ATE125808T1 - Indolederivate und ihre verwendung als serotonin- antagoniste. - Google Patents

Indolederivate und ihre verwendung als serotonin- antagoniste.

Info

Publication number
ATE125808T1
ATE125808T1 AT91915720T AT91915720T ATE125808T1 AT E125808 T1 ATE125808 T1 AT E125808T1 AT 91915720 T AT91915720 T AT 91915720T AT 91915720 T AT91915720 T AT 91915720T AT E125808 T1 ATE125808 T1 AT E125808T1
Authority
AT
Austria
Prior art keywords
compound
effective
indole derivatives
lower alkyl
serotonin antagonists
Prior art date
Application number
AT91915720T
Other languages
English (en)
Inventor
Shoichi Chokai
Tomiyoshi Aoki
Yojiro Ukai
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of ATE125808T1 publication Critical patent/ATE125808T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AT91915720T 1990-08-31 1991-08-29 Indolederivate und ihre verwendung als serotonin- antagoniste. ATE125808T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23103090 1990-08-31
JP26584790 1990-10-02

Publications (1)

Publication Number Publication Date
ATE125808T1 true ATE125808T1 (de) 1995-08-15

Family

ID=26529663

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915720T ATE125808T1 (de) 1990-08-31 1991-08-29 Indolederivate und ihre verwendung als serotonin- antagoniste.

Country Status (7)

Country Link
US (1) US5342845A (de)
EP (1) EP0546181B1 (de)
AT (1) ATE125808T1 (de)
AU (1) AU8405891A (de)
CA (1) CA2090037A1 (de)
DE (2) DE69111816D1 (de)
WO (1) WO1992004347A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554781A (en) * 1994-03-30 1996-09-10 Reierson; Robert L. Monoalkyl phosphonic acid ester production process
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
SE0000540D0 (sv) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6500840B2 (en) 2000-08-21 2002-12-31 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
ATE355293T1 (de) * 2001-09-12 2006-03-15 Pharmacia & Upjohn Co Llc Substituierte 7-aza-(2.2.1)bicycloheptane für die behandlung von krankheiten
BR0213612A (pt) 2001-10-02 2004-08-24 Upjohn Co Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
EP1442041A1 (de) * 2001-11-08 2004-08-04 PHARMACIA & UPJOHN COMPANY Azabicyclisch substituierte heteroarylverbindungen zur behandlung von krankheiten
EP1442037A1 (de) 2001-11-09 2004-08-04 PHARMACIA & UPJOHN COMPANY Azabizyklo-phenyl-kondensierte-heterozyklische verbindungen und deren verwendung als alpha7 nachr liganden
WO2003070731A2 (en) * 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
BR0307735A (pt) * 2002-02-19 2005-01-25 Upjohn Co Carboxamidas heteroaromáticas com ligação-n em ponte biciclìcas fundidas para o tratamento de doença
WO2004013137A1 (en) * 2002-08-01 2004-02-12 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
WO2004039815A2 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
TW201707707A (zh) * 2015-03-26 2017-03-01 Ｌｇ生命科學股份有限公司 包含吲哚化合物之製劑及其製備方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175173A (en) * 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
EP0201165B1 (de) * 1985-03-14 1994-07-20 Beecham Group Plc Arzneimittel zur Behandlung von Emesis
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
GB8510752D0 (en) * 1985-04-27 1985-06-05 Beecham Group Plc Compounds
GB8525844D0 (en) * 1985-10-19 1985-11-20 Beecham Group Plc Compounds
JPS63277622A (ja) * 1986-12-17 1988-11-15 グラクソ、グループ、リミテッド 医薬
DE3751404T2 (de) * 1986-12-17 1995-12-21 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Bewusstseinsstörungen.
AU5650890A (en) * 1989-05-24 1990-12-18 Nippon Shinyaku Co. Ltd. Indole derivatives and medicine
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
DE4115215A1 (de) * 1991-05-10 1992-11-12 Merck Patent Gmbh Indolderivate

Also Published As

Publication number Publication date
EP0546181A4 (en) 1993-07-21
US5342845A (en) 1994-08-30
DE69111816D1 (de) 1995-09-07
WO1992004347A1 (fr) 1992-03-19
EP0546181A1 (de) 1993-06-16
CA2090037A1 (en) 1992-03-01
DE69111816T4 (de) 1996-08-01
EP0546181B1 (de) 1995-08-02
AU8405891A (en) 1992-03-30
DE69111816T2 (de) 1996-05-30

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties