PE20070212A1 - Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen - Google Patents

Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen

Info

Publication number
PE20070212A1
PE20070212A1 PE2006000862A PE2006000862A PE20070212A1 PE 20070212 A1 PE20070212 A1 PE 20070212A1 PE 2006000862 A PE2006000862 A PE 2006000862A PE 2006000862 A PE2006000862 A PE 2006000862A PE 20070212 A1 PE20070212 A1 PE 20070212A1
Authority
PE
Peru
Prior art keywords
hexahydro
dihydropyridine
prepare
processes
same
Prior art date
Application number
PE2006000862A
Other languages
English (en)
Inventor
Jacques Mauger
Anil Nair
Bruno Filoche-Romme
Serge Mignani
Odile Angouillant-Bonfiace
Kirsten Bjergarde
Nina Ma
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PE20070212A1 publication Critical patent/PE20070212A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, METILO; R2 ES ARILO SUSTITUIDO, HETEROARILO SUSTITUIDO; R3 ES H, R4; X ES N, CR7; Y, Y' E Y'' SON CADA UNO CH2, C=O, O, S, NH, NR7, ENTRE OTROS; R4 Y R7 SON CADA UNO H, ALQUILO SUSTITUIDO, ALQUIL-ALQUENILO SUSTITUIDO, ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(4-HIDROXI-3-METIL-FENIL)-2,4,6,7,8,9-HEXAHIDRO-PIRAZOLO[3,4-b]-1,7-NAFTIRIDIN-5-ONA; 4-[5-(1H-BENCIMIDAZOL-2-ILSULFANIL)-FURAN-2-IL]-1,4,6,7,8,9-HEXAHIDRO-PIRAZOLO[3,4-b]QUINOLIN-5-ONA; 4-CLORO-N-[3-(5-OXO-2,4,6,7,8,9-HEXAHIDRO-PIRAZOLO[3,4-b]-1,7-NAFTIRIDIN-4-IL)-TIAZOL-2-IL]-BENZAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS ACTUAN COMO INHIBIDORES DE AURORA A Y/O B QUINASAS Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CANCEROSAS
PE2006000862A 2005-07-20 2006-07-18 Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen PE20070212A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (en) 2005-07-20 2005-07-20 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number Publication Date
PE20070212A1 true PE20070212A1 (es) 2007-03-21

Family

ID=35510894

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2006000862A PE20070212A1 (es) 2005-07-20 2006-07-18 Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen
PE2010000153A PE20100718A1 (es) 2005-07-20 2006-07-18 Derivados triciclicos de 1, 4-dihidropiridina [b, e]-condensados como inhibidores de aurora quinasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2010000153A PE20100718A1 (es) 2005-07-20 2006-07-18 Derivados triciclicos de 1, 4-dihidropiridina [b, e]-condensados como inhibidores de aurora quinasas

Country Status (37)

