DE69221634T2 - 5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten - Google Patents

5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten

Info

Publication number
DE69221634T2
DE69221634T2 DE69221634T DE69221634T DE69221634T2 DE 69221634 T2 DE69221634 T2 DE 69221634T2 DE 69221634 T DE69221634 T DE 69221634T DE 69221634 T DE69221634 T DE 69221634T DE 69221634 T2 DE69221634 T2 DE 69221634T2
Authority
DE
Germany
Prior art keywords
optionally substituted
hydrogen
benzothiazepinone
piperazinylalkyl
usable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69221634T
Other languages
English (en)
Other versions
DE69221634D1 (de
Inventor
Teruo Yamamori
Horoshi Harada
Katsunori Sakai
Kazumi Iwaki
Kazuki Matsunaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69221634D1 publication Critical patent/DE69221634D1/de
Application granted granted Critical
Publication of DE69221634T2 publication Critical patent/DE69221634T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69221634T 1991-10-21 1992-10-16 5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten Expired - Fee Related DE69221634T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30234891 1991-10-21

Publications (2)

Publication Number Publication Date
DE69221634D1 DE69221634D1 (de) 1997-09-18
DE69221634T2 true DE69221634T2 (de) 1998-01-15

Family

ID=17907840

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69221634T Expired - Fee Related DE69221634T2 (de) 1991-10-21 1992-10-16 5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten
DE69201184T Expired - Fee Related DE69201184T2 (de) 1991-10-21 1992-10-16 5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69201184T Expired - Fee Related DE69201184T2 (de) 1991-10-21 1992-10-16 5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.

Country Status (12)

Country Link
US (2) US5378698A (de)
EP (2) EP0541263B1 (de)
JP (1) JP2818082B2 (de)
KR (1) KR100214902B1 (de)
CN (1) CN1034075C (de)
AT (2) ATE156821T1 (de)
CA (1) CA2080671A1 (de)
DE (2) DE69221634T2 (de)
DK (2) DK0615971T3 (de)
ES (2) ES2106439T3 (de)
GR (1) GR3024453T3 (de)
TW (1) TW221429B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU709280B2 (en) * 1996-02-23 1999-08-26 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivative
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
UA67760C2 (uk) * 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6897305B2 (en) * 1998-06-08 2005-05-24 Theravance, Inc. Calcium channel drugs and uses
US7101909B2 (en) * 1998-10-12 2006-09-05 Theravance, Inc. Calcium channel drugs and uses
CN1872846B (zh) * 1999-07-09 2010-06-16 宇部兴产株式会社 二苯并硫氮*衍生物的制备方法
EP2090663A3 (de) * 2000-06-28 2009-11-11 Takeda Pharmaceutical Company Limited Verfahren zur Herstellung von Herzmuskelzellen und Verfahren zum Suchen von Abhilfen für Herzkrankheiten
US7550459B2 (en) 2001-12-28 2009-06-23 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
ES2251624T3 (es) 2001-12-28 2006-05-01 Acadia Pharmaceuticals Inc. Analogos de la tetrahidroquinolina como los agonistas muscarinicos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
US4594342A (en) * 1984-04-10 1986-06-10 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivative
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4879289A (en) * 1988-05-24 1989-11-07 Marion Laboratories, Inc. Method of ameliorating epileptic seizures
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
FR2645744B1 (fr) * 1989-04-13 1994-01-21 Roussel Uclaf Derives de la benzothiazepine, leur procede de preparation et les intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines

Also Published As

Publication number Publication date
ATE116974T1 (de) 1995-01-15
US5462936A (en) 1995-10-31
DE69201184T2 (de) 1995-06-08
DE69221634D1 (de) 1997-09-18
CN1034075C (zh) 1997-02-19
EP0541263A1 (de) 1993-05-12
GR3024453T3 (en) 1997-11-28
ES2106439T3 (es) 1997-11-01
EP0615971B1 (de) 1997-08-13
EP0615971A1 (de) 1994-09-21
KR100214902B1 (ko) 1999-08-02
DK0541263T3 (da) 1995-04-18
CN1073168A (zh) 1993-06-16
KR930007943A (ko) 1993-05-20
EP0541263B1 (de) 1995-01-11
ATE156821T1 (de) 1997-08-15
US5378698A (en) 1995-01-03
CA2080671A1 (en) 1993-04-22
ES2069967T3 (es) 1995-05-16
JP2818082B2 (ja) 1998-10-30
TW221429B (de) 1994-03-01
DE69201184D1 (de) 1995-02-23
DK0615971T3 (da) 1997-10-06
JPH05201865A (ja) 1993-08-10

Similar Documents

Publication Publication Date Title
DK260588A (da) Heterocykliske ketoner
DK0976748T3 (da) Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
FR2662162B1 (fr) Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE69725113D1 (de) Azetidin- und Pyrrolidinderivate
ATE125808T1 (de) Indolederivate und ihre verwendung als serotonin- antagoniste.
EA200000023A1 (ru) Производные 2-(-4-арил или гетероарил-пиперазин-1-илметил) -1h-индола
DE69221634T2 (de) 5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten
DE69839753D1 (de) 2-(Arylphenyl)amino-imidazolin-Derivate
ATE73795T1 (de) Thioformamid-derivate.
DE3674546D1 (de) Amidderivate.
FR2629456B1 (fr) Derives des acides 7-(1-imidazolyl),1,4-dihydro-4-oxo-6,8-difluoro-1-cyclopropyl-3-quinoleincarboxylique, leur preparation et leur application en tant que medicaments

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee