MXPA03011197A - Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales. - Google Patents

Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales.

Info

Publication number
MXPA03011197A
MXPA03011197A MXPA03011197A MXPA03011197A MXPA03011197A MX PA03011197 A MXPA03011197 A MX PA03011197A MX PA03011197 A MXPA03011197 A MX PA03011197A MX PA03011197 A MXPA03011197 A MX PA03011197A MX PA03011197 A MXPA03011197 A MX PA03011197A
Authority
MX
Mexico
Prior art keywords
sulfonylbenzamidines
benzoylsulfonamides
antitumour agents
antitumour
agents
Prior art date
Application number
MXPA03011197A
Other languages
English (en)
Inventor
Sue Grossman Cora
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MXPA03011197A publication Critical patent/MXPA03011197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms

Abstract

La presente invencion proporciona compuestos antitumorales de la formula (I) y metodos antitumorales. (ver formula).
MXPA03011197A 2001-06-06 2002-05-24 Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales. MXPA03011197A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29635001P 2001-06-06 2001-06-06
PCT/US2002/015142 WO2002098848A1 (en) 2001-06-06 2002-05-24 Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents

Publications (1)

Publication Number Publication Date
MXPA03011197A true MXPA03011197A (es) 2004-02-26

Family

ID=23141662

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011197A MXPA03011197A (es) 2001-06-06 2002-05-24 Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales.

Country Status (36)

Country Link
US (1) US7183320B2 (es)
EP (1) EP1401806B1 (es)
JP (1) JP4167173B2 (es)
KR (1) KR100880760B1 (es)
CN (1) CN100475787C (es)
AR (1) AR036079A1 (es)
AT (1) ATE335722T1 (es)
AU (1) AU2002259204B2 (es)
BR (1) BR0210078A (es)
CA (1) CA2446719A1 (es)
CR (1) CR7182A (es)
CY (1) CY1105386T1 (es)
CZ (1) CZ20033296A3 (es)
DE (1) DE60213810T2 (es)
DK (1) DK1401806T3 (es)
EA (1) EA005810B1 (es)
EC (1) ECSP034874A (es)
EG (1) EG24356A (es)
ES (1) ES2269688T3 (es)
HK (1) HK1064360A1 (es)
HR (1) HRP20031000A2 (es)
HU (1) HUP0400114A3 (es)
IL (1) IL158985A0 (es)
MX (1) MXPA03011197A (es)
MY (1) MY136855A (es)
NO (1) NO20035366L (es)
NZ (1) NZ529098A (es)
PE (1) PE20030199A1 (es)
PL (1) PL367188A1 (es)
PT (1) PT1401806E (es)
SK (1) SK14642003A3 (es)
SV (1) SV2003001076A (es)
TW (1) TWI266761B (es)
UA (1) UA74889C2 (es)
WO (1) WO2002098848A1 (es)
ZA (1) ZA200308644B (es)

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US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
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US7939532B2 (en) 2006-10-26 2011-05-10 Hoffmann-La Roche Inc. Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
US7879884B2 (en) 2007-05-16 2011-02-01 Hoffmann-La Roche Inc. Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
US20100160322A1 (en) * 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
SG193849A1 (en) * 2009-01-19 2013-10-30 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP2012136435A (ja) * 2009-03-30 2012-07-19 Eisai R & D Management Co Ltd 腫瘍組織の感受性を検査する方法
KR200457823Y1 (ko) * 2009-05-08 2012-01-05 황정용 쭈꾸미 포획용 어구
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
AR076705A1 (es) 2009-05-26 2011-06-29 Abbott Lab Agentes inductores de la apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
CN102947283B (zh) * 2010-03-25 2015-10-07 Abbvie公司 用于治疗癌症和免疫以及自身免疫性疾病的细胞凋亡诱导剂
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
ES2699205T3 (es) 2010-10-29 2019-02-07 Abbvie Inc Dispersiones sólidas que contienen un agente que induce la apoptosis
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HUE031267T2 (en) 2010-11-23 2017-06-28 Abbvie Ireland Unlimited Co Methods of treatment using selective BCL-2 inhibitors
CN103159649B (zh) * 2011-12-19 2016-03-09 天津市国际生物医药联合研究院 磺酰胺类化合物的制备及其应用
CN103159650B (zh) * 2011-12-19 2016-04-20 天津市国际生物医药联合研究院 芳香杂环磺酰胺类化合物的制备及其应用
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CN105712925B (zh) * 2014-12-05 2019-01-04 沈阳中化农药化工研发有限公司 一种取代的磺酰胺基(硫代)羰基化合物及其用途
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Also Published As

Publication number Publication date
MY136855A (en) 2008-11-28
ZA200308644B (en) 2005-02-07
EA200400006A1 (ru) 2004-06-24
EP1401806B1 (en) 2006-08-09
JP4167173B2 (ja) 2008-10-15
AU2002259204B2 (en) 2008-01-17
ATE335722T1 (de) 2006-09-15
NO20035366L (no) 2004-02-06
EA005810B1 (ru) 2005-06-30
AR036079A1 (es) 2004-08-11
ES2269688T3 (es) 2007-04-01
HUP0400114A3 (en) 2007-05-02
NO20035366D0 (no) 2003-12-02
EG24356A (en) 2009-03-04
UA74889C2 (en) 2006-02-15
BR0210078A (pt) 2004-06-22
PE20030199A1 (es) 2003-03-12
JP2004530709A (ja) 2004-10-07
US7183320B2 (en) 2007-02-27
CN100475787C (zh) 2009-04-08
SK14642003A3 (sk) 2004-12-01
DE60213810D1 (de) 2006-09-21
KR100880760B1 (ko) 2009-02-02
SV2003001076A (es) 2003-07-29
CA2446719A1 (en) 2002-12-12
CY1105386T1 (el) 2010-04-28
KR20040007656A (ko) 2004-01-24
HRP20031000A2 (en) 2004-04-30
PT1401806E (pt) 2006-11-30
IL158985A0 (en) 2004-05-12
TWI266761B (en) 2006-11-21
NZ529098A (en) 2005-08-26
EP1401806A1 (en) 2004-03-31
WO2002098848A1 (en) 2002-12-12
HUP0400114A2 (hu) 2005-04-28
PL367188A1 (en) 2005-02-21
CN1514824A (zh) 2004-07-21
HK1064360A1 (en) 2005-01-28
DE60213810T2 (de) 2007-02-01
CR7182A (es) 2004-06-08
ECSP034874A (es) 2004-01-28
DK1401806T3 (da) 2006-11-27
CZ20033296A3 (cs) 2004-04-14
US20040157741A1 (en) 2004-08-12

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