DE60027700D1 - Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden - Google Patents
Bicyclische verbindungen und ihre verwendung als integrinrezeptorligandenInfo
- Publication number
- DE60027700D1 DE60027700D1 DE60027700T DE60027700T DE60027700D1 DE 60027700 D1 DE60027700 D1 DE 60027700D1 DE 60027700 T DE60027700 T DE 60027700T DE 60027700 T DE60027700 T DE 60027700T DE 60027700 D1 DE60027700 D1 DE 60027700D1
- Authority
- DE
- Germany
- Prior art keywords
- optionally substituted
- compounds
- receptor ligands
- integrin receptor
- bicyclic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9903532 | 1999-02-16 | ||
GBGB9903532.1A GB9903532D0 (en) | 1999-02-16 | 1999-02-16 | Chemical compounds |
US14144599P | 1999-06-29 | 1999-06-29 | |
US141445P | 1999-06-29 | ||
PCT/GB2000/000553 WO2000049005A1 (en) | 1999-02-16 | 2000-02-16 | Bicyclic compounds and their use as integrin receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60027700D1 true DE60027700D1 (de) | 2006-06-08 |
DE60027700T2 DE60027700T2 (de) | 2007-05-03 |
Family
ID=26315145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60027700T Expired - Fee Related DE60027700T2 (de) | 1999-02-16 | 2000-02-16 | Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden |
Country Status (11)
Country | Link |
---|---|
US (1) | US6593354B2 (de) |
EP (1) | EP1153017B1 (de) |
JP (1) | JP2002537292A (de) |
AT (1) | ATE325105T1 (de) |
AU (1) | AU775208B2 (de) |
CA (1) | CA2362862A1 (de) |
DE (1) | DE60027700T2 (de) |
DK (1) | DK1153017T3 (de) |
ES (1) | ES2263447T3 (de) |
PT (1) | PT1153017E (de) |
WO (1) | WO2000049005A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9908355D0 (en) * | 1999-04-12 | 1999-06-09 | Rhone Poulenc Rorer Ltd | Chemical compounds |
BR0010599A (pt) * | 1999-04-12 | 2002-02-13 | Aventis Pharma Ltd | Compostos de heteroarila bicìclicos substituìdos como antagonistas de integrina |
GB0001346D0 (en) * | 2000-01-21 | 2000-03-08 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004686D0 (en) * | 2000-02-28 | 2000-04-19 | Aventis Pharma Ltd | Chemical compounds |
ATE524441T1 (de) | 2000-12-28 | 2011-09-15 | Daiichi Seiyaku Co | Vla-4-inhibitoren |
US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
ES2382806T3 (es) | 2003-07-24 | 2012-06-13 | Daiichi Sankyo Company, Limited | Compuesto ácido ciclohexanocarboxílico |
US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
DE10360745A1 (de) * | 2003-12-23 | 2005-07-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
BRPI0508098A (pt) * | 2004-02-27 | 2007-07-17 | Amgen Inc | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos |
DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
DE102006021878A1 (de) * | 2006-05-11 | 2007-11-15 | Sanofi-Aventis | Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
UY32138A (es) * | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
US8674113B2 (en) | 2010-12-10 | 2014-03-18 | Boehringer Ingelheim International Gmbh | Compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4025637A (en) | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2,5 OR 2,6 Disubstituted benzoxazoles |
US4100168A (en) | 1974-09-20 | 1978-07-11 | Lilly Industries Ltd. | 2,5 OR 2,6-Disubstituted benzoxazoles |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
ATE204857T1 (de) * | 1996-03-29 | 2001-09-15 | Searle & Co | Meta-substituierte phenylenderivate und ihre verwendung als alphavbeta3 intergrin-antagonisten oder inhibitoren |
JPH10330369A (ja) | 1997-04-04 | 1998-12-15 | Sumitomo Pharmaceut Co Ltd | 複素環化合物 |
GB9723789D0 (en) | 1997-11-12 | 1998-01-07 | Zeneca Ltd | Chemical compounds |
WO2000005223A2 (en) * | 1998-07-23 | 2000-02-03 | Astrazeneca Ab | Heterocyclic derivatives and their use as integrin inhibitors |
GB9916374D0 (en) * | 1998-07-23 | 1999-09-15 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-02-16 DE DE60027700T patent/DE60027700T2/de not_active Expired - Fee Related
- 2000-02-16 ES ES00903864T patent/ES2263447T3/es not_active Expired - Lifetime
- 2000-02-16 DK DK00903864T patent/DK1153017T3/da active
- 2000-02-16 PT PT00903864T patent/PT1153017E/pt unknown
- 2000-02-16 JP JP2000599745A patent/JP2002537292A/ja active Pending
- 2000-02-16 AU AU25617/00A patent/AU775208B2/en not_active Ceased
- 2000-02-16 AT AT00903864T patent/ATE325105T1/de not_active IP Right Cessation
- 2000-02-16 EP EP00903864A patent/EP1153017B1/de not_active Expired - Lifetime
- 2000-02-16 CA CA002362862A patent/CA2362862A1/en not_active Abandoned
- 2000-02-16 WO PCT/GB2000/000553 patent/WO2000049005A1/en active IP Right Grant
-
2001
- 2001-08-09 US US09/925,110 patent/US6593354B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1153017B1 (de) | 2006-05-03 |
ATE325105T1 (de) | 2006-06-15 |
DK1153017T3 (da) | 2006-07-17 |
CA2362862A1 (en) | 2000-08-24 |
DE60027700T2 (de) | 2007-05-03 |
JP2002537292A (ja) | 2002-11-05 |
EP1153017A1 (de) | 2001-11-14 |
WO2000049005A1 (en) | 2000-08-24 |
PT1153017E (pt) | 2006-07-31 |
AU775208B2 (en) | 2004-07-22 |
ES2263447T3 (es) | 2006-12-16 |
US6593354B2 (en) | 2003-07-15 |
US20020137782A1 (en) | 2002-09-26 |
AU2561700A (en) | 2000-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |
|
8339 | Ceased/non-payment of the annual fee |