MX9605156A - Inhibidor de angiogenesis. - Google Patents

Inhibidor de angiogenesis.

Info

Publication number
MX9605156A
MX9605156A MX9605156A MX9605156A MX9605156A MX 9605156 A MX9605156 A MX 9605156A MX 9605156 A MX9605156 A MX 9605156A MX 9605156 A MX9605156 A MX 9605156A MX 9605156 A MX9605156 A MX 9605156A
Authority
MX
Mexico
Prior art keywords
compound
optionally substituted
cysteine protease
aryl
formula
Prior art date
Application number
MX9605156A
Other languages
English (en)
Inventor
Chiho Fukiage
Mitsuyoshi Azuma
Inouejun
Masayuki Nakamura
Yuka Yoshida
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Publication of MX9605156A publication Critical patent/MX9605156A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un inhibidor de angiogénesis que consiste de un compuesto inhibidor de proteasa de cisteína. Como los compuestos inhibidores de proteasa de cisteína preferidos, pueden ser usados compuestos de ácido epoxisuccínico, compuestos de halohidruro péptido, compuestos inhibidores de calpaina, compuestos de la formula (I), y compuesto de la formula (VI). El inhibidor de angiogénesis de la presente invencion suprimir la nueva formacion de vasos sanguíneos en los tejidos vivientes, así que puede ser usada como un agente profiláctico o terapéutico superior de angiogénesis asociada con la cura de heridas, inflamacion, crecimiento de un tumor y similares; y angiogénesis como la que se observa en retinopatía diabética, retinopatía prematura, oclusion venosa retinal, degeneracion macular discoide senil y similares, así como para la prevencion de metástasis de tumores.
MX9605156A 1995-10-25 1996-10-24 Inhibidor de angiogenesis. MX9605156A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27748595 1995-10-25
JP24804696 1996-09-19

Publications (1)

Publication Number Publication Date
MX9605156A true MX9605156A (es) 1998-05-31

Family

ID=26538555

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605156A MX9605156A (es) 1995-10-25 1996-10-24 Inhibidor de angiogenesis.

Country Status (13)

Country Link
US (2) US6057290A (es)
EP (2) EP0927716B1 (es)
AR (1) AR004694A1 (es)
AT (3) ATE230275T1 (es)
AU (1) AU716495B2 (es)
BR (1) BR9605267A (es)
CA (1) CA2188817C (es)
DE (3) DE69625622T2 (es)
ES (2) ES2193615T3 (es)
HU (1) HUP9602943A3 (es)
MX (1) MX9605156A (es)
NO (1) NO964514L (es)
PL (1) PL316669A1 (es)

