PE20061436A1 - Derivados de amida sustituida como inhibidores de proteina quinasa - Google Patents

Derivados de amida sustituida como inhibidores de proteina quinasa

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Publication number
PE20061436A1
PE20061436A1 PE2006000442A PE2006000442A PE20061436A1 PE 20061436 A1 PE20061436 A1 PE 20061436A1 PE 2006000442 A PE2006000442 A PE 2006000442A PE 2006000442 A PE2006000442 A PE 2006000442A PE 20061436 A1 PE20061436 A1 PE 20061436A1
Authority
PE
Peru
Prior art keywords
ona
phenyl
cr3r4
derivatives
protein kinase
Prior art date
Application number
PE2006000442A
Other languages
English (en)
Inventor
Tae-Seong Kim
David Bauer
Alessandro Boezio
Deborah Choquette
Angelo Noel D
Ingrid M Fellows
Russell Graceffa
Satoko Hirai
Kevin Yang
Ning Xi
Aaron C Siegmund
Philip Roveto
Michele Potashman
Mark H Norman
Longbin Liu
Matthew Lee
Daniel La
Jean-Christophe Harmange
Julie Germain
Celia Dominguez
Amico Derin C D
Shon Booker
Steven Bellon
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PE20061436A1 publication Critical patent/PE20061436A1/es

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Abstract

SE REFIERE A COMPUESTOS DE FORMULA: R-X-W-Y-R1, EN DONDE R ES a) O b); T ES FENILO O HETEROARILO DE 5 A 6 MIEMBROS; Z ES N O CR7; W ES FENILO, BENZOMORFOLINO, PIRIDILO, PIRIMIDILO, PIRIDAZINO, PIRAZINILO OPCIONALMENTE SUSTITUIDOS; Y ES -NRaC(=O)-(CR3R4)p-, NRa-(CR3R4)p-, -NRa-(CR3R4)p-C(=O)-, ENTRE OTROS; R1 ES 3-PIRROLIDINIL-2-ONA, 3-IMIDAZOLINIL-2-ONA, PIRAZOLIL-3-ONA, OXAZOLIDINIL-2-ONA, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON PREFERIDOS: N-(4-(6,7-DIMETOXIQUINOLIN-4-ILOXI)-3-FLUOROFENIL)-1-METIL-3-OXO-2-FENIL-5-(PIRIDIN-4-IL)-2,3-DIHIDRO-1H-PIRAZOL-4-CARBOXAMIDA, N-(5-(7-METOXIQUINOLIN-1-ILOXI)PIRIDIN-2-IL)-1-METIL-3-OXO-2-FENIL-5-(PIRROLIDIN-1-ILMETIL)-2,3-DIHIDRO-1H-PIRAZOL-4-CARBOXAMIDA, ENTRE OTROS. TAMBIEN SE REFEIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA QUINASA VEGFR/KDR Y/O c-MET, POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON ANGIOGENESIS, TAL COMO CANCER Y METASTASIS
PE2006000442A 2005-04-27 2006-04-27 Derivados de amida sustituida como inhibidores de proteina quinasa PE20061436A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67580505P 2005-04-27 2005-04-27

Publications (1)

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PE20061436A1 true PE20061436A1 (es) 2007-02-08

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PE2006000442A PE20061436A1 (es) 2005-04-27 2006-04-27 Derivados de amida sustituida como inhibidores de proteina quinasa

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US (3) US7858623B2 (es)
EP (1) EP1881976B1 (es)
JP (1) JP5463033B2 (es)
KR (1) KR20080004617A (es)
CN (1) CN101248059A (es)
AR (1) AR054262A1 (es)
AU (1) AU2006239216B2 (es)
BR (1) BRPI0608097A2 (es)
CA (1) CA2605680C (es)
CR (1) CR9475A (es)
CY (1) CY1113324T1 (es)
DK (1) DK1881976T3 (es)
EA (1) EA013231B1 (es)
ES (1) ES2396219T3 (es)
GT (1) GT200600181A (es)
HK (1) HK1116161A1 (es)
HN (1) HN2006016313A (es)
HR (1) HRP20121069T1 (es)
IL (1) IL186526A (es)
JO (1) JO2787B1 (es)
MX (1) MX2007013216A (es)
MY (1) MY177111A (es)
NO (1) NO20076093L (es)
NZ (1) NZ562595A (es)
PE (1) PE20061436A1 (es)
PL (1) PL1881976T3 (es)
PT (1) PT1881976E (es)
RS (1) RS52596B (es)
SI (1) SI1881976T1 (es)
TW (1) TWI378094B (es)
UA (1) UA93375C2 (es)
UY (1) UY29503A1 (es)
WO (1) WO2006116713A1 (es)
ZA (1) ZA200708775B (es)

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