ATE493404T1 - Azabicyclo-(3,1,0)-hexan-derivate als modulatoren von dopamin-d3-rezeptoren - Google Patents

Azabicyclo-(3,1,0)-hexan-derivate als modulatoren von dopamin-d3-rezeptoren

Info

Publication number
ATE493404T1
ATE493404T1 AT06791503T AT06791503T ATE493404T1 AT E493404 T1 ATE493404 T1 AT E493404T1 AT 06791503 T AT06791503 T AT 06791503T AT 06791503 T AT06791503 T AT 06791503T AT E493404 T1 ATE493404 T1 AT E493404T1
Authority
AT
Austria
Prior art keywords
group
4alkyl
haloc1
4alkoxy
4alkanoyl
Prior art date
Application number
AT06791503T
Other languages
English (en)
Inventor
Dieter Hamprecht
Caterina Mazzoni
Fabrizio Micheli
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE493404T1 publication Critical patent/ATE493404T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
AT06791503T 2005-04-15 2006-04-13 Azabicyclo-(3,1,0)-hexan-derivate als modulatoren von dopamin-d3-rezeptoren ATE493404T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0507680.7A GB0507680D0 (en) 2005-04-15 2005-04-15 Compounds
PCT/EP2006/003778 WO2006136223A1 (en) 2005-04-15 2006-04-13 Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors

Publications (1)

Publication Number Publication Date
ATE493404T1 true ATE493404T1 (de) 2011-01-15

Family

ID=34630768

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06791503T ATE493404T1 (de) 2005-04-15 2006-04-13 Azabicyclo-(3,1,0)-hexan-derivate als modulatoren von dopamin-d3-rezeptoren

Country Status (8)

Country Link
US (1) US7875643B2 (de)
EP (1) EP1871768B1 (de)
JP (1) JP5231992B2 (de)
AT (1) ATE493404T1 (de)
DE (1) DE602006019221D1 (de)
ES (1) ES2358445T3 (de)
GB (1) GB0507680D0 (de)
WO (1) WO2006136223A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2060570E (pt) * 2004-02-23 2012-05-07 Glaxo Group Ltd Derivados de azabiciclo(3.1.0)-hexano úteis como moduladores dos receptores d3 da dopamina
GB0507601D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507602D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
ATE484502T1 (de) * 2005-06-14 2010-10-15 Glaxo Group Ltd Neue verbindungen
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
KR20170005888A (ko) 2005-07-27 2017-01-16 뉴로반스, 인크. 신규 1-아릴-3-아자바이사이클로［3.1.0］헥산：제조 방법 및 신경 정신 질환 치료를 위한 용도
GB0517191D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517175D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
EP1919908B1 (de) * 2005-08-22 2010-11-10 Glaxo Group Limited Triazolderivate als modulatoren von dopamin-d3-rezeptoren
GB0517193D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Novel use
GB0517187D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US8163927B2 (en) * 2006-04-03 2012-04-24 Glaxo Group Limited Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors
WO2007113260A1 (en) * 2006-04-03 2007-10-11 Glaxo Group Limited Azabicyclo [3. 1. o] hexyl derivatives as modulators of dopamine d3 receptors
FR2953521B1 (fr) * 2009-12-09 2011-11-18 Servier Lab Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ739139A (en) 2015-08-05 2023-01-27 Indivior Uk Ltd Dopamine d3 receptor antagonists having a bicyclo moiety
WO2019146740A1 (ja) 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
AR022229A1 (es) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
GB0015562D0 (en) 2000-06-23 2000-08-16 Pfizer Ltd Heterocycles
ATE382617T1 (de) 2000-11-14 2008-01-15 Smithkline Beecham Plc Tetrahydrobenzazepin-derivate zur verwendung als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)
PT2060570E (pt) 2004-02-23 2012-05-07 Glaxo Group Ltd Derivados de azabiciclo(3.1.0)-hexano úteis como moduladores dos receptores d3 da dopamina
GB0507601D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
EP1919908B1 (de) * 2005-08-22 2010-11-10 Glaxo Group Limited Triazolderivate als modulatoren von dopamin-d3-rezeptoren

Also Published As

Publication number Publication date
JP5231992B2 (ja) 2013-07-10
US20080167357A1 (en) 2008-07-10
ES2358445T3 (es) 2011-05-10
EP1871768B1 (de) 2010-12-29
EP1871768A1 (de) 2008-01-02
US7875643B2 (en) 2011-01-25
JP2008535888A (ja) 2008-09-04
WO2006136223A1 (en) 2006-12-28
DE602006019221D1 (de) 2011-02-10
GB0507680D0 (en) 2005-05-25

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