ATE286896T1 - Substituierte bicyclische heteroaryl-verbindungen als integrin antagonisten - Google Patents
Substituierte bicyclische heteroaryl-verbindungen als integrin antagonistenInfo
- Publication number
- ATE286896T1 ATE286896T1 AT00919064T AT00919064T ATE286896T1 AT E286896 T1 ATE286896 T1 AT E286896T1 AT 00919064 T AT00919064 T AT 00919064T AT 00919064 T AT00919064 T AT 00919064T AT E286896 T1 ATE286896 T1 AT E286896T1
- Authority
- AT
- Austria
- Prior art keywords
- linkage
- optionally substituted
- direct bond
- compounds
- alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Semiconductor Integrated Circuits (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9908355.2A GB9908355D0 (en) | 1999-04-12 | 1999-04-12 | Chemical compounds |
| US14147099P | 1999-06-29 | 1999-06-29 | |
| PCT/GB2000/001393 WO2000061580A1 (en) | 1999-04-12 | 2000-04-12 | Substituted bicyclic heteroaryl compounds as integrin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE286896T1 true ATE286896T1 (de) | 2005-01-15 |
Family
ID=26315408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00919064T ATE286896T1 (de) | 1999-04-12 | 2000-04-12 | Substituierte bicyclische heteroaryl-verbindungen als integrin antagonisten |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6706738B2 (de) |
| EP (1) | EP1183254B1 (de) |
| KR (1) | KR20010110750A (de) |
| CN (1) | CN1350534A (de) |
| AT (1) | ATE286896T1 (de) |
| AU (1) | AU769554B2 (de) |
| BG (1) | BG106083A (de) |
| BR (1) | BR0010599A (de) |
| CA (1) | CA2369728A1 (de) |
| CZ (1) | CZ20013661A3 (de) |
| DE (1) | DE60017389T2 (de) |
| EE (1) | EE200100528A (de) |
| ES (1) | ES2231179T3 (de) |
| HK (1) | HK1044937A1 (de) |
| HR (1) | HRP20010732A2 (de) |
| HU (1) | HUP0200803A3 (de) |
| IL (2) | IL145748A0 (de) |
| MX (1) | MXPA01010231A (de) |
| NO (1) | NO20014951L (de) |
| NZ (1) | NZ514602A (de) |
| PL (1) | PL351433A1 (de) |
| SK (1) | SK14372001A3 (de) |
| TR (1) | TR200102959T2 (de) |
| WO (1) | WO2000061580A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157487B2 (en) | 2000-12-28 | 2007-01-02 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| IL164302A0 (en) * | 2002-03-29 | 2005-12-18 | Chiron Corp | Substituted benzazoles and use thereof as raf kinase inhibitors |
| JP4676884B2 (ja) | 2003-07-24 | 2011-04-27 | 第一三共株式会社 | シクロヘキサンカルボン酸類 |
| CN1933839A (zh) | 2004-01-23 | 2007-03-21 | 安进公司 | 化合物和使用方法 |
| CA2553433A1 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc. | Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer |
| CA2576170A1 (en) * | 2004-08-16 | 2006-03-02 | The Procter & Gamble Company | 2-(amino or substituted amino)-5, 6-substituted phenol compounds, dyeing compositions containing them, and use thereof |
| DE102004041137A1 (de) * | 2004-08-25 | 2006-03-02 | Wella Ag | o-Aminophenol-Derivate und diese Verbindungen enthaltende Färbemittel |
| US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| US7652009B2 (en) | 2004-11-30 | 2010-01-26 | Amgem Inc. | Substituted heterocycles and methods of use |
| US7514460B2 (en) | 2004-12-22 | 2009-04-07 | 4Sc Ag | Benzazole analogues and uses thereof |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| TWI387592B (zh) | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
| KR101464385B1 (ko) | 2006-04-19 | 2014-11-21 | 노파르티스 아게 | ６-ｏ-치환된 벤즈옥사졸 및 벤조티아졸 화합물, 및 ｃｓｆ-１ｒ 신호전달의 억제 방법 |
| US7931838B2 (en) * | 2006-08-31 | 2011-04-26 | Virginia Tech Intellectual Properties, Inc. | Method for making oriented single-walled carbon nanotube/polymer nano-composite membranes |
| JP5343082B2 (ja) * | 2007-10-29 | 2013-11-13 | アムジエン・インコーポレーテツド | ベンゾモルホリン誘導体および使用方法 |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| US8674113B2 (en) | 2010-12-10 | 2014-03-18 | Boehringer Ingelheim International Gmbh | Compounds |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| EP2968443B1 (de) | 2013-03-15 | 2021-09-29 | Protagonist Therapeutics, Inc. | Hepcidin-analoga und verwendungen davon |
| LT3143037T (lt) | 2014-05-16 | 2021-10-11 | Protagonist Therapeutics, Inc. | Alfa4beta7 integrino tioeterio peptidų antagonistaii |
| CN113563423A (zh) | 2014-07-17 | 2021-10-29 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
| EP3201217A4 (de) | 2014-10-01 | 2018-07-18 | Protagonist Therapeutics Inc. | Neuartige cyclische monomer- und dimerpeptide mit integrin-antagonisten-aktivität |
| US9809623B2 (en) | 2014-10-01 | 2017-11-07 | Protagonist Therapeutics, Inc. | α4β7 peptide monomer and dimer antagonists |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| WO2017117411A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| CN109195618A (zh) | 2016-03-23 | 2019-01-11 | 领导医疗有限公司 | 用于合成α4β7肽拮抗剂的方法 |
| US10278957B2 (en) | 2017-09-11 | 2019-05-07 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
| CA3089868A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| MX2022000397A (es) | 2019-07-10 | 2022-04-25 | Protagonist Therapeutics Inc | Inhibidores peptídicos del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias. |
| CR20220332A (es) | 2020-01-15 | 2022-11-28 | Janssen Biotech Inc | Inhibidores de péptidos del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias |
| WO2021146454A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| JP2023525047A (ja) | 2020-05-06 | 2023-06-14 | エイジャックス セラピューティクス， インコーポレイテッド | Ｊａｋ２阻害薬としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール |
| PE20240631A1 (es) | 2020-11-20 | 2024-03-26 | Janssen Pharmaceutica Nv | Composiciones de inhibidores peptidicos del receptor de interleucina-23 |
| TW202334139A (zh) | 2021-11-09 | 2023-09-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳氧基苯并咪唑及氮雜苯并咪唑 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2161373T3 (es) * | 1995-08-30 | 2001-12-01 | Searle & Co | Derivados de meta-guanidina, urea, tiourea o acido azaciclico-aminobenzoico como antagonistas de integrinas. |
| JP2002511462A (ja) * | 1998-04-10 | 2002-04-16 | ジー・ディー・サール・アンド・カンパニー | ビトロネクチンアンタゴニストとしてのヘテロ環式グリシルβ−アラニン誘導体 |
| DE60027700T2 (de) * | 1999-02-16 | 2007-05-03 | Aventis Pharma Ltd., West Malling | Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden |
-
2000
- 2000-04-12 IL IL14574800A patent/IL145748A0/xx active IP Right Grant
- 2000-04-12 PL PL00351433A patent/PL351433A1/xx not_active Application Discontinuation
- 2000-04-12 MX MXPA01010231A patent/MXPA01010231A/es unknown
- 2000-04-12 CA CA002369728A patent/CA2369728A1/en not_active Abandoned
- 2000-04-12 AT AT00919064T patent/ATE286896T1/de not_active IP Right Cessation
- 2000-04-12 CZ CZ20013661A patent/CZ20013661A3/cs unknown
- 2000-04-12 BR BR0010599-6A patent/BR0010599A/pt not_active Application Discontinuation
- 2000-04-12 SK SK1437-2001A patent/SK14372001A3/sk unknown
- 2000-04-12 KR KR1020017013055A patent/KR20010110750A/ko not_active Application Discontinuation
- 2000-04-12 NZ NZ514602A patent/NZ514602A/xx unknown
- 2000-04-12 AU AU39816/00A patent/AU769554B2/en not_active Expired
- 2000-04-12 CN CN00807512A patent/CN1350534A/zh active Pending
- 2000-04-12 DE DE60017389T patent/DE60017389T2/de not_active Expired - Lifetime
- 2000-04-12 ES ES00919064T patent/ES2231179T3/es not_active Expired - Lifetime
- 2000-04-12 TR TR2001/02959T patent/TR200102959T2/xx unknown
- 2000-04-12 EE EEP200100528A patent/EE200100528A/xx unknown
- 2000-04-12 HU HU0200803A patent/HUP0200803A3/hu unknown
- 2000-04-12 WO PCT/GB2000/001393 patent/WO2000061580A1/en not_active Application Discontinuation
- 2000-04-12 EP EP00919064A patent/EP1183254B1/de not_active Expired - Lifetime
-
2001
- 2001-10-04 IL IL145748A patent/IL145748A/en not_active IP Right Cessation
- 2001-10-10 HR HR20010732A patent/HRP20010732A2/hr not_active Application Discontinuation
- 2001-10-11 US US09/975,721 patent/US6706738B2/en not_active Expired - Lifetime
- 2001-10-11 NO NO20014951A patent/NO20014951L/no not_active Application Discontinuation
- 2001-11-05 BG BG106083A patent/BG106083A/xx unknown
-
2002
- 2002-07-30 HK HK02105579.6A patent/HK1044937A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20013661A3 (cs) | 2002-01-16 |
| EE200100528A (et) | 2003-02-17 |
| DE60017389T2 (de) | 2006-03-02 |
| KR20010110750A (ko) | 2001-12-13 |
| TR200102959T2 (tr) | 2002-04-22 |
| CA2369728A1 (en) | 2000-10-19 |
| HUP0200803A3 (en) | 2002-12-28 |
| AU769554B2 (en) | 2004-01-29 |
| NO20014951L (no) | 2001-12-11 |
| HRP20010732A2 (en) | 2002-12-31 |
| US20020173506A1 (en) | 2002-11-21 |
| ES2231179T3 (es) | 2005-05-16 |
| BR0010599A (pt) | 2002-02-13 |
| BG106083A (en) | 2002-05-31 |
| EP1183254B1 (de) | 2005-01-12 |
| MXPA01010231A (es) | 2003-07-21 |
| US6706738B2 (en) | 2004-03-16 |
| NZ514602A (en) | 2003-06-30 |
| NO20014951D0 (no) | 2001-10-11 |
| HUP0200803A2 (hu) | 2002-07-29 |
| EP1183254A1 (de) | 2002-03-06 |
| DE60017389D1 (de) | 2005-02-17 |
| IL145748A (en) | 2007-02-11 |
| WO2000061580A1 (en) | 2000-10-19 |
| SK14372001A3 (sk) | 2002-06-04 |
| IL145748A0 (en) | 2002-07-25 |
| HK1044937A1 (zh) | 2002-11-08 |
| CN1350534A (zh) | 2002-05-22 |
| AU3981600A (en) | 2000-11-14 |
| PL351433A1 (en) | 2003-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |