ATE239698T1 - Angiogenese hemmer - Google Patents

Angiogenese hemmer

Info

Publication number
ATE239698T1
ATE239698T1 AT99106760T AT99106760T ATE239698T1 AT E239698 T1 ATE239698 T1 AT E239698T1 AT 99106760 T AT99106760 T AT 99106760T AT 99106760 T AT99106760 T AT 99106760T AT E239698 T1 ATE239698 T1 AT E239698T1
Authority
AT
Austria
Prior art keywords
angiogenesis inhibitors
angiogenesis
inhibitors
Prior art date
Application number
AT99106760T
Other languages
English (en)
Inventor
Chiho Fukiage
Mitsuyoshi Azuma
Jun Rui Inoue
Masayuki Nakamura
Yuka Yoshida
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Application granted granted Critical
Publication of ATE239698T1 publication Critical patent/ATE239698T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99106760T 1995-10-25 1996-10-23 Angiogenese hemmer ATE239698T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27748595 1995-10-25
JP24804696 1996-09-19

Publications (1)

Publication Number Publication Date
ATE239698T1 true ATE239698T1 (de) 2003-05-15

Family

ID=26538555

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99102501T ATE230389T1 (de) 1995-10-25 1996-10-23 Angiogenese inhibitoren
AT96116994T ATE230275T1 (de) 1995-10-25 1996-10-23 Angiogense-inhibitor
AT99106760T ATE239698T1 (de) 1995-10-25 1996-10-23 Angiogenese hemmer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT99102501T ATE230389T1 (de) 1995-10-25 1996-10-23 Angiogenese inhibitoren
AT96116994T ATE230275T1 (de) 1995-10-25 1996-10-23 Angiogense-inhibitor

Country Status (13)

Country Link
US (2) US6057290A (de)
EP (2) EP0927716B1 (de)
AR (1) AR004694A1 (de)
AT (3) ATE230389T1 (de)
AU (1) AU716495B2 (de)
BR (1) BR9605267A (de)
CA (1) CA2188817C (de)
DE (3) DE69628050T2 (de)
ES (2) ES2193615T3 (de)
HU (1) HUP9602943A3 (de)
MX (1) MX9605156A (de)
NO (1) NO964514L (de)
PL (1) PL316669A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003060A1 (en) * 1995-07-13 1997-01-30 Senju Pharmaceutical Co., Ltd. Piperazine derivatives and use of the same
US6214800B1 (en) * 1995-10-25 2001-04-10 Senju Pharmaceutical Co., Ltd. Angiogenesis inhibitor
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
ATE241607T1 (de) * 1997-09-04 2003-06-15 Nippon Chemiphar Co Epoxybernsteinsäureamid-derivate
US6015787A (en) * 1997-11-04 2000-01-18 New England Medical Center Hospitals, Inc. Cell-permeable protein inhibitors of calpain
ATE296635T1 (de) 1998-03-05 2005-06-15 Senju Pharma Co Pharmazeutische zusammenstellung zur vorbeugung und behandlung von mit zellkrankheiten des augenhintergrundes zusammenhängenden krankheiten
CN1301173A (zh) 1998-03-20 2001-06-27 千寿制药株式会社 用于预防和治疗脑组织损伤的含有半胱氨酸蛋白酶抑制剂的药用组合物
GB9819860D0 (en) * 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
JP2002533422A (ja) 1998-12-23 2002-10-08 ジー・ディー・サール・アンド・カンパニー 新形成の治療における併用療法としてシクロオキシゲナーゼ−２阻害剤とインテグリン拮抗剤を使用する方法
WO2000058280A1 (en) * 1999-03-26 2000-10-05 Shionogi & Co., Ltd. Carbocyclic sulfonamide derivatives
KR20010001270A (ko) 1999-06-03 2001-01-05 복성해 혈관신생을 억제하는 새로운 이소쿠마린 유도체
WO2001026648A1 (en) 1999-10-13 2001-04-19 Senju Pharmaceutical Co., Ltd. Ophthalmic adhesive preparations for percutaneous absorption
AU1735001A (en) * 1999-12-10 2001-06-18 Senju Pharmaceutical Co., Ltd. Cyclodextrin-containing pharmaceutical composition
WO2002034252A1 (en) * 2000-10-26 2002-05-02 Senju Pharmaceutical Co., Ltd. Drug composition comprising dipeptydyl aldehyde derivative
JPWO2002048096A1 (ja) * 2000-12-12 2004-04-15 千寿製薬株式会社 ヒドラゾン誘導体およびその医薬用途
JP4167173B2 (ja) 2001-06-06 2008-10-15 イーライ リリー アンド カンパニー 抗腫瘍剤としての使用のためのベンゾイルスルホンアミドおよびスルホンベンズアミジン
US7115607B2 (en) * 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
CN1297548C (zh) * 2002-03-15 2007-01-31 千寿制药株式会社 环状半缩醛衍生物及其应用
WO2003082837A1 (en) 2002-03-29 2003-10-09 Senju Pharmaceutical Co., Ltd. Hydroxymorpholinone derivative and medicinal use thereof
EP1354586A1 (de) * 2002-04-20 2003-10-22 Aventis Pharma Deutschland GmbH Verwendung von Hydroxypyridon Derivaten zur Wundheilung
ES2332363T3 (es) 2002-07-22 2010-02-03 Senju Pharmaceutical Co., Ltd. Nuevos derivados de alfa-cetoamida y su uso.
GB0314262D0 (en) 2003-06-19 2003-07-23 Univ Nottingham Trent Novel compounds and methods of using the same
US7615556B2 (en) * 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
WO2011105070A1 (ja) 2010-02-25 2011-09-01 パナソニック株式会社 需給制御装置、需給制御方法、およびプログラム
WO2012008159A1 (en) 2010-07-14 2012-01-19 Senju Pharmaceutical Co., Ltd. Solid dispersion of alfa-ketoamide derivatives
GB201218084D0 (en) * 2012-10-09 2012-11-21 Univ Aston Novel compounds and methods for use in medicine
GB201220474D0 (en) * 2012-11-14 2012-12-26 Sagetis Biotech Sl Polypeptides
WO2019217410A1 (en) * 2018-05-07 2019-11-14 Neuro Theranostics, Inc. Compositions and methods for treating traumatic brain injury
WO2022187491A1 (en) * 2021-03-03 2022-09-09 The Texas A& M University System Inhibitors of cysteine proteases

