DE69625575T2 - Angiogense-Inhibitor - Google Patents

Angiogense-Inhibitor

Info

Publication number
DE69625575T2
DE69625575T2 DE69625575T DE69625575T DE69625575T2 DE 69625575 T2 DE69625575 T2 DE 69625575T2 DE 69625575 T DE69625575 T DE 69625575T DE 69625575 T DE69625575 T DE 69625575T DE 69625575 T2 DE69625575 T2 DE 69625575T2
Authority
DE
Germany
Prior art keywords
angiogenesis inhibitor
angiogenesis
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69625575T
Other languages
English (en)
Other versions
DE69625575D1 (de
Inventor
Chiho Fukiage
Mitsuyoshi Azuma
Jun Inoue
Masayuki Nakamura
Yuka Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Publication of DE69625575D1 publication Critical patent/DE69625575D1/de
Application granted granted Critical
Publication of DE69625575T2 publication Critical patent/DE69625575T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69625575T 1995-10-25 1996-10-23 Angiogense-Inhibitor Expired - Lifetime DE69625575T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27748595 1995-10-25
JP24804696 1996-09-19

Publications (2)

Publication Number Publication Date
DE69625575D1 DE69625575D1 (de) 2003-02-06
DE69625575T2 true DE69625575T2 (de) 2003-09-25

Family

ID=26538555

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69625575T Expired - Lifetime DE69625575T2 (de) 1995-10-25 1996-10-23 Angiogense-Inhibitor
DE69625622T Expired - Lifetime DE69625622T2 (de) 1995-10-25 1996-10-23 Angiogenese Inhibitoren
DE69628050T Expired - Lifetime DE69628050T2 (de) 1995-10-25 1996-10-23 Angiogenese Hemmer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69625622T Expired - Lifetime DE69625622T2 (de) 1995-10-25 1996-10-23 Angiogenese Inhibitoren
DE69628050T Expired - Lifetime DE69628050T2 (de) 1995-10-25 1996-10-23 Angiogenese Hemmer

Country Status (13)

Country Link
US (2) US6057290A (de)
EP (2) EP0771565B1 (de)
AR (1) AR004694A1 (de)
AT (3) ATE230275T1 (de)
AU (1) AU716495B2 (de)
BR (1) BR9605267A (de)
CA (1) CA2188817C (de)
DE (3) DE69625575T2 (de)
ES (2) ES2190139T3 (de)
HU (1) HUP9602943A3 (de)
MX (1) MX9605156A (de)
NO (1) NO964514L (de)
PL (1) PL316669A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935959A (en) * 1995-07-13 1999-08-10 Senju Pharmaceutical Co., Ltd. Piperazine derivatives and use as cysteine inhibitors
US6214800B1 (en) * 1995-10-25 2001-04-10 Senju Pharmaceutical Co., Ltd. Angiogenesis inhibitor
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
JP4336039B2 (ja) * 1997-09-04 2009-09-30 日本ケミファ株式会社 エポキシコハク酸アミド誘導体
US6015787A (en) * 1997-11-04 2000-01-18 New England Medical Center Hospitals, Inc. Cell-permeable protein inhibitors of calpain
CA2322854A1 (en) * 1998-03-05 1999-09-10 Jun Inoue Pharmaceutical composition for prophylaxis and therapy of diseases associated with ocular fundus tissue cytopathy
DE69919995T2 (de) 1998-03-20 2005-09-22 Senju Pharmaceutical Co., Ltd. Verwendung von cysteinprotease inhibitoren zur herstellung eines arzneimittels zur vorgbeugung und behandlung von gehirngewebezerrütung infolge hypertensive enzephalopathie oder encephalothlipsis
GB9819860D0 (en) * 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
JP2002533416A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール ＆ カンパニー 新形成の治療における組み合わせ治療としてのシクロオキシゲナーゼ−２インヒビターおよび一つまたはそれ以上の抗腫瘍薬の使用方法
WO2000058280A1 (fr) * 1999-03-26 2000-10-05 Shionogi & Co., Ltd. Derives de sulfonamide carbocyclique
KR20010001270A (ko) 1999-06-03 2001-01-05 복성해 혈관신생을 억제하는 새로운 이소쿠마린 유도체
WO2001026648A1 (fr) 1999-10-13 2001-04-19 Senju Pharmaceutical Co., Ltd. Preparation d'adhesif a usage ophtalmique pour l'absorption par voie percutanee
AU1735001A (en) * 1999-12-10 2001-06-18 Senju Pharmaceutical Co., Ltd. Cyclodextrin-containing pharmaceutical composition
AU2001292287A1 (en) * 2000-10-26 2002-05-06 Senju Pharmaceutical Co. Ltd. Drug composition comprising dipeptydyl aldehyde derivative
WO2002048096A1 (fr) * 2000-12-12 2002-06-20 Senju Pharmaceutical Co., Ltd. Derives d'hydrazone et utilisation de ceux-ci dans des medicaments
JP4167173B2 (ja) 2001-06-06 2008-10-15 イーライ リリー アンド カンパニー 抗腫瘍剤としての使用のためのベンゾイルスルホンアミドおよびスルホンベンズアミジン
US7115607B2 (en) * 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
KR101016593B1 (ko) * 2002-03-15 2011-02-22 센주 세이야꾸 가부시키가이샤 환식 반아세탈 유도체 및 이의 용도
US7223755B2 (en) * 2002-03-29 2007-05-29 Senju Pharmaceutical Co., Ltd. Hydroxymorpholinone derivative and medicinal use thereof
EP1354586A1 (de) * 2002-04-20 2003-10-22 Aventis Pharma Deutschland GmbH Verwendung von Hydroxypyridon Derivaten zur Wundheilung
EP1557407B1 (de) 2002-07-22 2009-11-11 Senju Pharmaceutical Co., Ltd. Neue alpha-ketoamidderivate und deren verwendung
GB0314262D0 (en) 2003-06-19 2003-07-23 Univ Nottingham Trent Novel compounds and methods of using the same
US7615556B2 (en) * 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
JPWO2011105070A1 (ja) 2010-02-25 2013-06-20 パナソニック株式会社 需給制御装置、需給制御方法、およびプログラム
WO2012008159A1 (en) 2010-07-14 2012-01-19 Senju Pharmaceutical Co., Ltd. Solid dispersion of alfa-ketoamide derivatives
GB201218084D0 (en) 2012-10-09 2012-11-21 Univ Aston Novel compounds and methods for use in medicine
GB201220474D0 (en) * 2012-11-14 2012-12-26 Sagetis Biotech Sl Polypeptides
US20210145930A1 (en) * 2018-05-07 2021-05-20 NeuroTheranostics, Inc. Multiple layer article with interactive reinforcements linear ribbon fiber reinforcement for composite forms
US20240150396A1 (en) * 2021-03-03 2024-05-09 The Texas A&M University System Inhibitors of cysteine proteases

