HK1044937A1 - 作為整聯蛋白拮抗物的取代的雙環雜芳基化合物 - Google Patents

作為整聯蛋白拮抗物的取代的雙環雜芳基化合物

Info

Publication number
HK1044937A1
HK1044937A1 HK02105579.6A HK02105579A HK1044937A1 HK 1044937 A1 HK1044937 A1 HK 1044937A1 HK 02105579 A HK02105579 A HK 02105579A HK 1044937 A1 HK1044937 A1 HK 1044937A1
Authority
HK
Hong Kong
Prior art keywords
linkage
optionally substituted
direct bond
compounds
alkylene
Prior art date
Application number
HK02105579.6A
Other languages
English (en)
Inventor
Edward Clark David
Robert Eastwood Paul
Victor Harris Neil
Mccarthy Clive
David Morley Andrew
Dennis Pickett Stephen
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9908355.2A external-priority patent/GB9908355D0/en
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of HK1044937A1 publication Critical patent/HK1044937A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
HK02105579.6A 1999-04-12 2002-07-30 作為整聯蛋白拮抗物的取代的雙環雜芳基化合物 HK1044937A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9908355.2A GB9908355D0 (en) 1999-04-12 1999-04-12 Chemical compounds
US14147099P 1999-06-29 1999-06-29
PCT/GB2000/001393 WO2000061580A1 (en) 1999-04-12 2000-04-12 Substituted bicyclic heteroaryl compounds as integrin antagonists

Publications (1)

Publication Number Publication Date
HK1044937A1 true HK1044937A1 (zh) 2002-11-08

Family

ID=26315408

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02105579.6A HK1044937A1 (zh) 1999-04-12 2002-07-30 作為整聯蛋白拮抗物的取代的雙環雜芳基化合物

Country Status (24)

Country Link
US (1) US6706738B2 (zh)
EP (1) EP1183254B1 (zh)
KR (1) KR20010110750A (zh)
CN (1) CN1350534A (zh)
AT (1) ATE286896T1 (zh)
AU (1) AU769554B2 (zh)
BG (1) BG106083A (zh)
BR (1) BR0010599A (zh)
CA (1) CA2369728A1 (zh)
CZ (1) CZ20013661A3 (zh)
DE (1) DE60017389T2 (zh)
EE (1) EE200100528A (zh)
ES (1) ES2231179T3 (zh)
HK (1) HK1044937A1 (zh)
HR (1) HRP20010732A2 (zh)
HU (1) HUP0200803A3 (zh)
IL (2) IL145748A0 (zh)
MX (1) MXPA01010231A (zh)
NO (1) NO20014951L (zh)
NZ (1) NZ514602A (zh)
PL (1) PL351433A1 (zh)
SK (1) SK14372001A3 (zh)
TR (1) TR200102959T2 (zh)
WO (1) WO2000061580A1 (zh)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156064A0 (en) 2000-12-28 2003-12-23 Daiichi Seiyaku Co Vla-4 inhibitors
ES2336094T3 (es) * 2002-03-29 2010-04-08 Novartis Vaccines And Diagnostics, Inc. Benzazoles sustituidos y uso de los mismos como inhibidores de quinasa raf.
EP1650205B1 (en) 2003-07-24 2012-04-25 Daiichi Sankyo Company, Limited Cyclohexanecarboxylic acid compound
AU2005207946A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
JP4932495B2 (ja) 2004-01-23 2012-05-16 アムゲン インコーポレイテッド 化合物及び使用方法
JP4551450B2 (ja) * 2004-08-16 2010-09-29 ザ プロクター アンド ギャンブル カンパニー ケラチン繊維用染色剤、前記ケラチン繊維用染色剤を含有する染色組成物、及びそれらの使用
DE102004041137A1 (de) * 2004-08-25 2006-03-02 Wella Ag o-Aminophenol-Derivate und diese Verbindungen enthaltende Färbemittel
US20070021612A1 (en) * 2004-11-04 2007-01-25 University Of Notre Dame Du Lac Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
JP2008521900A (ja) 2004-11-30 2008-06-26 アムジエン・インコーポレーテツド キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用
US7514460B2 (en) 2004-12-22 2009-04-07 4Sc Ag Benzazole analogues and uses thereof
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
BRPI0710540B1 (pt) * 2006-04-19 2022-04-12 Novartis Ag Compostos de benzoxazol e benzotiazol substituídos por 6-o, e composição farmacêutica
US7931838B2 (en) * 2006-08-31 2011-04-26 Virginia Tech Intellectual Properties, Inc. Method for making oriented single-walled carbon nanotube/polymer nano-composite membranes
EP2220078B1 (en) * 2007-10-29 2013-05-22 Amgen, Inc Benzomorpholine derivatives and methods of use
UY32138A (es) * 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) * 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
UY33779A (es) 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
US9273093B2 (en) 2012-10-11 2016-03-01 Protagonist Therapeutics, Inc. α4β7 peptide dimer antagonists
ES2901704T3 (es) 2013-03-15 2022-03-23 Protagonist Therapeutics Inc Análogos de hepcidina y usos de los mismos
EP3960754A3 (en) 2014-05-16 2022-07-06 Protagonist Therapeutics, Inc. Alpha4beta7 integrin thioether peptide antagonists
SG10201810154WA (en) 2014-07-17 2018-12-28 Protagonist Therapeutics Inc Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
US10301371B2 (en) 2014-10-01 2019-05-28 Protagonist Therapeutics, Inc. Cyclic monomer and dimer peptides having integrin antagonist activity
SG11201702553RA (en) 2014-10-01 2017-04-27 Protagonist Therapeutics Inc NOVEL α4β7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
CA3009834A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
CN115925790A (zh) 2016-03-23 2023-04-07 领导医疗有限公司 用于合成α4β7肽拮抗剂的方法
US10278957B2 (en) 2017-09-11 2019-05-07 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
WO2019157268A1 (en) 2018-02-08 2019-08-15 Protagonist Therapeutics, Inc. Conjugated hepcidin mimetics
KR20220044277A (ko) 2019-07-10 2022-04-07 프로타고니스트 테라퓨틱스, 인코포레이티드 인터루킨-23 수용체의 펩티드 억제제 및 염증성 질환을 치료하기 위한 이의 용도
JP7441955B2 (ja) 2020-01-15 2024-03-01 ヤンセン バイオテツク，インコーポレーテツド インターロイキン２３受容体のペプチド阻害剤および炎症性疾患を治療するためのその使用
US11691963B2 (en) 2020-05-06 2023-07-04 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
IL302996A (en) 2020-11-20 2023-07-01 Janssen Pharmaceutica Nv Compositions of peptide inhibitors of the interleukin-23 receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850221B1 (en) * 1995-08-30 2001-07-18 G.D. Searle & Co. Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists
NZ507292A (en) * 1998-04-10 2003-12-19 G Heterocyclic glycyl beta-alanine derivatives useful as vitronectin antagonists
PT1153017E (pt) * 1999-02-16 2006-07-31 Aventis Pharma Ltd Compostos biciclicos e sua utilizacao como ligandos do receptor de integrina

Also Published As

Publication number Publication date
ATE286896T1 (de) 2005-01-15
TR200102959T2 (tr) 2002-04-22
HUP0200803A2 (hu) 2002-07-29
DE60017389T2 (de) 2006-03-02
CZ20013661A3 (cs) 2002-01-16
HRP20010732A2 (en) 2002-12-31
ES2231179T3 (es) 2005-05-16
EP1183254B1 (en) 2005-01-12
AU3981600A (en) 2000-11-14
IL145748A (en) 2007-02-11
DE60017389D1 (de) 2005-02-17
MXPA01010231A (es) 2003-07-21
IL145748A0 (en) 2002-07-25
KR20010110750A (ko) 2001-12-13
US20020173506A1 (en) 2002-11-21
BG106083A (en) 2002-05-31
NO20014951L (no) 2001-12-11
CA2369728A1 (en) 2000-10-19
EP1183254A1 (en) 2002-03-06
PL351433A1 (en) 2003-04-22
US6706738B2 (en) 2004-03-16
AU769554B2 (en) 2004-01-29
NO20014951D0 (no) 2001-10-11
EE200100528A (et) 2003-02-17
SK14372001A3 (sk) 2002-06-04
BR0010599A (pt) 2002-02-13
CN1350534A (zh) 2002-05-22
WO2000061580A1 (en) 2000-10-19
NZ514602A (en) 2003-06-30
HUP0200803A3 (en) 2002-12-28

Similar Documents

Publication Publication Date Title
IL145748A0 (en) Substituted bicyclic heteroaryl compounds as integrin antagonists
ATE51621T1 (de) Bicyclische kondensierte n-(4-piperidinyl)-2imidazolamin-derivate.
MY135686A (en) Indole derivatives useful as histamine h3 antagonists
NO986055D0 (no) Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
DE69034103D1 (de) Imidazoalkensäure
ATE212991T1 (de) Thiazolidinedione- und oxazolidinedione-derivate mit antidiabetischen, hypolipidämischen und anti hypertensiven eigenschaften
DK1392306T3 (da) Substituerede tetrahydroisoquinoliner til anvendelse i behandlingen af inflammatoriske sygdomme
DE60027700D1 (de) Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden
ATE421958T1 (de) Substituierte bizyclische verbindungen
AU641952B2 (en) Substituted N-(imidazolyl)alkyl alanine derivatives
RS50109B (sr) Derivati 4-heterociklilsulfonamidil-6-metoksi-5-(2-metoksi- fenoksi)-2-piridil-piridimina, njihovo dobivanje i primena kao antagonisti endotelinskih receptora
DE69221634D1 (de) 5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten
AR002715A1 (es) Derivados de piperazina y piperazinona heterociclos substituidos particularmente utiles como antagonistas de los receptores de taquikinina,composicion farmaceutica que incluye uno de dichos derivados, uso de dichos compuestos en la preparacion de las composiciones y procedimiento para la preparacion de los derivados
YU71501A (sh) Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina
WO1993004059A1 (en) 4-acylaminoimidazole derivative
HUP0100540A2 (hu) Szubsztituált oximok mint neurokinin antagonisták