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50137951A (de) 1974-04-27 1975-11-01
JPS5754157A (en) 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
JP2536754B2 (ja) * 1987-05-08 1996-09-18 日本ケミファ株式会社 ピペラジン誘導体
JP2701932B2 (ja) * 1989-04-10 1998-01-21 サントリー株式会社 タンパク質分解酵素阻害剤
US5510531A (en) 1989-04-10 1996-04-23 Suntory Limited Proteinase inhibitor
EP0395309B1 (de) * 1989-04-28 1995-12-27 Takara Shuzo Co. Ltd. Dem menschlichen Calpastatin ähnliches Polypeptid
JPH06506921A (ja) 1991-02-22 1994-08-04 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 置換α−アミノアルデヒドおよび誘導体
EP0504938A3 (en) * 1991-03-22 1993-04-14 Suntory Limited Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
JP2848232B2 (ja) 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
US5607831A (en) 1993-03-25 1997-03-04 The United States Of America As Represented By The Department Of Health And Human Services In vitro methods for assessing the susceptibility of HIV-1-infected individuals to cysteine protease-mediated activation-induced programmed cell death
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
JP3599287B2 (ja) * 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
EP0783489A1 (de) * 1994-09-27 1997-07-16 Takeda Chemical Industries, Ltd. Aldehydderivate als upsteine protease inhibitoren
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
EP0731107A1 (de) * 1995-02-13 1996-09-11 Takeda Chemical Industries, Ltd. Herstellung von Aldehyd-Derivaten
US5981491A (en) 1995-05-10 1999-11-09 Darwin Discovery Limited Peptidyl compounds and their therapeutic use
WO1997003060A1 (en) * 1995-07-13 1997-01-30 Senju Pharmaceutical Co., Ltd. Piperazine derivatives and use of the same
ES2293651T3 (es) 1995-11-28 2008-03-16 Cephalon, Inc. Inhibidores de cisteina y serina proteasas derivados de aminoacidos d.

Also Published As

Publication number Publication date
NO964514D0 (no) 1996-10-24
ES2193615T3 (es) 2003-11-01
DE69625575T2 (de) 2003-09-25
US6057290A (en) 2000-05-02
EP0771565A2 (de) 1997-05-07
ATE230389T1 (de) 2003-01-15
DE69628050D1 (de) 2003-06-12
BR9605267A (pt) 1998-07-21
EP0927716B1 (de) 2003-05-07
MX9605156A (es) 1998-05-31
PL316669A1 (en) 1997-04-28
AR004694A1 (es) 1999-03-10
ES2190139T3 (es) 2003-07-16
HUP9602943A3 (en) 1998-03-02
DE69625575D1 (de) 2003-02-06
EP0771565A3 (de) 1998-11-04
CA2188817C (en) 2010-01-26
NO964514L (no) 1997-04-28
EP0927716A1 (de) 1999-07-07
DE69625622D1 (de) 2003-02-06
EP0771565B1 (de) 2003-01-02
US6551999B1 (en) 2003-04-22
AU7038496A (en) 1997-05-01
CA2188817A1 (en) 1997-04-26
AU716495B2 (en) 2000-02-24
DE69625622T2 (de) 2003-08-14
ATE230275T1 (de) 2003-01-15
DE69628050T2 (de) 2004-04-01
HUP9602943A2 (en) 1997-08-28

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Legal Events

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