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50137951A (de) 1974-04-27 1975-11-01
JPS5754157A (en) 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
JP2536754B2 (ja) * 1987-05-08 1996-09-18 日本ケミファ株式会社 ピペラジン誘導体
US5510531A (en) 1989-04-10 1996-04-23 Suntory Limited Proteinase inhibitor
JP2701932B2 (ja) * 1989-04-10 1998-01-21 サントリー株式会社 タンパク質分解酵素阻害剤
EP0395309B1 (de) * 1989-04-28 1995-12-27 Takara Shuzo Co. Ltd. Dem menschlichen Calpastatin ähnliches Polypeptid
EP0572547A1 (de) 1991-02-22 1993-12-08 The Du Pont Merck Pharmaceutical Company Substituierte alpha-amino aldehyde und derivate
EP0504938A3 (en) * 1991-03-22 1993-04-14 Suntory Limited Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
JP2848232B2 (ja) 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
US5607831A (en) 1993-03-25 1997-03-04 The United States Of America As Represented By The Department Of Health And Human Services In vitro methods for assessing the susceptibility of HIV-1-infected individuals to cysteine protease-mediated activation-induced programmed cell death
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
JP3599287B2 (ja) * 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
WO1996010014A1 (en) * 1994-09-27 1996-04-04 Takeda Chemical Industries, Ltd. Aldehyde derivatives as upsteine protease inhibitors
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
EP0731107A1 (de) * 1995-02-13 1996-09-11 Takeda Chemical Industries, Ltd. Herstellung von Aldehyd-Derivaten
AU706064B2 (en) 1995-05-10 1999-06-10 Darwin Discovery Limited Peptide compounds which inhibit metalloproteinase and TNF liberation, and their therapeutic use
US5935959A (en) * 1995-07-13 1999-08-10 Senju Pharmaceutical Co., Ltd. Piperazine derivatives and use as cysteine inhibitors
JP2002515860A (ja) 1995-11-28 2002-05-28 セフアロン・インコーポレーテツド システイン及びセリンプロテアーゼのｄ―アミノ酸由来のインヒビター

Also Published As

Publication number Publication date
AU7038496A (en) 1997-05-01
NO964514L (no) 1997-04-28
ES2190139T3 (es) 2003-07-16
EP0771565B1 (de) 2003-01-02
DE69628050D1 (de) 2003-06-12
EP0927716A1 (de) 1999-07-07
HUP9602943A2 (en) 1997-08-28
DE69625575D1 (de) 2003-02-06
CA2188817C (en) 2010-01-26
CA2188817A1 (en) 1997-04-26
BR9605267A (pt) 1998-07-21
MX9605156A (es) 1998-05-31
ATE230275T1 (de) 2003-01-15
EP0771565A2 (de) 1997-05-07
US6057290A (en) 2000-05-02
DE69625622D1 (de) 2003-02-06
AR004694A1 (es) 1999-03-10
HUP9602943A3 (en) 1998-03-02
PL316669A1 (en) 1997-04-28
AU716495B2 (en) 2000-02-24
US6551999B1 (en) 2003-04-22
DE69628050T2 (de) 2004-04-01
EP0771565A3 (de) 1998-11-04
EP0927716B1 (de) 2003-05-07
ATE239698T1 (de) 2003-05-15
ATE230389T1 (de) 2003-01-15
DE69625622T2 (de) 2003-08-14
ES2193615T3 (es) 2003-11-01
NO964514D0 (no) 1996-10-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition