ATE473216T1 - Hydroxymorpholinonderivat und dessen medizinische verwendung - Google Patents

Hydroxymorpholinonderivat und dessen medizinische verwendung

Info

Publication number
ATE473216T1
ATE473216T1 AT03745432T AT03745432T ATE473216T1 AT E473216 T1 ATE473216 T1 AT E473216T1 AT 03745432 T AT03745432 T AT 03745432T AT 03745432 T AT03745432 T AT 03745432T AT E473216 T1 ATE473216 T1 AT E473216T1
Authority
AT
Austria
Prior art keywords
hydroxymorpholinone
derivative
calpain
medical use
derivatives
Prior art date
Application number
AT03745432T
Other languages
English (en)
Inventor
Masayuki Nakamura
Jun Inoue
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Application granted granted Critical
Publication of ATE473216T1 publication Critical patent/ATE473216T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03745432T 2002-03-29 2003-03-27 Hydroxymorpholinonderivat und dessen medizinische verwendung ATE473216T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002097186 2002-03-29
PCT/JP2003/003910 WO2003082837A1 (fr) 2002-03-29 2003-03-27 Derive de l'hydroxymorpholinone et ses utilisations medicales

Publications (1)

Publication Number Publication Date
ATE473216T1 true ATE473216T1 (de) 2010-07-15

Family

ID=28671859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03745432T ATE473216T1 (de) 2002-03-29 2003-03-27 Hydroxymorpholinonderivat und dessen medizinische verwendung

Country Status (10)

Country Link
US (1) US7223755B2 (de)
EP (1) EP1491537B1 (de)
JP (1) JP4520747B2 (de)
KR (1) KR101032006B1 (de)
CN (1) CN100422161C (de)
AT (1) ATE473216T1 (de)
AU (1) AU2003236180A1 (de)
DE (1) DE60333268D1 (de)
ES (1) ES2348534T3 (de)
WO (1) WO2003082837A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2121578T (lt) 2007-01-12 2016-11-25 Novartis Ag 5-bifenil-4-amino-2-metilpentano rūgšties gavimo būdas
AU2011295170B2 (en) 2010-08-23 2014-12-18 Novartis Ag Process for the preparation of intermediates for the manufacture of NEP inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0629229B2 (ja) * 1987-11-05 1994-04-20 サントリー株式会社 システインプロティナーゼ阻害剤
PL171704B1 (pl) * 1992-05-20 1997-06-30 Senju Pharma Co Sposób wytwarzania srodka farmaceutycznego do leczenia lub profilaktyki zacmy PL
JP2825172B2 (ja) 1992-07-10 1998-11-18 東京エレクトロン株式会社 減圧処理装置および減圧処理方法
ATE230275T1 (de) 1995-10-25 2003-01-15 Senju Pharma Co Angiogense-inhibitor
CA2274464C (en) * 1996-12-11 2007-01-02 Basf Aktiengesellschaft Ketobenzamides as calpain inhibitors
IL159125A0 (en) * 2001-06-01 2004-05-12 Axys Pharm Inc Novel compounds and compositions as cathepsin inhibitors

Also Published As

Publication number Publication date
DE60333268D1 (de) 2010-08-19
ES2348534T3 (es) 2010-12-09
CN1656084A (zh) 2005-08-17
KR20040095339A (ko) 2004-11-12
CN100422161C (zh) 2008-10-01
EP1491537A8 (de) 2005-03-30
EP1491537A4 (de) 2007-10-10
US7223755B2 (en) 2007-05-29
AU2003236180A1 (en) 2003-10-13
EP1491537B1 (de) 2010-07-07
JP4520747B2 (ja) 2010-08-11
WO2003082837A1 (fr) 2003-10-09
JPWO2003082837A1 (ja) 2005-08-04
KR101032006B1 (ko) 2011-05-02
US20050176704A1 (en) 2005-08-11
EP1491537A1 (de) 2004-12-29

Similar Documents

Publication Publication Date Title
ATE449090T1 (de) Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
ATE344033T1 (de) Vinylphenyl-derivate als glk-aktivatoren
ECSP066311A (es) Derivados de la piperazina y su uso como agentes terapéuticos
DK1288205T3 (da) Nye phenylalanin-derivater
NO20065904L (no) Terapeutiske forbindelser
EA200101166A1 (ru) Ингибиторы металлопротеаз
NO20061214L (no) 2,4-pyrimidindiaminer nyttige i behandling av neoplastiske sykdomme,r inflammatoriske forstyrrelser og immunsystemforstyrrelser
NO20060973L (no) Pyridylderivater og deres anvendelse som tempeutiske midler
MX2007003321A (es) Derivados heterociclicos y su uso como agentes terapeuticos.
CY1105621T1 (el) Νεα ετεροκυκλικα παραγωγα φθορογλυκοζιτου, φαρμακα που περιεχουν τις ενωσεις αυτες και η χρηση τους
NO20055977L (no) Nye benzimidazolderivater
UA84146C2 (ru) Амиды пирролопиридин-2-карбоновой кислоты как ингибиторы гликогенфосфорилазы, способ их получения, фармацевтическая композиция и их применение как терапевтических агентов для лечения заболеваний
DE602004028150D1 (de) Aminopyrazolderivate als gsk-3-inhibitoren
BRPI0418939A (pt) derivados de nicotinamida e sua utilização como agentes terapêuticos
ATE416157T1 (de) Inhibitoren von integrin alpha-v-beta-6
ATE424821T1 (de) Pyrrolopyridin-2-karbonsäureamide
DE60121461D1 (de) Kondensierte pyridoindolderivate
DE60329330D1 (de) Piperidin- und pyrrolidin-derivate alsantagonisten des histamin-h3-rezeptors
ATE507226T1 (de) 1,3,4-oxadiazol-2-one als ppar-delta-modulatoren und deren verwendung
ATE364044T1 (de) 5ht2c rezeptor agonisten zur behandlung von diabetes und fettleibigkeit
EA200602154A1 (ru) Пиридин-4-илэтинилимидазолы и -пиразолы как антагонисты рецептора mglu5
ATE473216T1 (de) Hydroxymorpholinonderivat und dessen medizinische verwendung
EA200501557A1 (ru) Новый способ синтеза (2s)-индолин-2-карбоновой кислоты и использование в синтезе периндоприла
CY1110613T1 (el) Υποκατεστημενες θειαζολες και η χρησιμοποιηση τους για την παρασκευη φαρμακων
ATE440835T1 (de) Heterozyklische harnstoff-derivate für die behandlung von schmerzen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties