MX9603343A - Antagonistas del receptor endotelial, procedimiento para preparar dichos compuestos y preparaciones farmaceuticas que los contienen. - Google Patents

Antagonistas del receptor endotelial, procedimiento para preparar dichos compuestos y preparaciones farmaceuticas que los contienen.

Info

Publication number
MX9603343A
MX9603343A MX9603343A MX9603343A MX9603343A MX 9603343 A MX9603343 A MX 9603343A MX 9603343 A MX9603343 A MX 9603343A MX 9603343 A MX9603343 A MX 9603343A MX 9603343 A MX9603343 A MX 9603343A
Authority
MX
Mexico
Prior art keywords
compounds
pharmaceutical preparations
preparations containing
prepare
receptor antagonists
Prior art date
Application number
MX9603343A
Other languages
English (en)
Inventor
Dieter Dorsch
Mathias Osswald
Werner Mederski
Claudia Wilm
Claus Jochem Schmitges
Maria Christadler
Original Assignee
Merck Patent Gmbh
Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Haftung filed Critical Merck Patent Gmbh
Publication of MX9603343A publication Critical patent/MX9603343A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El invento se refiere a los nuevos compuestos de formula (I); en la que R1, R2, R3 y X tienen los significados indicados en la reivindicacion 1, y a sus sales. También se refiere a un procedimiento para preparar dichos compuestos, a las preparaciones farmacéuticas que los contienen y al empleo de los mismos para combatir enfermedades, en particular la hipertonía y la insuficiencia cardíaca. Los nuevos compuestos del invento poseen propiedades antagonistas del receptor endotelial.
MX9603343A 1995-08-16 1996-08-13 Antagonistas del receptor endotelial, procedimiento para preparar dichos compuestos y preparaciones farmaceuticas que los contienen. MX9603343A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19530032A DE19530032A1 (de) 1995-08-16 1995-08-16 Endothelin-Rezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
MX9603343A true MX9603343A (es) 1997-03-29

Family

ID=7769557

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603343A MX9603343A (es) 1995-08-16 1996-08-13 Antagonistas del receptor endotelial, procedimiento para preparar dichos compuestos y preparaciones farmaceuticas que los contienen.

Country Status (17)

Country Link
US (1) US5821256A (es)
EP (1) EP0758650A1 (es)
JP (1) JPH0959273A (es)
KR (1) KR970010756A (es)
CN (1) CN1149583A (es)
AR (1) AR003286A1 (es)
AU (1) AU6200296A (es)
BR (1) BR9603432A (es)
CA (1) CA2183307A1 (es)
CZ (1) CZ240096A3 (es)
DE (1) DE19530032A1 (es)
HU (1) HUP9602253A3 (es)
MX (1) MX9603343A (es)
NO (1) NO963411L (es)
PL (1) PL315707A1 (es)
SK (1) SK100096A3 (es)
ZA (1) ZA966933B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602029D0 (en) * 1996-02-01 1996-04-03 Fujisawa Pharmaceutical Co New heterocyclic compounds
DE19710831A1 (de) * 1997-03-15 1998-09-17 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
AU2002251978B2 (en) * 2001-02-09 2007-07-19 Merck & Co., Inc. 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
EP1926989A4 (en) * 2005-08-12 2008-12-24 Uop Llc METHOD AND DEVICE FOR ACCELERATING SAMPLE ANALYSIS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07110833B2 (ja) * 1986-12-02 1995-11-29 株式会社トクヤマ α−置換フエニル酢酸誘導体
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
GB9115153D0 (en) * 1991-07-12 1991-08-28 Patel Bipin C M Sol-gel composition for producing glassy coatings
RU2125980C1 (ru) * 1991-11-05 1999-02-10 Смитклайн Бичам Корпорейшн Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
PT617001E (pt) * 1993-03-19 2000-06-30 Merck & Co Inc Derivados do acido fenoxifenilacetico
AU3642795A (en) * 1994-09-27 1996-04-19 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis

Also Published As

Publication number Publication date
HUP9602253A3 (en) 1999-06-28
CZ240096A3 (en) 1997-03-12
SK100096A3 (en) 1997-03-05
ZA966933B (en) 1997-02-19
AR003286A1 (es) 1998-07-08
PL315707A1 (en) 1997-02-17
AU6200296A (en) 1997-02-20
HU9602253D0 (en) 1996-10-28
BR9603432A (pt) 1998-05-12
KR970010756A (ko) 1997-03-27
CA2183307A1 (en) 1997-02-17
JPH0959273A (ja) 1997-03-04
EP0758650A1 (de) 1997-02-19
US5821256A (en) 1998-10-13
NO963411L (no) 1997-02-17
DE19530032A1 (de) 1997-02-20
NO963411D0 (no) 1996-08-15
CN1149583A (zh) 1997-05-14
HUP9602253A2 (en) 1997-12-29

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