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CN1195343A (zh) * 1995-07-13 1998-10-07 千寿制药株式会社 哌啶衍生物及其用途
US6214800B1 (en) * 1995-10-25 2001-04-10 Senju Pharmaceutical Co., Ltd. Angiogenesis inhibitor
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
JP4336039B2 (ja) * 1997-09-04 2009-09-30 日本ケミファ株式会社 エポキシコハク酸アミド誘導体
US6015787A (en) * 1997-11-04 2000-01-18 New England Medical Center Hospitals, Inc. Cell-permeable protein inhibitors of calpain
DE69939075D1 (de) * 1998-03-05 2008-08-21 Senju Pharma Co Pharmazeutische Zusammenstellung zur Vorbeugung und Behandlung von mit Zellkrankheiten des Augenhintergrundes zusammenhängenden Krankheiten
KR20010041967A (ko) * 1998-03-20 2001-05-25 요시다 쇼지 뇌조직 장애를 예방 및 치료하기 위한 시스테인프로테아제 억제제 함유 약제학적 조성물
GB9819860D0 (en) * 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
WO2000038730A2 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia
AU3196300A (en) * 1999-03-26 2000-10-16 Shionogi & Co., Ltd. Carbocyclic sulfonamide derivatives
KR20010001270A (ko) * 1999-06-03 2001-01-05 복성해 혈관신생을 억제하는 새로운 이소쿠마린 유도체
WO2001026648A1 (fr) 1999-10-13 2001-04-19 Senju Pharmaceutical Co., Ltd. Preparation d'adhesif a usage ophtalmique pour l'absorption par voie percutanee
WO2001041757A1 (fr) * 1999-12-10 2001-06-14 Senju Pharmaceutical Co., Ltd. Composition pharmaceutique contenant de la cyclodextrine
US7572833B2 (en) * 2000-10-26 2009-08-11 Senju Pharmaceutical Co., Ltd. Drug composition comprising dipeptidyl aldehyde derivative
WO2002048096A1 (fr) * 2000-12-12 2002-06-20 Senju Pharmaceutical Co., Ltd. Derives d'hydrazone et utilisation de ceux-ci dans des medicaments
MXPA03011197A (es) * 2001-06-06 2004-02-26 Lilly Co Eli Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales.
US7115607B2 (en) * 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
WO2003078415A1 (fr) * 2002-03-15 2003-09-25 Senju Pharmaceutical Co., Ltd. Derive de l'hemiacetal cyclique et son utilisation
ES2348534T3 (es) * 2002-03-29 2010-12-09 Senju Pharmaceutical Co., Ltd. Derivador de hidroximordolinona y uso medicinal del mismo.
EP1354586A1 (en) * 2002-04-20 2003-10-22 Aventis Pharma Deutschland GmbH The use of hydroxpyridone-derivatives in wound healing
DE60330038D1 (de) * 2002-07-22 2009-12-24 Senju Pharma Co Neue alpha-ketoamidderivate und deren verwendung
GB0314262D0 (en) 2003-06-19 2003-07-23 Univ Nottingham Trent Novel compounds and methods of using the same
US7615556B2 (en) 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US20120065793A1 (en) 2010-02-25 2012-03-15 Kaji Mitsuru Demand and supply control apparatus, demand and supply control method, and program
JP5823484B2 (ja) 2010-07-14 2015-11-25 千寿製薬株式会社 α―ケトアミド誘導体固体分散体
GB201218084D0 (en) * 2012-10-09 2012-11-21 Univ Aston Novel compounds and methods for use in medicine
GB201220474D0 (en) * 2012-11-14 2012-12-26 Sagetis Biotech Sl Polypeptides
US20210145930A1 (en) * 2018-05-07 2021-05-20 NeuroTheranostics, Inc. Multiple layer article with interactive reinforcements linear ribbon fiber reinforcement for composite forms
US20240150396A1 (en) * 2021-03-03 2024-05-09 The Texas A&M University System Inhibitors of cysteine proteases

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JPS50137951A (es) 1974-04-27 1975-11-01
JPS5754157A (en) 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
JP2536754B2 (ja) * 1987-05-08 1996-09-18 日本ケミファ株式会社 ピペラジン誘導体
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
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CN1195343A (zh) * 1995-07-13 1998-10-07 千寿制药株式会社 哌啶衍生物及其用途
ATE377006T1 (de) 1995-11-28 2007-11-15 Cephalon Inc Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer

Also Published As

Publication number Publication date
ES2190139T3 (es) 2003-07-16
CA2188817A1 (en) 1997-04-26
DE69628050T2 (de) 2004-04-01
NO964514D0 (no) 1996-10-24
AU7038496A (en) 1997-05-01
DE69625575D1 (de) 2003-02-06
NO964514L (no) 1997-04-28
ATE230275T1 (de) 2003-01-15
DE69625622D1 (de) 2003-02-06
ATE239698T1 (de) 2003-05-15
DE69625575T2 (de) 2003-09-25
EP0771565B1 (en) 2003-01-02
EP0927716A1 (en) 1999-07-07
DE69625622T2 (de) 2003-08-14
ES2193615T3 (es) 2003-11-01
EP0771565A3 (en) 1998-11-04
EP0771565A2 (en) 1997-05-07
DE69628050D1 (de) 2003-06-12
US6551999B1 (en) 2003-04-22
BR9605267A (pt) 1998-07-21
CA2188817C (en) 2010-01-26
HUP9602943A2 (en) 1997-08-28
HUP9602943A3 (en) 1998-03-02
AU716495B2 (en) 2000-02-24
ATE230389T1 (de) 2003-01-15
AR004694A1 (es) 1999-03-10
EP0927716B1 (en) 2003-05-07
PL316669A1 (en) 1997-04-28
US6057290A (en) 2000-05-02

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