831L true NO20080831L (no) 2008-04-03

Family

ID=35510894

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080831A NO20080831L (no) 2005-07-20 2008-02-15 1,4-dihydropyridin-fuserte heterosykler, fremgangsmate for fremstilling av det samme, anvendelse og sammensetninger inneholdende dem

Country Status (37)

Country Link
US (1) US8163768B2 (no)
EP (2) EP1746097B1 (no)
JP (2) JP2009501778A (no)
KR (1) KR101286796B1 (no)
CN (1) CN101243087B (no)
AR (1) AR054845A1 (no)
AT (2) ATE455115T1 (no)
AU (1) AU2006273692B8 (no)
BR (1) BRPI0614002A2 (no)
CA (1) CA2615700C (no)
CR (1) CR9663A (no)
CY (1) CY1109964T1 (no)
DE (1) DE602005018911D1 (no)
DK (1) DK1746097T3 (no)
DO (1) DOP2006000175A (no)
EA (1) EA016815B1 (no)
EC (1) ECSP078062A (no)
ES (1) ES2339676T3 (no)
HN (1) HN2008000088A (no)
HR (1) HRP20100195T1 (no)
IL (1) IL188861A0 (no)
MA (1) MA29634B1 (no)
MX (1) MX2008000902A (no)
MY (1) MY148617A (no)
NO (1) NO20080831L (no)
NZ (1) NZ592766A (no)
PE (2) PE20070212A1 (no)
PL (1) PL1746097T3 (no)
PT (1) PT1746097E (no)
RS (1) RS51351B (no)
SI (1) SI1746097T1 (no)
TN (1) TNSN08020A1 (no)
TW (1) TWI386411B (no)
UA (1) UA98928C2 (no)
UY (1) UY29685A1 (no)
WO (1) WO2007012972A2 (no)
ZA (1) ZA200800542B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
AU2013261128B2 (en) 2012-05-15 2015-11-12 Novartis Ag Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
EP2861576B1 (en) 2012-05-15 2018-01-10 Novartis AG Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
WO2013171641A1 (en) 2012-05-15 2013-11-21 Novartis Ag Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1
MY169377A (en) 2012-05-15 2019-03-26 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
CA2887701C (en) 2012-10-12 2020-12-15 The Broad Institute, Inc. Gsk3 inhibitors and methods of use thereof
JP2017537940A (ja) * 2014-12-10 2017-12-21 マサチューセッツ インスティテュート オブ テクノロジー 増殖性疾患の処置に有用な融合１，３−アゾール誘導体
EP4212532A3 (en) 2015-04-30 2023-09-27 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
US11180492B2 (en) 2016-01-15 2021-11-23 University Of Central Florida Research Foundation, Inc. Anti-parasitic compounds and uses thereof
WO2017143059A1 (en) 2016-02-16 2017-08-24 Massachusetts Institute Of Technology Max binders as myc modulators and uses thereof
US11203601B2 (en) 2017-04-05 2021-12-21 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
DE69837282T2 (de) * 1997-12-13 2007-11-08 Bristol-Myers Squibb Co. VERWENDUNG VON PYRAZOLO Ä 3,4-bÜ PYRIDIN ALS CYCLIN-ABHÄNGIGE KINASE HEMMER
CA2391291A1 (en) 1999-11-19 2001-05-25 Abbott Laboratories Tricyclic dihydropyrimidine potassium channel openers
MXPA02008615A (es) 2000-03-03 2003-04-14 Abbott Lab Abridores de canales de potasio de dihidropirazolona triciclica y dihidroisoxazolona triciclica.
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
WO2002062795A2 (en) 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) * 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
KR20060070486A (ko) * 2003-06-13 2006-06-23 젠타리스 게엠베하 포스파티딜이노시톨 3-키나제의 억제 활성을 갖는 화합물및 이의 사용 방법

Also Published As

Publication number Publication date
CN101243087B (zh) 2013-07-24
ECSP078062A (es) 2008-01-23
AU2006273692B2 (en) 2012-11-22
PL1746097T3 (pl) 2010-06-30
AU2006273692A1 (en) 2007-02-01
CY1109964T1 (el) 2014-09-10
UY29685A1 (es) 2007-02-28
PT1746097E (pt) 2010-04-15
ATE521611T1 (de) 2011-09-15
ZA200800542B (en) 2010-02-24
TNSN08020A1 (en) 2009-07-14
CR9663A (es) 2008-02-21
JP2013063987A (ja) 2013-04-11
IL188861A0 (en) 2008-04-13
PE20070212A1 (es) 2007-03-21
JP2009501778A (ja) 2009-01-22
AR054845A1 (es) 2007-07-18
HN2008000088A (es) 2011-05-31
MA29634B1 (fr) 2008-07-01
PE20100718A1 (es) 2010-10-20
ATE455115T1 (de) 2010-01-15
ES2339676T3 (es) 2010-05-24
KR101286796B1 (ko) 2013-07-17
BRPI0614002A2 (pt) 2011-03-01
EP1746097A1 (en) 2007-01-24
DOP2006000175A (es) 2007-03-31
WO2007012972A2 (en) 2007-02-01
TW200740812A (en) 2007-11-01
WO2007012972A3 (en) 2007-04-05
CA2615700C (en) 2013-06-18
DK1746097T3 (da) 2010-05-25
EA200800374A1 (ru) 2008-08-29
UA98928C2 (ru) 2012-07-10
SI1746097T1 (sl) 2010-05-31
TWI386411B (zh) 2013-02-21
AU2006273692B8 (en) 2012-12-13
EA016815B1 (ru) 2012-07-30
EP1746097B1 (en) 2010-01-13
DE602005018911D1 (de) 2010-03-04
EP1910366A2 (en) 2008-04-16
CN101243087A (zh) 2008-08-13
CA2615700A1 (en) 2007-02-01
HRP20100195T1 (hr) 2010-05-31
EP1910366B1 (en) 2011-08-24
NZ592766A (en) 2012-12-21
KR20080026658A (ko) 2008-03-25
AU2006273692A8 (en) 2012-12-13
US8163768B2 (en) 2012-04-24
MY148617A (en) 2013-05-15
US20080261969A1 (en) 2008-10-23
RS51351B (en) 2011-02-28
MX2008000902A (es) 2008-03-26

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