Country Link
US (1) US8163768B2 (es)
EP (2) EP1746097B1 (es)
JP (2) JP2009501778A (es)
KR (1) KR101286796B1 (es)
CN (1) CN101243087B (es)
AR (1) AR054845A1 (es)
AT (2) ATE455115T1 (es)
AU (1) AU2006273692B8 (es)
BR (1) BRPI0614002A2 (es)
CA (1) CA2615700C (es)
CR (1) CR9663A (es)
CY (1) CY1109964T1 (es)
DE (1) DE602005018911D1 (es)
DK (1) DK1746097T3 (es)
DO (1) DOP2006000175A (es)
EA (1) EA016815B1 (es)
EC (1) ECSP078062A (es)
ES (1) ES2339676T3 (es)
HN (1) HN2008000088A (es)
HR (1) HRP20100195T1 (es)
IL (1) IL188861A0 (es)
MA (1) MA29634B1 (es)
MX (1) MX2008000902A (es)
MY (1) MY148617A (es)
NO (1) NO20080831L (es)
NZ (1) NZ592766A (es)
PE (2) PE20070212A1 (es)
PL (1) PL1746097T3 (es)
PT (1) PT1746097E (es)
RS (1) RS51351B (es)
SI (1) SI1746097T1 (es)
TN (1) TNSN08020A1 (es)
TW (1) TWI386411B (es)
UA (1) UA98928C2 (es)
UY (1) UY29685A1 (es)
WO (1) WO2007012972A2 (es)
ZA (1) ZA200800542B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
MA37519B1 (fr) 2012-05-15 2017-03-31 Novartis Ag Composés et compositions pour inhiber l'activité d'abl1, abl2 et bcr-abl1
ES2670667T3 (es) 2012-05-15 2018-05-31 Novartis Ag Derivados de benzamida para inhibir la actividad de ABL1, ABL2 y BCR-ABL1
WO2013171642A1 (en) 2012-05-15 2013-11-21 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
WO2013171641A1 (en) 2012-05-15 2013-11-21 Novartis Ag Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1
RS58700B1 (sr) * 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
JP2017537940A (ja) * 2014-12-10 2017-12-21 マサチューセッツ インスティテュート オブ テクノロジー 増殖性疾患の処置に有用な融合１，３−アゾール誘導体
US11046692B2 (en) 2015-04-30 2021-06-29 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
WO2017124087A1 (en) 2016-01-15 2017-07-20 Memorial Sloan-Kettering Cancer Center Anti-parasitic compounds and uses thereof
KR20180107261A (ko) 2016-02-16 2018-10-01 메사추세츠 인스티튜트 오브 테크놀로지 Myc 조정제로서의 MAX 결합제 및 그의 용도
CA3058198A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU747705C (en) * 1997-12-13 2004-09-23 Bristol-Myers Squibb Company Use of pyrazolo (3,4-b) pyridine as cyclin dependent kinase inhibitors
JP2003529552A (ja) 1999-11-19 2003-10-07 アボット・ラボラトリーズ 三環性ジヒドロピリミジンカリウムチャンネル開口剤
EP1259510B1 (en) 2000-03-03 2004-06-02 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
EP1355909A2 (en) 2001-02-02 2003-10-29 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) * 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
BRPI0411364A (pt) * 2003-06-13 2006-07-25 Zentaris Gmbh compostos tendo atividade inibidora de fosfatidilinositol 3-cinase e métodos de uso dos mesmos

Also Published As

Publication number Publication date
DE602005018911D1 (de) 2010-03-04
EP1910366A2 (en) 2008-04-16
UA98928C2 (ru) 2012-07-10
PE20100718A1 (es) 2010-10-20
UY29685A1 (es) 2007-02-28
AU2006273692B2 (en) 2012-11-22
JP2013063987A (ja) 2013-04-11
ATE455115T1 (de) 2010-01-15
ZA200800542B (en) 2010-02-24
TNSN08020A1 (en) 2009-07-14
EP1746097A1 (en) 2007-01-24
HRP20100195T1 (hr) 2010-05-31
TWI386411B (zh) 2013-02-21
HN2008000088A (es) 2011-05-31
AU2006273692A8 (en) 2012-12-13
MY148617A (en) 2013-05-15
EP1910366B1 (en) 2011-08-24
EA016815B1 (ru) 2012-07-30
EA200800374A1 (ru) 2008-08-29
RS51351B (en) 2011-02-28
AR054845A1 (es) 2007-07-18
NZ592766A (en) 2012-12-21
CN101243087B (zh) 2013-07-24
ATE521611T1 (de) 2011-09-15
CA2615700C (en) 2013-06-18
US20080261969A1 (en) 2008-10-23
CY1109964T1 (el) 2014-09-10
KR20080026658A (ko) 2008-03-25
JP2009501778A (ja) 2009-01-22
PT1746097E (pt) 2010-04-15
DOP2006000175A (es) 2007-03-31
NO20080831L (no) 2008-04-03
KR101286796B1 (ko) 2013-07-17
CA2615700A1 (en) 2007-02-01
US8163768B2 (en) 2012-04-24
ES2339676T3 (es) 2010-05-24
PL1746097T3 (pl) 2010-06-30
SI1746097T1 (sl) 2010-05-31
MA29634B1 (fr) 2008-07-01
TW200740812A (en) 2007-11-01
CN101243087A (zh) 2008-08-13
EP1746097B1 (en) 2010-01-13
WO2007012972A2 (en) 2007-02-01
AU2006273692B8 (en) 2012-12-13
AU2006273692A1 (en) 2007-02-01
ECSP078062A (es) 2008-01-23
WO2007012972A3 (en) 2007-04-05
MX2008000902A (es) 2008-03-26
IL188861A0 (en) 2008-04-13
CR9663A (es) 2008-02-21
DK1746097T3 (da) 2010-05-25
BRPI0614002A2 (pt) 2011-03-01

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