ATE355293T1 - Substituierte 7-aza-(2.2.1)bicycloheptane für die behandlung von krankheiten - Google Patents
Substituierte 7-aza-(2.2.1)bicycloheptane für die behandlung von krankheitenInfo
- Publication number
- ATE355293T1 ATE355293T1 AT02757132T AT02757132T ATE355293T1 AT E355293 T1 ATE355293 T1 AT E355293T1 AT 02757132 T AT02757132 T AT 02757132T AT 02757132 T AT02757132 T AT 02757132T AT E355293 T1 ATE355293 T1 AT E355293T1
- Authority
- AT
- Austria
- Prior art keywords
- bicycloheptanes
- aza
- diseases
- substituted
- treatment
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32234601P | 2001-09-12 | 2001-09-12 | |
| US32210001P | 2001-09-12 | 2001-09-12 | |
| US32233301P | 2001-09-12 | 2001-09-12 | |
| US39953002P | 2002-07-30 | 2002-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE355293T1 true ATE355293T1 (de) | 2006-03-15 |
Family
ID=27502238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02757132T ATE355293T1 (de) | 2001-09-12 | 2002-09-04 | Substituierte 7-aza-(2.2.1)bicycloheptane für die behandlung von krankheiten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20030105089A1 (de) |
| EP (1) | EP1425286B1 (de) |
| JP (1) | JP2005527472A (de) |
| AR (1) | AR036779A1 (de) |
| AT (1) | ATE355293T1 (de) |
| BR (1) | BR0212477A (de) |
| CA (1) | CA2460075A1 (de) |
| DE (1) | DE60218493D1 (de) |
| MX (1) | MXPA04002377A (de) |
| WO (1) | WO2003022856A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| EP1476448A2 (de) * | 2002-02-19 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Azabicyclische verbindungen zur behandlung von erkrankungen |
| US7001900B2 (en) | 2002-02-20 | 2006-02-21 | Pfizer Inc. | Azabicyclic compounds for the treatment of disease |
| ES2405594T3 (es) | 2002-09-25 | 2013-05-31 | Memory Pharmaceuticals Corporation | Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos |
| CA2503786A1 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases |
| AU2003269413A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| DK1949901T3 (da) | 2002-12-06 | 2014-05-19 | The Feinstein Inst Medical Res | Fremgangsmåde til bestemmelse af en cholinerg agonist selektiv for en alfa-7-nikotinsk receptor |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| MXPA05008108A (es) * | 2003-02-21 | 2005-09-21 | Pharmacia & Upjohn Co Llc | Exo-(2r)(+))-2-amino-7-azabiciclo[2.2.1]heptan-7-carboxilato de terc-butilo, compuestos intermedios y procedimiento para prepararlos y aislarlos. |
| WO2004091482A2 (en) * | 2003-04-07 | 2004-10-28 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| GB0310867D0 (en) * | 2003-05-12 | 2003-06-18 | Novartis Ag | Organic compounds |
| WO2005063767A2 (en) | 2003-12-22 | 2005-07-14 | Memory Pharmaceuticals Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof |
| US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
| RU2417225C2 (ru) | 2004-03-25 | 2011-04-27 | Мемори Фармасьютиклз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение |
| CA2567977A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| JP2007538011A (ja) | 2004-05-07 | 2007-12-27 | メモリー・ファーマシューティカルズ・コーポレイション | 1h−インダゾール、ベンゾチアゾール、1,2−ベンゾイソキサゾール、1,2−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用 |
| JP2008525464A (ja) | 2004-12-22 | 2008-07-17 | メモリー・ファーマシューティカルズ・コーポレイション | α−7ニコチン性受容体リガンド並びにその製造及び使用 |
| NZ575512A (en) | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| CN101305010A (zh) * | 2005-09-01 | 2008-11-12 | 阿雷生物药品公司 | Raf抑制剂化合物及其用法 |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| WO2007068620A1 (en) * | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-c]pyridine derivatives |
| CA2645137A1 (en) | 2006-03-07 | 2007-09-13 | James F. Blake | Heterobicyclic pyrazole compounds and methods of use |
| WO2008083124A1 (en) | 2006-12-28 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| MX2010005298A (es) | 2007-11-16 | 2010-06-30 | Rigel Pharmaceuticals Inc | Compuestos de carboxamida, sulfonamida y amina para trastornos metabolicos. |
| WO2009076631A1 (en) | 2007-12-12 | 2009-06-18 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| EA021119B1 (ru) | 2008-04-23 | 2015-04-30 | Райджел Фармасьютикалз, Инк. | Карбоксамидные соединения для лечения метаболических расстройств |
| WO2009158375A1 (en) * | 2008-06-25 | 2009-12-30 | Abbott Laboratories | Aza-cylic indole- 2 -carboxamides and methods of use thereof |
| SI2540297T1 (sl) | 2008-11-19 | 2015-08-31 | Forum Pharmaceuticals Inc. | Zdravljenje kognitivne motnje z (R)-7-Kloro-N-(kinuklidin-3-il)benzo(b)tiofen-2-karboksamid in farmacevtsko nje sprejemljivih soli |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| US8431595B2 (en) | 2009-08-20 | 2013-04-30 | The University Of Tennessee Research Foundation | Furanopyridine cannabinoid compounds and related methods of use |
| EP2523562B1 (de) | 2010-01-11 | 2019-01-02 | Astraea Therapeutics, LLC | Nikotin-acetylcholinrezeptor-antagonisten |
| NZ603625A (en) | 2010-05-17 | 2014-10-31 | Envivo Pharmaceuticals Inc | A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
| WO2012082746A2 (en) * | 2010-12-13 | 2012-06-21 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EP3666272A1 (de) | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Verwendung von encenicline bei der behandlung von kognitiver behinderung, alzheimer-krankheit, speicherdefizit |
| KR101684955B1 (ko) | 2012-07-23 | 2016-12-12 | 주식회사유한양행 | 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물 |
| US10154992B2 (en) | 2016-07-12 | 2018-12-18 | The Regents Of The University Of California | Compounds and methods for treating HIV infection |
| US11572374B2 (en) | 2018-08-14 | 2023-02-07 | Amgen Inc. | N-cyano-7-azanorbornane derivatives and uses thereof |
| AU2021384833A1 (en) * | 2020-11-18 | 2023-06-15 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
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|---|---|---|---|---|
| ZA832549B (en) * | 1982-04-14 | 1988-09-28 | Beecham Group Plc | Pharmaceutically active compounds |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
| JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
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| GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
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| EP0289170B1 (de) * | 1987-04-25 | 1993-06-23 | Beecham Group Plc | Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
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| US4950759A (en) * | 1988-07-07 | 1990-08-21 | Duphar International Research B.V. | Substituted 1,7-annelated 1H-indazoles |
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-
2002
- 2002-09-04 BR BR0212477-7A patent/BR0212477A/pt not_active IP Right Cessation
- 2002-09-04 DE DE60218493T patent/DE60218493D1/de not_active Expired - Lifetime
- 2002-09-04 EP EP02757132A patent/EP1425286B1/de not_active Expired - Lifetime
- 2002-09-04 AT AT02757132T patent/ATE355293T1/de not_active IP Right Cessation
- 2002-09-04 WO PCT/US2002/025959 patent/WO2003022856A1/en not_active Ceased
- 2002-09-04 MX MXPA04002377A patent/MXPA04002377A/es active IP Right Grant
- 2002-09-04 US US10/234,575 patent/US20030105089A1/en not_active Abandoned
- 2002-09-04 JP JP2003526930A patent/JP2005527472A/ja not_active Abandoned
- 2002-09-04 CA CA002460075A patent/CA2460075A1/en not_active Abandoned
- 2002-09-11 AR ARP020103445A patent/AR036779A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2460075A1 (en) | 2003-03-20 |
| EP1425286B1 (de) | 2007-02-28 |
| BR0212477A (pt) | 2004-08-24 |
| JP2005527472A (ja) | 2005-09-15 |
| AR036779A1 (es) | 2004-10-06 |
| DE60218493D1 (de) | 2007-04-12 |
| MXPA04002377A (es) | 2004-11-22 |
| US20030105089A1 (en) | 2003-06-05 |
| EP1425286A1 (de) | 2004-06-09 |
| WO2003022856A1 (en) | 2003-03-20 |
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