ES2069967T3 - 5-piperazinilalquil-1,5-benzotiazepinonas utiles como antagonistas del calcio. - Google Patents

5-piperazinilalquil-1,5-benzotiazepinonas utiles como antagonistas del calcio.

Info

Publication number
ES2069967T3
ES2069967T3 ES92309474T ES92309474T ES2069967T3 ES 2069967 T3 ES2069967 T3 ES 2069967T3 ES 92309474 T ES92309474 T ES 92309474T ES 92309474 T ES92309474 T ES 92309474T ES 2069967 T3 ES2069967 T3 ES 2069967T3
Authority
ES
Spain
Prior art keywords
optionally substituted
useful
hydrogen
alkyl
benzotiazepinonas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92309474T
Other languages
English (en)
Inventor
Teruo Yamamori
Hiroshi Harada
Katsunori Sakai
Kazumi Iwaki
Kazuki Matsunaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2069967T3 publication Critical patent/ES2069967T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN COMPUESTO DE LA FORMULA: EN DONDE X ES =N-A-R1 O =C (R1) R2; A ES UN ENLACE SENCILLO, POLIMETILENO O -CO-; R1 Y R2 SON CADA UNO HIDROGENO, ALQUILO C1C6, CICLOALQUILO C3-C7, FENILO SUSTITUIDO O NO SUSTITUIDO, BENZHIDRILO OPCIONALMENTE SUSTITUIDO O UN GRUPO HETEROCICLICO DE 5 A 6 MIEMBROS OPCIONALMENTE SUSTITUIDO; Y ES HIDROGENO, HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C7, ALCOXI C1-C6, FENOXI OPCIONALMENTE SUSTITUIDO, BENCILOXI OPCIONALMENTE SUSTITUIDO O BENCILO OPCIONALMENTE SUSTITUIDO; Z ES HIDROGENO O ACILO; N ES UN ENTERO DE 2 A 6 Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. TAMBIEN SE PRESENTA UNA COMPOSICION FARMACEUTICA QUE CONTIENE EL COMPUESTO, QUE ES UTIL PARA EL TRATAMIENTO DE LA HIPERTENSION Y DE ENFERMEDADES CARDIACAS.
ES92309474T 1991-10-21 1992-10-16 5-piperazinilalquil-1,5-benzotiazepinonas utiles como antagonistas del calcio. Expired - Lifetime ES2069967T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30234891 1991-10-21

Publications (1)

Publication Number Publication Date
ES2069967T3 true ES2069967T3 (es) 1995-05-16

Family

ID=17907840

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94201425T Expired - Lifetime ES2106439T3 (es) 1991-10-21 1992-10-16 5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio.
ES92309474T Expired - Lifetime ES2069967T3 (es) 1991-10-21 1992-10-16 5-piperazinilalquil-1,5-benzotiazepinonas utiles como antagonistas del calcio.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES94201425T Expired - Lifetime ES2106439T3 (es) 1991-10-21 1992-10-16 5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio.

Country Status (12)

Country Link
US (2) US5378698A (es)
EP (2) EP0541263B1 (es)
JP (1) JP2818082B2 (es)
KR (1) KR100214902B1 (es)
CN (1) CN1034075C (es)
AT (2) ATE156821T1 (es)
CA (1) CA2080671A1 (es)
DE (2) DE69221634T2 (es)
DK (2) DK0615971T3 (es)
ES (2) ES2106439T3 (es)
GR (1) GR3024453T3 (es)
TW (1) TW221429B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU709280B2 (en) * 1996-02-23 1999-08-26 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivative
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
UA67760C2 (uk) * 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6897305B2 (en) * 1998-06-08 2005-05-24 Theravance, Inc. Calcium channel drugs and uses
US7101909B2 (en) * 1998-10-12 2006-09-05 Theravance, Inc. Calcium channel drugs and uses
CN1872846B (zh) * 1999-07-09 2010-06-16 宇部兴产株式会社 二苯并硫氮*衍生物的制备方法
EP2090663A3 (en) * 2000-06-28 2009-11-11 Takeda Pharmaceutical Company Limited Method of preparing heart muscle cells and method of searching for remedy for heart diseases
US7550459B2 (en) 2001-12-28 2009-06-23 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
ES2251624T3 (es) 2001-12-28 2006-05-01 Acadia Pharmaceuticals Inc. Analogos de la tetrahidroquinolina como los agonistas muscarinicos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
US4594342A (en) * 1984-04-10 1986-06-10 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivative
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4879289A (en) * 1988-05-24 1989-11-07 Marion Laboratories, Inc. Method of ameliorating epileptic seizures
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
FR2645744B1 (fr) * 1989-04-13 1994-01-21 Roussel Uclaf Derives de la benzothiazepine, leur procede de preparation et les intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines

Also Published As

Publication number Publication date
ATE116974T1 (de) 1995-01-15
US5462936A (en) 1995-10-31
DE69201184T2 (de) 1995-06-08
DE69221634D1 (de) 1997-09-18
CN1034075C (zh) 1997-02-19
EP0541263A1 (en) 1993-05-12
GR3024453T3 (en) 1997-11-28
ES2106439T3 (es) 1997-11-01
EP0615971B1 (en) 1997-08-13
EP0615971A1 (en) 1994-09-21
KR100214902B1 (ko) 1999-08-02
DK0541263T3 (da) 1995-04-18
CN1073168A (zh) 1993-06-16
KR930007943A (ko) 1993-05-20
EP0541263B1 (en) 1995-01-11
DE69221634T2 (de) 1998-01-15
ATE156821T1 (de) 1997-08-15
US5378698A (en) 1995-01-03
CA2080671A1 (en) 1993-04-22
JP2818082B2 (ja) 1998-10-30
TW221429B (es) 1994-03-01
DE69201184D1 (de) 1995-02-23
DK0615971T3 (da) 1997-10-06
JPH05201865A (ja) 1993-08-10

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