YU71501A - Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina - Google Patents

Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina

Info

Publication number
YU71501A
YU71501A YU71501A YUP71501A YU71501A YU 71501 A YU71501 A YU 71501A YU 71501 A YU71501 A YU 71501A YU P71501 A YUP71501 A YU P71501A YU 71501 A YU71501 A YU 71501A
Authority
YU
Yugoslavia
Prior art keywords
linkage
optionally substituted
direct bond
compounds
alkylene
Prior art date
Application number
YU71501A
Other languages
English (en)
Inventor
David Edward Clark
Paul Robert Eastwood
Neil Victor Harris
Clive Mccarthy
Andrew David Morley
Stephen Dennis Pickett
Original Assignee
Aventis Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Limited filed Critical Aventis Pharma Limited
Publication of YU71501A publication Critical patent/YU71501A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ovaj pronalazak je usmeren ka fizioloski aktivnim jedinjenjima opste formule (I) R1Z1-Het-L1-Ar1-L2-Y, gde je Het opciono supstituisan, zasicen, delimicno zasicen ili potpuno nezasicen 8 do 10 clani biciklicni prsten koji sadrzi najmanje jedan heteroatom, koji se bira izmedju O, S ili N; R1 je opciono supstituisani aril, heteroaril, alkil, alkenil, alkinil, cikloalkil ili heterocikloalkil; Z1 predstavlja direktnu vezu ili alkilenski lanac, NR4, O ili S(O)n; L1 je -R5-R6- veza, gde je R5 alkilen, alkenilen ili alkinilen, a R6 je direktna veza, cikloalkilen, heterocikloalkilen, arilen, heteroarildiil, -C(=Z3)-NR4, -NR4-C(=Z3)-, -C(=O)-, -C(=NOR)-, -NR4-, -NR4-C(=O) -NR4-, SO2NR4, -NR4-SO2-, -O-C(=O)-, -NR4-C(=O)-O- ili -O-C(=O) -NR4-; L2 je direktna veza, opciono supstituisana alkilenska, alkenilenska, alkinilenska, cikloalkenilenska, cikloalkilenska, heteroarildiil, heterocikloalkilenska ili arilenska veza; -[C(O)-N(R9)-C(R4)R10)]P veza;-C(=O)- CH2-C)=O)- veza -R11-Z4-R11- veza; ili -L3-L4-L5- veza; i Y je karboksi ili kiseli bioizoster; i odgovarajuci N-oksidi i njihovi prolekovi; i farmaceutski prihvatljive soli i solvati (npr. hidrati) tih jedinjenja i njihovi N-oksidi i prolekovi; Ova jedinjenja imaju vredna farmaceutska svojstva, narocito sposobnlost regulacije interakcije VCAN-1 i fibronektina sa integrinom VLA-4 (α4ß1).
YU71501A 1999-04-12 2000-04-12 Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina YU71501A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9908355.2A GB9908355D0 (en) 1999-04-12 1999-04-12 Chemical compounds
US14147099P 1999-06-29 1999-06-29

Publications (1)

Publication Number Publication Date
YU71501A true YU71501A (sh) 2005-07-19

Family

ID=10851398

Family Applications (1)

Application Number Title Priority Date Filing Date
YU71501A YU71501A (sh) 1999-04-12 2000-04-12 Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina

Country Status (6)

Country Link
JP (1) JP4864206B2 (sh)
CR (1) CR6559A (sh)
EA (1) EA200101067A1 (sh)
GB (1) GB9908355D0 (sh)
YU (1) YU71501A (sh)
ZA (1) ZA200108302B (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006056830A (ja) * 2004-08-20 2006-03-02 Dai Ichi Seiyaku Co Ltd ２−アリールアミノベンゾオキサゾール誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU674553B2 (en) * 1992-10-14 1997-01-02 Merck & Co., Inc. Fibrinogen receptor antagonists
AU675689B2 (en) * 1992-12-01 1997-02-13 Merck & Co., Inc. Fibrinogen receptor antagonists
MX9801716A (es) * 1995-08-30 1998-05-31 Searle & Co Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
IL125033A0 (en) * 1995-12-29 1999-01-26 Smithkline Beecham Corp Vitronectin receptor antagonists
JP4373497B2 (ja) * 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
EP1007026A4 (en) * 1997-01-17 2002-08-07 Merck & Co Inc INTEGRIN ANTAGONISTS
NZ507292A (en) * 1998-04-10 2003-12-19 G Heterocyclic glycyl beta-alanine derivatives useful as vitronectin antagonists
DK1153017T3 (da) * 1999-02-16 2006-07-17 Aventis Pharma Ltd Bicykliske forbindelser og deres anvendelse som integrinreceptorligander
GB9910394D0 (en) * 1999-05-05 1999-07-07 Rhone Poulenc Rorer Ltd Chemical compounds

Also Published As

Publication number Publication date
JP4864206B2 (ja) 2012-02-01
ZA200108302B (en) 2003-03-26
EA200101067A1 (ru) 2002-04-25
JP2002541257A (ja) 2002-12-03
GB9908355D0 (en) 1999-06-09
CR6559A (es) 2008-11-25

Similar Documents

Publication Publication Date Title
BG106083A (en) Substituted bicyclic heteroaryl compounds as integrin antagonists
HUP9901079A2 (hu) 5- és 6-Tagú nitrogéntartalmú gyűrűs vegyületek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0105432A2 (hu) Integrin-antagonista hatású új bifenil és bifenil-analóg vegyületek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
PE106499A1 (es) Antagonistas del receptor ccr-3
ATE51621T1 (de) Bicyclische kondensierte n-(4-piperidinyl)-2imidazolamin-derivate.
ATE421958T1 (de) Substituierte bizyclische verbindungen
FI881985A (fi) Foerfarande foer framstaellning av terapeutiskt verkande (s,s,s)-isomerer av substituerade acylderivat av 1,2,3,4-tetrahydroisokinolin-3-karboxylsyror.
DE3766198D1 (de) Bizyklische aromatische verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE135687T1 (de) Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel
HUP0302962A2 (hu) Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
WO2000068223A8 (en) Ureas and their use as cell adhesion modulators
HUP0001494A2 (hu) 3-Fenoxi-, 3-dibenzo[a,d]cikloheptenil-oxi-, 3-dibenz[b,f]-[1,4]oxazepinil-oxi-1-amino-2-propanol-származékok és az ezeket tartalmazó gyógyszerkészítmények
MX9605156A (es) Inhibidor de angiogenesis.
BRPI0312882B8 (pt) derivados de pleuromutilina e composição farmacêutica
PT1153017E (pt) Compostos biciclicos e sua utilizacao como ligandos do receptor de integrina
NO892338L (no) Middel for insekt- og middbekjempelse.
YU71501A (sh) Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina
WO2000068195A3 (en) Substituted pyrrolidines as cell adhesion inhibitors
WO1993004059A1 (en) 4-acylaminoimidazole derivative
MX9603343A (es) Antagonistas del receptor endotelial, procedimiento para preparar dichos compuestos y preparaciones farmaceuticas que los contienen.
ES8307734A1 (es) "procedimiento de producir derivados amidicos".
NO922345L (no) Farmakologisk aktive amidkarboksylatderivater