AR072809A1 - Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende - Google Patents
Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR072809A1 AR072809A1 ARP090102692A ARP090102692A AR072809A1 AR 072809 A1 AR072809 A1 AR 072809A1 AR P090102692 A ARP090102692 A AR P090102692A AR P090102692 A ARP090102692 A AR P090102692A AR 072809 A1 AR072809 A1 AR 072809A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- cyano
- halogen
- alkyl
- halogenoalkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Compuesto de (3-piridinil-carbonil)-4-(fenilsulfonilpiperazina) de la Formula (1), o una de sus sales o N-oxido farmacéuticamente aceptable para uso en la terapia, en la que: m y n se seleccionan independientemente de 0, 1 y 2; cuando están presentes, cada R1 se selecciona independientemente de alquilo C1-4, alcoxi C1-4, cicloalquilo C3-6, ciano, NR1aR1b, y halogeno: R1a y R1b se seleccionan independientemente de hidrogeno, alquilo C1-4, cicloalquilo C3-6 y un heterociclilo de 4 a 6 miembros; o R1a y R1b junto con el átomo de nitrogeno al que están unidos forman un anillo heterocíclico de 4 a 6 miembros; cuando están presentes, cada R2 es alquilo C1-4 R3 es hidrogeno, halogeno, ciano, halogenoalquilo C1-4 o halogenoalcoxi C1-4; R4 es hidrogeno o alquilo C1-4; R5 es hidrogeno, halogeno, ciano, halogenoalquilo C1-4 o halogenoalcoxi C1-4 R6 es hidrogeno, halogeno, ciano, halogenoalquilo C1-4 o halogenoalcoxi C1-4 de modo que al menos 1 de R3, R4, R5 y R6 es un grupo distinto de hidrogeno. Uso de los compuestos en terapia para tratar enfermedades para las cuales es beneficioso el bloqueo de los canales de calcio Cav2.2, y composiciones farmacéuticas que contienen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0813142.7A GB0813142D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR072809A1 true AR072809A1 (es) | 2010-09-22 |
Family
ID=39737239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090102692A AR072809A1 (es) | 2008-07-17 | 2009-07-15 | Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende |
Country Status (19)
Country | Link |
---|---|
US (3) | US8530478B2 (es) |
EP (2) | EP2346828B1 (es) |
JP (2) | JP5543966B2 (es) |
KR (1) | KR101599087B1 (es) |
CN (1) | CN102099337B (es) |
AR (1) | AR072809A1 (es) |
AU (1) | AU2009272762B2 (es) |
BR (1) | BRPI0916622A2 (es) |
CA (1) | CA2730471C (es) |
EA (1) | EA018621B1 (es) |
ES (2) | ES2396960T3 (es) |
GB (1) | GB0813142D0 (es) |
IL (1) | IL210446A (es) |
MX (1) | MX2011000600A (es) |
PL (1) | PL2300432T3 (es) |
TW (1) | TW201016677A (es) |
UY (1) | UY31990A (es) |
WO (2) | WO2010007072A1 (es) |
ZA (1) | ZA201100014B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
GB201000685D0 (en) * | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
US8933132B2 (en) * | 2011-01-19 | 2015-01-13 | Convergence Pharmaceuticals Limited | Tricyclic substituted benzenesulfonamide piperazine derivatives as CAV2.2 calcium channel blockers |
SI2723710T1 (sl) | 2011-06-27 | 2016-11-30 | Newron Pharmaceuticals S.P.A. | Fluorirani arilalkilaminokarboksamidni derivati |
BR112016023926A2 (pt) * | 2014-04-14 | 2017-08-15 | Gruenenthal Gmbh | heterociclil sulfonas substituídas por aril |
KR20160144487A (ko) | 2014-04-14 | 2016-12-16 | 그뤼넨탈 게엠베하 | 헤테로아릴 치환된 헤테로사이클릴 설폰 |
GB201516183D0 (en) * | 2015-09-14 | 2015-10-28 | Calchan Ltd | Novel pharmaceutical composition |
TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
TW201718557A (zh) | 2015-10-08 | 2017-06-01 | 歌林達有限公司 | 經吡唑基取代之四氫吡喃基碸 |
AU2018260699B2 (en) * | 2017-04-26 | 2022-04-28 | Cavion, Inc. | Methods for improving memory and cognition and for treating memory and cognitive disorders |
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2008
- 2008-07-17 GB GBGB0813142.7A patent/GB0813142D0/en not_active Ceased
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2009
- 2009-07-15 AR ARP090102692A patent/AR072809A1/es unknown
- 2009-07-15 UY UY0001031990A patent/UY31990A/es unknown
- 2009-07-15 EA EA201170209A patent/EA018621B1/ru not_active IP Right Cessation
- 2009-07-15 PL PL09780587T patent/PL2300432T3/pl unknown
- 2009-07-15 WO PCT/EP2009/059011 patent/WO2010007072A1/en active Application Filing
- 2009-07-15 JP JP2011517911A patent/JP5543966B2/ja not_active Expired - Fee Related
- 2009-07-15 TW TW098123842A patent/TW201016677A/zh unknown
- 2009-07-15 JP JP2011517910A patent/JP5688850B2/ja not_active Expired - Fee Related
- 2009-07-15 CA CA2730471A patent/CA2730471C/en not_active Expired - Fee Related
- 2009-07-15 US US13/054,265 patent/US8530478B2/en not_active Expired - Fee Related
- 2009-07-15 WO PCT/EP2009/059012 patent/WO2010007073A1/en active Application Filing
- 2009-07-15 EP EP09780586A patent/EP2346828B1/en not_active Not-in-force
- 2009-07-15 MX MX2011000600A patent/MX2011000600A/es active IP Right Grant
- 2009-07-15 ES ES09780586T patent/ES2396960T3/es active Active
- 2009-07-15 US US12/503,125 patent/US8288388B2/en not_active Expired - Fee Related
- 2009-07-15 EP EP09780587A patent/EP2300432B1/en not_active Not-in-force
- 2009-07-15 ES ES09780587T patent/ES2396962T3/es active Active
- 2009-07-15 AU AU2009272762A patent/AU2009272762B2/en not_active Ceased
- 2009-07-15 CN CN200980127788XA patent/CN102099337B/zh not_active Expired - Fee Related
- 2009-07-15 BR BRPI0916622-0A patent/BRPI0916622A2/pt not_active IP Right Cessation
- 2009-07-15 KR KR1020117001109A patent/KR101599087B1/ko not_active IP Right Cessation
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2011
- 2011-01-03 ZA ZA2011/00014A patent/ZA201100014B/en unknown
- 2011-01-03 IL IL210446A patent/IL210446A/en not_active IP Right Cessation
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2012
- 2012-08-07 US US13/568,211 patent/US8536183B2/en not_active Expired - Fee Related
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