AR072809A1 - Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende - Google Patents

Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende

Info

Publication number
AR072809A1
AR072809A1 ARP090102692A ARP090102692A AR072809A1 AR 072809 A1 AR072809 A1 AR 072809A1 AR P090102692 A ARP090102692 A AR P090102692A AR P090102692 A ARP090102692 A AR P090102692A AR 072809 A1 AR072809 A1 AR 072809A1
Authority
AR
Argentina
Prior art keywords
hydrogen
cyano
halogen
alkyl
halogenoalkoxy
Prior art date
Application number
ARP090102692A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR072809A1 publication Critical patent/AR072809A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compuesto de (3-piridinil-carbonil)-4-(fenilsulfonilpiperazina) de la Formula (1), o una de sus sales o N-oxido farmacéuticamente aceptable para uso en la terapia, en la que: m y n se seleccionan independientemente de 0, 1 y 2; cuando están presentes, cada R1 se selecciona independientemente de alquilo C1-4, alcoxi C1-4, cicloalquilo C3-6, ciano, NR1aR1b, y halogeno: R1a y R1b se seleccionan independientemente de hidrogeno, alquilo C1-4, cicloalquilo C3-6 y un heterociclilo de 4 a 6 miembros; o R1a y R1b junto con el átomo de nitrogeno al que están unidos forman un anillo heterocíclico de 4 a 6 miembros; cuando están presentes, cada R2 es alquilo C1-4 R3 es hidrogeno, halogeno, ciano, halogenoalquilo C1-4 o halogenoalcoxi C1-4; R4 es hidrogeno o alquilo C1-4; R5 es hidrogeno, halogeno, ciano, halogenoalquilo C1-4 o halogenoalcoxi C1-4 R6 es hidrogeno, halogeno, ciano, halogenoalquilo C1-4 o halogenoalcoxi C1-4 de modo que al menos 1 de R3, R4, R5 y R6 es un grupo distinto de hidrogeno. Uso de los compuestos en terapia para tratar enfermedades para las cuales es beneficioso el bloqueo de los canales de calcio Cav2.2, y composiciones farmacéuticas que contienen.
ARP090102692A 2008-07-17 2009-07-15 Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende AR072809A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0813142.7A GB0813142D0 (en) 2008-07-17 2008-07-17 Novel compounds

Publications (1)

Publication Number Publication Date
AR072809A1 true AR072809A1 (es) 2010-09-22

Family

ID=39737239

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102692A AR072809A1 (es) 2008-07-17 2009-07-15 Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende

Country Status (19)

Country Link
US (3) US8530478B2 (es)
EP (2) EP2346828B1 (es)
JP (2) JP5543966B2 (es)
KR (1) KR101599087B1 (es)
CN (1) CN102099337B (es)
AR (1) AR072809A1 (es)
AU (1) AU2009272762B2 (es)
BR (1) BRPI0916622A2 (es)
CA (1) CA2730471C (es)
EA (1) EA018621B1 (es)
ES (2) ES2396960T3 (es)
GB (1) GB0813142D0 (es)
IL (1) IL210446A (es)
MX (1) MX2011000600A (es)
PL (1) PL2300432T3 (es)
TW (1) TW201016677A (es)
UY (1) UY31990A (es)
WO (2) WO2010007072A1 (es)
ZA (1) ZA201100014B (es)

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Also Published As

Publication number Publication date
MX2011000600A (es) 2011-05-24
US8530478B2 (en) 2013-09-10
EA018621B1 (ru) 2013-09-30
CN102099337B (zh) 2013-08-21
EP2300432A1 (en) 2011-03-30
EP2346828A1 (en) 2011-07-27
GB0813142D0 (en) 2008-08-27
US20120302746A1 (en) 2012-11-29
ZA201100014B (en) 2011-09-28
KR101599087B1 (ko) 2016-03-02
US8288388B2 (en) 2012-10-16
BRPI0916622A2 (pt) 2019-04-09
WO2010007072A1 (en) 2010-01-21
WO2010007073A1 (en) 2010-01-21
JP5688850B2 (ja) 2015-03-25
JP2011528019A (ja) 2011-11-10
EA201170209A1 (ru) 2011-08-30
ES2396960T3 (es) 2013-03-01
EP2346828B1 (en) 2012-10-03
US20110130379A1 (en) 2011-06-02
JP2011528020A (ja) 2011-11-10
IL210446A (en) 2014-01-30
JP5543966B2 (ja) 2014-07-09
PL2300432T3 (pl) 2013-03-29
IL210446A0 (en) 2011-03-31
CA2730471A1 (en) 2010-01-21
AU2009272762B2 (en) 2013-08-15
CN102099337A (zh) 2011-06-15
TW201016677A (en) 2010-05-01
US20100022555A1 (en) 2010-01-28
CA2730471C (en) 2016-12-06
UY31990A (es) 2010-01-05
KR20110031199A (ko) 2011-03-24
EP2300432B1 (en) 2012-10-03
ES2396962T3 (es) 2013-03-01
AU2009272762A1 (en) 2010-01-21
US8536183B2 (en) 2013-09-17

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