DE69034103D1 - Imidazoalkensäure - Google Patents

Imidazoalkensäure

Info

Publication number
DE69034103D1
DE69034103D1 DE69034103T DE69034103T DE69034103D1 DE 69034103 D1 DE69034103 D1 DE 69034103D1 DE 69034103 T DE69034103 T DE 69034103T DE 69034103 T DE69034103 T DE 69034103T DE 69034103 D1 DE69034103 D1 DE 69034103D1
Authority
DE
Germany
Prior art keywords
angiotensin
antagonists
imidazoalkensäure
receptor
glaucoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69034103T
Other languages
English (en)
Other versions
DE69034103T2 (de
Inventor
Joseph Alan Finkelstein
Richard Mcculloch Keenan
Joseph Weinstock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE69034103D1 publication Critical patent/DE69034103D1/de
Application granted granted Critical
Publication of DE69034103T2 publication Critical patent/DE69034103T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DE69034103T 1989-06-14 1990-06-07 Imidazoalkensäure Expired - Lifetime DE69034103T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36607989A 1989-06-14 1989-06-14
US50641290A 1990-04-06 1990-04-06
US366079 1990-04-06
US506412 1990-04-06

Publications (2)

Publication Number Publication Date
DE69034103D1 true DE69034103D1 (de) 2003-10-30
DE69034103T2 DE69034103T2 (de) 2004-07-15

Family

ID=27003220

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69034103T Expired - Lifetime DE69034103T2 (de) 1989-06-14 1990-06-07 Imidazoalkensäure
DE69033469T Expired - Lifetime DE69033469T2 (de) 1989-06-14 1990-06-07 Imidazoalkensäure
DE2000175018 Active DE10075018I2 (de) 1989-06-14 1990-06-07 Imidazoalkensäure.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69033469T Expired - Lifetime DE69033469T2 (de) 1989-06-14 1990-06-07 Imidazoalkensäure
DE2000175018 Active DE10075018I2 (de) 1989-06-14 1990-06-07 Imidazoalkensäure.

Country Status (26)

Country Link
EP (2) EP0955294B1 (de)
JP (1) JPH0768223B2 (de)
KR (1) KR0165837B1 (de)
CN (2) CN1027504C (de)
AT (2) ATE190051T1 (de)
CA (1) CA2018438C (de)
CY (1) CY2232B1 (de)
DE (3) DE69034103T2 (de)
DK (2) DK0403159T3 (de)
ES (2) ES2142789T3 (de)
FI (1) FI102610B1 (de)
GR (1) GR3033452T3 (de)
HK (2) HK1025315A1 (de)
HU (1) HU208537B (de)
IE (2) IE902140A1 (de)
IL (1) IL94698A (de)
LU (1) LU90562I2 (de)
MA (1) MA21896A1 (de)
NL (1) NL300006I2 (de)
NO (1) NO175977C (de)
NZ (1) NZ233997A (de)
PH (1) PH27592A (de)
PL (3) PL166669B1 (de)
PT (1) PT94377B (de)
SG (1) SG52330A1 (de)
ZW (1) ZW9490A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
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PL166722B1 (pl) 1995-06-30
PT94377B (pt) 1997-02-28
HU903847D0 (en) 1990-11-28
KR0165837B1 (ko) 1999-02-18
EP0955294A2 (de) 1999-11-10
AU633322B2 (en) 1993-01-28
AU5690190A (en) 1991-01-10
NZ233997A (en) 1991-04-26
IE902140L (en) 1990-12-14
FI102610B (fi) 1999-01-15
ES2207091T3 (es) 2004-05-16
CA2018438A1 (en) 1990-12-14
NO902632D0 (no) 1990-06-13
IE902140A1 (en) 1991-01-02
DE10075018I2 (de) 2001-08-09
DE10075018I1 (de) 2000-09-21
HK1025315A1 (en) 2000-11-10
EP0403159B1 (de) 2000-03-01
NO902632L (no) 1990-12-17
NO175977B (no) 1994-10-03
NO175977C (no) 1995-01-11
NL300006I1 (nl) 2000-07-03
CN1048038A (zh) 1990-12-26
PL165609B1 (pl) 1995-01-31
EP0403159A3 (de) 1991-12-27
DE69033469T2 (de) 2000-09-07
EP0955294B1 (de) 2003-09-24
JPH03115278A (ja) 1991-05-16
CN1027504C (zh) 1995-01-25
CN1079649A (zh) 1993-12-22
KR910000658A (ko) 1991-01-29
ATE190051T1 (de) 2000-03-15
EP0403159A2 (de) 1990-12-19
ZW9490A1 (en) 1990-10-31
CY2232B1 (en) 2003-04-18
IL94698A (en) 1994-07-31
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PT94377A (pt) 1991-03-20
ATE250587T1 (de) 2003-10-15
FI102610B1 (fi) 1999-01-15
CA2018438C (en) 2000-08-08
PL166669B1 (pl) 1995-06-30
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HUT55011A (en) 1991-04-29
PL285591A1 (en) 1991-03-25
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HU208537B (en) 1993-11-29
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CN1048159C (zh) 2000-01-12
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DK0403159T3 (da) 2000-08-14
SG52330A1 (en) 1998-09-28
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IL94698A0 (en) 1991-04-15
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