DE69111816D1 - Indolederivate und ihre verwendung als serotonin-antagoniste. - Google Patents

Indolederivate und ihre verwendung als serotonin-antagoniste.

Info

Publication number
DE69111816D1
DE69111816D1 DE69111816A DE69111816A DE69111816D1 DE 69111816 D1 DE69111816 D1 DE 69111816D1 DE 69111816 A DE69111816 A DE 69111816A DE 69111816 A DE69111816 A DE 69111816A DE 69111816 D1 DE69111816 D1 DE 69111816D1
Authority
DE
Germany
Prior art keywords
compound
serotonin
effective
lower alkyl
indolederivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69111816A
Other languages
English (en)
Other versions
DE69111816T4 (de
DE69111816T2 (de
Inventor
Shoichi Chokai
Tomiyoshi Aoki
Yojiro Ukai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of DE69111816D1 publication Critical patent/DE69111816D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE69111816A 1990-08-31 1991-08-29 Indolederivate und ihre verwendung als serotonin-antagoniste. Expired - Fee Related DE69111816D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP23103090 1990-08-31
JP26584790 1990-10-02
PCT/JP1991/001148 WO1992004347A1 (fr) 1990-08-31 1991-08-29 Derive d'indole et medicament

Publications (1)

Publication Number Publication Date
DE69111816D1 true DE69111816D1 (de) 1995-09-07

Family

ID=26529663

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69111816T Expired - Lifetime DE69111816T4 (de) 1990-08-31 1991-08-29 Indolederivate und ihre verwendung als serotonin-antagoniste.
DE69111816A Expired - Fee Related DE69111816D1 (de) 1990-08-31 1991-08-29 Indolederivate und ihre verwendung als serotonin-antagoniste.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69111816T Expired - Lifetime DE69111816T4 (de) 1990-08-31 1991-08-29 Indolederivate und ihre verwendung als serotonin-antagoniste.

Country Status (7)

Country Link
US (1) US5342845A (de)
EP (1) EP0546181B1 (de)
AT (1) ATE125808T1 (de)
AU (1) AU8405891A (de)
CA (1) CA2090037A1 (de)
DE (2) DE69111816T4 (de)
WO (1) WO1992004347A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554781A (en) * 1994-03-30 1996-09-10 Reierson; Robert L. Monoalkyl phosphonic acid ester production process
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
SE0000540D0 (sv) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
EP1425286B1 (de) * 2001-09-12 2007-02-28 Pharmacia & Upjohn Company LLC Substituierte 7-aza-[2.2.1]bicycloheptane für die behandlung von krankheiten
IL160884A0 (en) 2001-10-02 2004-08-31 Upjohn Co Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
MXPA04004464A (es) * 2001-11-08 2004-08-11 Upjohn Co Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
BR0214016A (pt) 2001-11-09 2004-10-13 Upjohn Co Compostos azabicìclico-fenil-fundido heterocìclicos e seu uso como ligandos alfa 7 nachr
MXPA04008152A (es) * 2002-02-19 2005-09-08 Upjohn Co Compuestos azabiciclicos para el tratamiento de enfermedades.
JP2005523288A (ja) * 2002-02-19 2005-08-04 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 疾病治療用の縮合した二環式−ｎ−架橋−複素環式芳香族カルボキサミド
JP2005537297A (ja) * 2002-08-01 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー アルファ−７ｎａｃｈｒ活性を有する１ｈ−ピラゾールおよび１ｈ−ピロール−アザビシクロ化合物
BR0315056A (pt) * 2002-11-01 2005-08-16 Pharmacia & Upjohn Co Llc Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central
TW201707707A (zh) * 2015-03-26 2017-03-01 Ｌｇ生命科學股份有限公司 包含吲哚化合物之製劑及其製備方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175173A (en) * 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
EP0405617A3 (en) * 1985-03-14 1992-11-25 Beecham Group P.L.C. Medicaments for the treatment of anxiety
GB8510752D0 (en) * 1985-04-27 1985-06-05 Beecham Group Plc Compounds
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
GB8525844D0 (en) * 1985-10-19 1985-11-20 Beecham Group Plc Compounds
DE3788057T2 (de) * 1986-12-17 1994-03-03 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen.
DE3752062T2 (de) * 1986-12-17 1997-09-11 Glaxo Group Ltd Verwendung von heterozyklischen Derivaten zur Herstellung von Arzneimitteln
AU5650890A (en) * 1989-05-24 1990-12-18 Nippon Shinyaku Co. Ltd. Indole derivatives and medicine
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
DE4115215A1 (de) * 1991-05-10 1992-11-12 Merck Patent Gmbh Indolderivate

Also Published As

Publication number Publication date
EP0546181B1 (de) 1995-08-02
US5342845A (en) 1994-08-30
WO1992004347A1 (fr) 1992-03-19
CA2090037A1 (en) 1992-03-01
EP0546181A1 (de) 1993-06-16
DE69111816T4 (de) 1996-08-01
AU8405891A (en) 1992-03-30
ATE125808T1 (de) 1995-08-15
DE69111816T2 (de) 1996-05-30
EP0546181A4 (en) 1993-07-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee